Article
Clinical Neurology
Yoshio Tsuboi, Masatoshi Nakamura, Hidenori Maruyama, Yuji Matsumoto
Summary: This study found that zonisamide can improve wearing off in patients with PD without exacerbating dyskinesia, with the 50 mg dose potentially benefiting the improvement of dyskinesia. Further research is needed to determine the clinical relevance and benefits of zonisamide on dyskinesia more clearly.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Olivier Rascol, Rossella Medori, Corine Baayen, Pedro Such, Didier Meulien
Summary: There was no evidence that foliglurax has efficacy in improving levodopa-induced motor complications in patients with Parkinson's disease.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Parisa Farzanehfar, Holly Woodrow, Malcolm Horne
Summary: The study found that a high proportion of patients with Parkinson's disease experience motor and non-motor function wearing off, with severity correlated to factors such as disease duration, baseline MDS-UPDRS (motor component), Percent Time in Bradykinesia, Levodopa Equivalent Daily Dose, frequency of Levodopa doses, and age of onset. Patients with more severe wearing off experienced worse motor and non-motor symptoms, resulting in lower quality of life. Quality of life significantly improved in patients with Parkinson's disease when wearing off was treated.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Michelle S. Troche, James A. Curtis, Jordanna S. Sevitz, Avery E. Dakin, Sarah E. Perry, James C. Borders, Alessandro A. Grande, Yuhan Mou, Nora Vanegas-Arroyave, Karen W. Hegland
Summary: Disorders of airway protection are common in Parkinson's disease (PD) and can lead to aspiration pneumonia and death. This study compared expiratory muscle strength training (EMST) and sensorimotor training for airway protection (smTAP) to improve cough-related outcomes in PD patients. The results showed that smTAP was more effective than EMST in improving cough function.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Roseanne D. Dobkin, Sarah L. Mann, Daniel Weintraub, Kailyn M. Rodriguez, Rachael B. Miller, Lauren St. Hill, Arlene King, Michael A. Gara, Alejandro Interian
Summary: This study compared the efficacy of individual Parkinson's-informed, video-to-home cognitive-behavioral therapy with clinic-based treatment for depression in Parkinson's disease. The results showed that video-to-home cognitive-behavioral therapy outperformed clinic-based treatment across multiple depression measures, with effects maintained through 6 months follow-up.
MOVEMENT DISORDERS
(2021)
Review
Clinical Neurology
Meimei Zhang, Huimin Chen, Genliang Liu, Xuemei Wang, Zhan Wang, Tao Feng, Yumei Zhang
Summary: The quantity and location of lacunae are significantly associated with the wearing-off phenomenon in Parkinson's disease (PD) patients, and may be independent contributors to the phenomenon. Promoting neurovascular health may prevent the progression of the wearing-off phenomenon in PD patients.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Chin-Hsien Lin, Chin-Hao Chang, Chun-Hwei Tai, Mei-Fang Cheng, Yi-Chieh Chen, Ying-Ting Chao, Tse-Le Huang, Ruoh-Fang Yen, Ruey-Meei Wu
Summary: Evidence suggests that lovastatin may slow the progression of motor symptoms in patients with early-stage PD, especially in the striatal region. The treatment was generally well tolerated, indicating the potential benefits of lovastatin in PD management.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Kishoree Sangarapillai, Benjamin M. Norman, Quincy J. Almeida
Summary: This study found that sensory exercise was more effective than boxing in improving motor symptoms for Parkinson's disease patients. Furthermore, the benefits of sensory exercise did not wear off after the intervention was completed.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Clinical Neurology
Lubos Brabenec, Patricia Klobusiakova, Patrik Simko, Milena Kostalova, Jiri Mekyska, Irena Rektorova
Summary: This study evaluated the long-term effects of repetitive transcranial magnetic stimulation on hypokinetic dysarthria in Parkinson's disease, showing that real stimulation led to improvements in speech articulation compared to sham stimulation. The neural mechanisms of these improvements involve activation increases in specific brain regions and enhanced intrinsic connectivity.
Article
Clinical Neurology
Anja J. H. Moonen, Anne E. P. Mulders, Luc Defebvre, Annelien Duits, Berengere Flinois, Sebastian Kohler, Mark L. Kuijf, Anne-Claire Leterme, Dominique Servant, Marjolein de Vugt, Kathy Dujardin, Albert F. G. Leentjens
Summary: This study assessed the effectiveness of cognitive behavioral therapy (CBT) in treating anxiety in patients with Parkinson's disease. Results showed that CBT is an effective treatment for reducing situational and social anxiety, as well as avoidance behavior.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Junhuai Zhang, Jiayu Li, Fang Chen, Xingzhi Liu, Chun Jiang, Xinghua Hu, Lin Ma, Zhongye Xu
Summary: Both STN and GPi-DBS were equally effective in improving motor dysfunction in patients with APD. However, STN-DBS showed superiority in reducing medication usage, while GPi-DBS may lead to less dyskinesia and improved activities of daily living. Further studies comparing adverse events and quality of life between these two targets are needed.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Clinical Neurology
Takayasu Mishima, Shih-Wei Chiu, Hidemoto Saiki, Takuhiro Yamaguchi, Yasushi Shimo, Tetsuya Maeda, Hirohisa Watanabe, Kenichi Kashihara, Masahiro Nomoto, Nobutaka Hattori, Yoshio Tsuboi
Summary: This study investigated the risk factors and impact of dyskinesia in Parkinson's disease patients exhibiting wearing-off. The results showed that female sex and the use of dopamine agonists, catechol-O-methyltransferase inhibitors, or zonisamide were independent risk factors for dyskinesia onset within 1 year. Dyskinesia onset led to deterioration in nonmotor symptoms and quality of life.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Eric Freire-Alvarez, Egon Kurca, Lydia Lopez Manzanares, Eero Pekkonen, Cleanthe Spanaki, Paola Vanni, Yang Liu, Olga Sanchez-Solino, Luigi M. Barbato
Summary: The study showed that LCIG significantly reduced dyskinesia compared to oral optimized medical treatment, and also demonstrated significant improvements in quality of life and activities of daily living in patients with advanced Parkinson's disease.
MOVEMENT DISORDERS
(2021)
Article
Medicine, General & Internal
Joel Pollet, Riccardo Buraschi, Giorgia Ranica, Simone Pancera, Denise Anastasi, Rossella Fazio, Serena Monteleone, Eleonora Lena, Valeria Floridi, Franco Zucchini, Maurizio Vincenzo Falso
Summary: The study assessed the effect of a newly designed custom-made insole called PRO-STEP on subjects with Parkinson's Disease. The results showed that PRO-STEP did not significantly improve the walking time and gait parameters in PD patients. However, PD patients were satisfied with the PRO-STEP insoles. Future studies should consider modifying the stimulation method to improve its effectiveness in PD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Heng Zhai, Wenliang Fan, Yan Xiao, Zhipeng Zhu, Ying Ding, Chentao He, Wei Zhang, Yan Xu, Yuhu Zhang
Summary: Our study aimed to explore the functional connectivity alterations between cortical nodes of resting-state networks in Parkinson's disease (PD) patients with wearing-off (WO) at different levels. Resting-state functional magnetic resonance imaging was performed on 36 PD patients without wearing-off (PD-nWO), 30 PD patients with wearing-off (PD-WO), and 35 healthy controls (HCs) to extract functional networks. The results showed significantly reduced connectivity strength in the dorsal attention network and limbic network in the PD-WO group compared with the HC group, and altered intra- and internetwork connections in PD patients with WO.
NEUROLOGICAL SCIENCES
(2023)
Article
Immunology
Yasunobu Hoshino, Daisuke Noto, Shuhei Sano, Yuji Tomizawa, Kazumasa Yokoyama, Nobutaka Hattori, Sachiko Miyake
Summary: This study demonstrates that B cells in patients with NMOSD are abnormally skewed towards antibody-secreting cells at the transcriptome level during the early differentiation phase, and IL-2 might participate in this pathogenic process. CD25(+) naive B cells are identified as a novel candidate precursor of antibody-secreting cells in autoimmune diseases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Cloe Domenighetti, Pierre-Emmanuel Sugier, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Oceane Mohamed, Berta Portugal, Patrick May, Dheeraj R. Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew B. Singleton, Dena G. Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E. Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugenie Mutez, Kathrin Brockmann, Angela B. Deutschlaender, Georges M. Hadjigeorgiou, Efthimos Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Stefano Duga, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Yusuke Kawamura, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bart P. C. van de Warrenburg, Bastiaan R. Bloem, Jan Aasly, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J. Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Monica Diez-Fairen, Karin Wirdefeldt, Nancy L. Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Clara Hellberg, Carl E. Clarke, Karen E. Morrison, Manuela Tan, Dimitri Krainc, Lena F. Burbulla, Matt J. Farrer, Rejko Kruger, Thomas Gasser, Manu Sharma, Alexis Elbaz
Summary: There is an association between genetically predicted dairy intake and Parkinson's disease, particularly in men. This causal relationship is not explained by reverse causation or confounding factors, as confirmed by Mendelian randomization analysis.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Christina Andica, Akifumi Hagiwara, Kazumasa Yokoyama, Shimpei Kato, Wataru Uchida, Yuma Nishimura, Shohei Fujita, Koji Kamagata, Masaaki Hori, Yuji Tomizawa, Nobutaka Hattori, Shigeki Aoki
Summary: This study combined NODDI and SyMRI to evaluate GM microstructural alterations in RRMS and NMOSD patients, revealing reduced NDI and MVF and increased ODI and ISOVF in RRMS patients, mainly in limbic and paralimbic regions, while NMOSD patients showed reduced NDI in different cortical areas. RRMS and NMOSD exhibited distinct GM pathologies, with cautious interpretation of the results due to study limitations.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Sachiko Noda, Shigeto Sato, Takahiro Fukuda, Shinichi Ueno, Norihiro Tada, Nobutaka Hattori
Summary: The study investigated the role of FBXO7 gene mutations in Parkinson's disease and found that these mutations lead to a decrease in dopaminergic neurons and the formation of protein aggregates. They also discovered mitochondrial fragmentation in neuronal cells, suggesting that dysfunction in proteolytic and mitochondrial degradation systems plays a crucial role in the development of Parkinson's disease.
Article
Clinical Neurology
Atsushi Takeda, Yoshio Tsuboi, Masahiro Nomoto, Hideki Mochizuki, Nobutaka Hattori
Summary: This study provides expert perspectives on the use of Safinamide for different clinical scenarios in Japan, offering recommendations for its use in clinical practice.
PARKINSONS DISEASE
(2022)
Letter
Clinical Neurology
Noriko Nishikawa, Taku Hatano, Daiki Kamiyama, Haruna Haginiwa-Hasegawa, Genko Oyama, Nobutaka Hattori
JOURNAL OF MOVEMENT DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Tatou Iseki, Yuzuru Imai, Nobutaka Hattori
Summary: Leucine rich-repeat kinase 2 (LRRK2) is the most well-known genetic cause of familial Parkinson's disease (PD). Its functions and relationship to the pathogenesis of PD are not fully understood. Recent studies have suggested that LRRK2 plays a role in glial cell dysfunction and neurodegeneration, particularly in lysosomal dynamics and inflammation. This review discusses the proposed functions of LRRK2 in glial cells and its involvement in the pathomechanisms of PD.
Article
Medicine, General & Internal
Nobutaka Hattori, Yoshiko Okada, Yayoi Kawata, Yoshihiko Furusawa, Takumi Imai, Hisako Yoshida, Mihoko Ota, Masaki Arai, Ayumi Shintani, Jovelle Fernandez
Summary: This study aimed to investigate the impact of the COVID-19 pandemic on patients with Parkinson's disease and their caregivers in Japan. The results showed that over 40% of patients reduced their frequency of going out, approximately 7-30% experienced worsened symptoms, and caregivers reported increased burden. The findings suggest the importance of providing support to patients and caregivers during infectious disease epidemics to alleviate their burden.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Biochemistry & Molecular Biology
Yuri Yamashita, Satoshi Nakada, Kyoko Nakamura, Hidetoshi Sakurai, Kinji Ohno, Tomohide Goto, Yo Mabuchi, Chihiro Akazawa, Nobutaka Hattori, Eri Arikawa-Hirasawa
Summary: Schwartz-Jampel syndrome (SJS) is a rare genetic disorder characterized by myotonia. In this study, a cellular model of SJS was created using patient-derived induced pluripotent stem cells, which showed hyper-responsiveness to acetylcholine. These findings confirmed the use of cellular models in studying SJS and evaluating myotonia in clinical cases.
Editorial Material
Clinical Neurology
Nobutaka Hattori
NEURODEGENERATIVE DISEASE MANAGEMENT
(2023)
Article
Clinical Neurology
Christina Andica, Koji Kamagata, Wataru Uchida, Yuya Saito, Kaito Takabayashi, Akifumi Hagiwara, Haruka Takeshige-Amano, Taku Hatano, Nobutaka Hattori, Shigeki Aoki
Summary: This study compared the white matter differences between nonmedicated patients with early-stage GBA-PD and iPD using a novel technique, fixel-based analysis. The results showed that patients with GBA-PD had lower white matter density, while patients with iPD had larger white matter fiber bundles. These findings may be related to neurodegenerative diseases, α-synuclein accumulation, and cognitive and motor impairments.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Amica C. Mueller-Nedebock, Marieke C. J. Dekker, Matthew J. Farrer, Nobutaka Hattori, Shen-Yang Lim, George D. Mellick, Irena Rektorova, Mohamed Salama, Artur F. S. Schuh, A. Jon Stoessl, Carolyn M. Sue, Ai Huey Tan, Rene L. Vidal, Christine Klein, Soraya Bardien
Summary: The biological basis of Parkinson's disease, a neurodegenerative movement disorder, is still unclear despite being discovered over 200 years ago. This article summarizes the viewpoints of PD experts on the different theories regarding its pathobiology.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Wataru Sako, Yuki Kogo, Michinori Koebis, Yoshiaki Kita, Hajime Yamakage, Takayuki Ishida, Nobutaka Hattori
Summary: This study compared the efficacy, tolerability, and safety of different classes of anti-PD drugs in patients with fluctuating PD who were receiving levodopa. The results showed that ropinirole, pramipexole, and safinamide are well-balanced anti-PD drugs that have both good efficacy and tolerability.
NPJ PARKINSONS DISEASE
(2023)
Article
Biology
Davide Cossu, Yuji Tomizawa, Kazumasa Yokoyama, Tamami Sakanishi, Eiichi Momotani, Leonardo A. Sechi, Nobutaka Hattori
Summary: The study analyzed the levels of different IgG subclasses in the blood of Japanese and Italian individuals with relapsing remitting multiple sclerosis (MS) in response to MAP-derived peptides. The study also examined the effects of MAP peptides on MOG-induced experimental autoimmune encephalomyelitis (EAE) in mice. The results suggest a potential link between MAP and the development or exacerbation of MS, particularly in individuals with elevated serum IgG4 levels.
Article
Clinical Neurology
Anri Sakurai, Taiji Tsunemi, Yuta Ishiguro, Ayami Okuzumi, Taku Hatano, Nobutaka Hattori
Summary: The study found that approximately 29.1% of iNPH patients had comorbid PD/PDD, while about 10.1% had comorbid DLB. Comorbid PD/PDD or DLB showed significant differences in facial expansion and upper-limb parkinsonism. DaTscan and RT-QuIC can help differentiate these diseases and affect their clinical features.
JOURNAL OF NEUROLOGY
(2022)