Article
Clinical Neurology
Gabriel Bsteh, Harald Hegen, Patrick Altmann, Michael Auer, Klaus Berek, Franziska Di Pauli, Lukas Haider, Barbara Kornek, Nik Krajnc, Fritz Leutmezer, Stefan Macher, Paulus Rommer, Lisa-Maria Walchhofer, Karin Zebenholzer, Gudrun Zulehner, Florian Deisenhammer, Berthold Pemp, Thomas Berger
Summary: This study investigated the predictive role of baseline peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell and inner plexiform layer (GCIPL) thickness in disability accumulation in early relapsing multiple sclerosis (RMS). Retinal layer thickness, particularly GCIPL thickness, was found to be a useful predictor of future disability accumulation in RMS, adding to established markers.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Christina Noll, Michael Hiltensperger, Lilian Aly, Rebecca Wicklein, Ali Maisam Afzali, Christian Mardin, Christiane Gasperi, Achim Berthele, Bernhard Hemmer, Thomas Korn, Benjamin Knier
Summary: This study found that rarefication of the retinal vasculature during RRMS is associated with higher frequencies of activated B cells and higher levels of pro-inflammatory cytokines in the cerebrospinal fluid. Furthermore, vessel loss in the retina is linked to future disability worsening.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Philipp Matten, Julius Scherer, Thomas Schlegl, Jonas Nienhaus, Heiko Stino, Michael Niederleithner, Ursula M. Schmidt-Erfurth, Rainer A. Leitgeb, Wolfgang Drexler, Andreas Pollreisz, Tilman Schmoll
Summary: Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults with diabetes mellitus, and optical coherence tomography angiography (OCTA) has shown potential as a tool for early diagnosis. We propose a multiple instance learning-based network, MIL-ResNet, capable of detecting biomarkers in OCTA images with high accuracy without pixel-level annotations. Our method outperforms previous state-of-the-art networks and is robust against adversarial attacks, making it a powerful diagnostic decision support tool for clinical ophthalmic screening.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Soheil Mohammadi, Mahdi Gouravani, Mohammad Amin Salehi, J. Fernando Arevalo, Steven L. Galetta, Hamid Harandi, Elliot M. Frohman, Teresa C. Frohman, Shiv Saidha, Neda Sattarnezhad, Friedemann Paul
Summary: Recent literature on MS has shown an increasing use of OCT-A to detect changes in the retina and optic nerve. This review analyzes OCT-A studies in MS patients and its potential as a surrogate for CNS tissue changes.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Medicine, General & Internal
Thanh-Tin P. Nguyen, Shuibin Ni, Guangru Liang, Shanjida Khan, Xiang Wei, Alison Skalet, Susan Ostmo, Michael F. Chiang, Yali Jia, David Huang, Yifan Jian, J. Peter Campbell
Summary: OCT has changed the standard of care for macular diseases in adults, but commercially available systems have a narrow FOV limiting their application to peripheral pathologies; OCT-based evaluation can improve diagnosis of all types of retinal detachment.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Katharina Klumbies, Rebekka Rust, Jan Doerr, Frank Konietschke, Friedemann Paul, Judith Bellmann-Strobl, Alexander U. Brandt, Hanna G. Zimmermann
Summary: In this study, treatment with EGCG did not show a neuroprotective effect on retinal thickness analysis, consistent with the results of the main clinical trial. However, the study may have been underpowered to detect an effect.
FRONTIERS IN NEUROLOGY
(2021)
Review
Health Care Sciences & Services
Ioannis-Nikolaos Chalkias, Christos Bakirtzis, Demetrios Pirounides, Marina Kleopatra Boziki, Nikolaos Grigoriadis
Summary: This review provides insights into the recent findings of OCT and OCT-A in MS. Current literature suggests that RNFL and GC-IPL are significantly reduced in people with MS and are inversely correlated with disease duration. OCT-A findings include reduced vessel density in the macula and peripapillary area, as well as enlargement of the foveal avascular zone in optic neuritis cases.
Article
Immunology
Eva Feodora Romahn, Tun Wiltgen, Matthias Bussas, Lilian Aly, Rebecca Wicklein, Christina Noll, Achim Berthele, Vera Dehmelt, Christian Mardin, Claus Zimmer, Thomas Korn, Bernhard Hemmer, Jan S. Kirschke, Mark Muehlau, Benjamin Knier
Summary: Optical coherence tomography angiography can assess retinal vessel structures in patients with multiple sclerosis. The thinning and loss of retinal vessels are associated with brain atrophy and disability in multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Josephine Wauschkuhn, Gilberto Solorza Buenrostro, Lilian Aly, Susanna Asseyer, Rebecca Wicklein, Julia Maria Hartberger, Klemens Ruprecht, Mark Muehlau, Tanja Schmitz-Huebsch, Claudia Chien, Achim Berthele, Alexander U. U. Brandt, Thomas Korn, Friedemann Paul, Bernhard Hemmer, Hanna G. G. Zimmermann, Benjamin Knier
Summary: Thinning of retinal combined ganglion cell and inner plexiform layer (GCIP) as measured by OCT is common in patients with multiple sclerosis. This study aimed to investigate whether a single retinal OCT analysis allows prediction of future disease activity after a first demyelinating event. The results showed that GCIP thickness measurement provides information for early risk stratification and progression of multiple sclerosis after the initial manifestation.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Omid Mirmosayyeb, Robert Zivadinov, Bianca Weinstock-Guttman, Ralph H. B. Benedict, Dejan Jakimovski
Summary: There is an association between retinal nerve fiber layer thickness and cognitive performance in patients with multiple sclerosis, particularly in terms of cognitive processing speed, verbal learning and memory, visual learning and memory, and verbal fluency.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Olwen C. Murphy, Elias S. Sotirchos, Grigorios Kalaitzidis, Elena Vasileiou, Henrik Ehrhardt, Jeffrey Lambe, Ohemaa Kwakyi, James Nguyen, Alexandra Zambriczki Lee, Julia Button, Blake E. Dewey, Scott D. Newsome, Ellen M. Mowry, Kathryn C. Fitzgerald, Jerry L. Prince, Peter A. Calabresi, Shiv Saidha
Summary: This study investigated longitudinal changes in brain volumetric measures and retinal layer thicknesses following acute optic neuritis in people with multiple sclerosis. The results suggest that there is anterograde trans-synaptic degeneration after acute optic neuritis, which may have clinical relevance to visual outcomes.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Eleni S. Vasileiou, Angeliki G. Filippatou, Daniela Pimentel Maldonado, Grigorios Kalaitzidis, Henrik Ehrhardt, Jeffrey Lambe, Shiv Saidha, Elias S. Sotirchos, Ellen M. Mowry, Peter A. Calabresi, Kathryn C. Fitzgerald
Summary: This study found that individuals with lower socioeconomic status experienced faster retinal neurodegeneration in multiple sclerosis, as well as a negative correlation between socioeconomic status and low contrast letter acuity loss. Furthermore, individuals with low socioeconomic status had faster rates of therapy escalation, suggesting that the association with retinal atrophy may not be explained by differential treatment management.
Review
Biochemistry & Molecular Biology
Vlad Constantin Donica, Anisia Iuliana Alexa, Irina Andreea Pavel, Ciprian Danielescu, Manuela Andreea Ciapa, Alexandra Lori Donica, Camelia Margareta Bogdanici
Summary: This paper discusses the increasing prevalence of multiple sclerosis among young people in developing countries and introduces the main biomarkers identified through Optical Coherence Tomography Angiography. It investigates the potential role of this technology in studying changes to the central nervous system.
Article
Clinical Neurology
Xuejiao Wang, Xuqian Wang, Yuyu Chou, Jin Ma, Yong Zhong
Summary: This study investigated the retinal microvascular changes in eyes with multiple sclerosis (MS) using optical coherence tomography angiography (OCTA). The findings revealed significant impairment in retinal microvasculature in MS patients regardless of optic neuritis history. The detection of retinal vessel density attenuation by OCTA may serve as a reliable early marker of MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Genetics & Heredity
Felix Rommel, David Prangel, Michelle Prasuhn, Salvatore Grisanti, Mahdy Ranjbar
Summary: The study aimed to investigate the correlation between retinal and choroidal microperfusion in systemic sclerosis (SSc) patients using optical coherence tomography angiography (OCTA). Results showed impaired perfusion in both tissues, supporting the hypothesis of widespread vascular injury in SSc patients. In early stages, either the retinal or the choroidal perfusion may be involved, while later on, vascular impairment affects both tissues alike.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Ophthalmology
Dipesh E. Patel, Phillippa M. Cumberland, Bronwen C. Walters, Joseph Abbott, John Brookes, Beth Edmunds, Peng Tee Khaw, Ian Christopher Lloyd, Maria Papadopoulos, Velota Sung, Mario Cortina-Borja, Jugnoo S. Rahi
Summary: This expert consensus study found commonality of views among experts in implementing perimetry and interpreting test quality in the management of children with glaucoma. However, there remains a lack of agreement about defining progressive visual field loss and utilizing perimetry over an individual's lifetime, highlighting the need for further research.
Article
Ophthalmology
Mark J. Simcoe, Ameet Shah, Baojian Fan, Helene Choquet, Nicole Weisschuh, Naushin H. Waseem, Chen Jiang, Ronald B. Melles, Robert Ritch, Omar A. Mahroo, Bernd Wissinger, Eric Jorgenson, Janey L. Wiggs, David F. Garway-Heath, Pirro G. Hysi, Christopher J. Hammond
Summary: A genome-wide association meta-analysis identified genetic variants associated with pigment dispersion syndrome and pigmentary glaucoma. Two novel loci were found, and the study also demonstrated that myopia has a causal effect on pigment dispersion syndrome.
Article
Engineering, Biomedical
Christopher Kai Shun Leung, Alexander Ka Ngai Lam, Robert Neal Weinreb, David F. Garway-Heath, Marco Yu, Philip Yawen Guo, Vivian Sheung Man Chiu, Kelvin Ho Nam Wan, Mandy Wong, Ken Zhongheng Wu, Carol Yim Lui Cheung, Chen Lin, Carmen Kar Mun Chan, Noel Ching Yan Chan, Ka Wai Kam, Gilda Wing Ki Lai
Summary: Optical texture analysis of the retinal nerve fibre layer, through an algorithm integrating thickness and reflectance measurements from standard wide-field optical coherence tomography, outperforms conventional tomographic analysis in the detection of optic neuropathies.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Ophthalmology
Georgios Lazaridis, Giovanni Montesano, Saman Sadeghi Afgeh, Jibran Mohamed-Noriega, Sebastien Ourselin, Marco Lorenzi, David F. Garway-Heath
Summary: A deep learning method was developed to predict visual function using SD-OCT-derived measurements and images. The method showed excellent accuracy and outperformed other approaches in predicting VF sensitivity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Kian M. Madjedi, Kelsey Stuart, Sharon Y. L. Chua, Robert N. Luben, Alasdair Warwick, Louis R. Pasquale, Jae H. Kang, Janey L. Wiggs, Marleen A. H. Lentjes, Hugues Aschard, Naveed Sattar, Paul J. Foster, Anthony P. Khawaja
Summary: The study found that serum levels of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol are positively associated with intraocular pressure, while triglyceride levels may be negatively associated.
Article
Medicine, General & Internal
Iris Kleerekooper, Sharon Chua, Paul J. Foster, S. Anand Trip, Gordon T. Plant, Axel Petzold, Praveen Patel
Summary: The study found that current smoking, moderate alcohol intake, and obesity were significantly associated with MS case status. High alcohol intake was associated with thinner mGCIPL in individuals with MS. Smoking was associated with greater mGCIPL thickness in control individuals but not in those with MS.
Article
Ophthalmology
Ashleigh Kernohan, Tara Homer, Hosein Shabaninejad, Anthony J. King, Jemma Hudson, Gordon Fernie, Augusto Azuara-Blanco, Jennifer Burr, John M. Sparrow, David Garway-Heath, Keith Barton, John Norrie, Graeme Maclennan, Luke Vale
Summary: This study compares medical and surgical management strategies for advanced glaucoma and suggests that medication may be more cost-effective over a 2-year time horizon.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Alasdair N. Warwick, Katie Curran, Barbra Hamill, Kelsey Stuart, Anthony P. Khawaja, Paul J. Foster, Andrew J. Lotery, Michael Quinn, Savita Madhusudhan, Konstantinos Balaskas, Tunde Peto
Summary: This study describes the grading methods and baseline characteristics for UK Biobank participants who underwent retinal imaging, and characterizes individuals with retinal features suggestive of age-related macular degeneration, glaucoma, and retinopathy. The results provide important insights into both ocular and systemic health.
Article
Ophthalmology
Gus Gazzard, Evgenia Konstantakopoulou, David Garway-Heath, Mariam Adeleke, Victoria Vickerstaff, Gareth Ambler, Rachael Hunter, Catey Bunce, Neil Nathwani, Keith Barton, The LiGHT Trial Study Grp
Summary: After 6 years of treatment, selective laser trabeculoplasty (SLT) has been shown to be a more effective and cost-effective primary treatment for open-angle glaucoma (OAG) and ocular hypertension (OHT) compared to intraocular pressure (IOP)-lowering eye drops. The SLT group had better glaucoma symptom scores and 69.8% of eyes in this group achieved or maintained the target IOP without the need for medical or surgical treatment.
Article
Ophthalmology
Anthony J. King, Jemma Hudson, Augusto Azuara-Blanco, James F. Kirwan, Saurabh Goyal, Kin Sheng Lim, Graeme Maclennan
Summary: This study evaluates the impact of socioeconomic status on treatment outcomes in patients with advanced glaucoma and reports the correlation between socioeconomic status and baseline characteristics. The study found that socioeconomic status is correlated with visual function, quality of life, ethnicity, age, and number of optician visits.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Juliane Matlach, Padraig Mulholland, Marketa Cilkova, Reena Chopra, Nilpa Shah, Tony Redmond, Steven C. Dakin, David F. Garway-Heath, Roger S. Anderson
Summary: This study investigated the age-related changes of outer nuclear layer (ONL) thickness and cone density in healthy participants using a modified narrow scan-angle Heidelberg Retina Angiograph (HRA2). The results showed that both cone density and ONL thickness decreased with age. However, there was no strong correlation between cone density and ONL thickness, suggesting that factors other than cone density contribute to ONL thickness measurements.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Correction
Ophthalmology
Alasdair Warwick, Katie Curran, Barbra Hamill, Kelsey Stuart, Anthony P. Khawaja, Paul J. Foster, Andrew J. Lotery, Michael Quinn, Savita Madhusudhan, Konstantinos Balaskas, Tunde Peto
Article
Ophthalmology
Kelsey V. Stuart, Robert N. Luben, Alasdair N. Warwick, Kian M. Madjedi, Praveen J. Patel, Mahantesh I. Biradar, Zihan Sun, Mark A. Chia, Louis R. Pasquale, Janey L. Wiggs, Jae H. Kang, Jihye Kim, Hugues Aschard, Jessica H. Tran, Marleen A. H. Lentjes, Paul J. Foster, Anthony P. Khawaja
Summary: The purpose of this study was to examine the associations between alcohol consumption and glaucoma and related traits, assess whether genetic predisposition to glaucoma modified these associations, and perform MR experiments to investigate causal effects. The findings showed consistent and adverse associations between alcohol intake and glaucoma and related traits, even at levels below the current guidelines in the UK and the US.
OPHTHALMOLOGY GLAUCOMA
(2023)
Review
Cell Biology
Dimitrios Stavropoulos, Manjot K. K. Grewal, Bledi Petriti, Kai-Yin Chau, Christopher J. J. Hammond, David F. F. Garway-Heath, Gerassimos Lascaratos
Summary: This review aims to provide a better understanding of the emerging role of mitophagy in glaucomatous neurodegeneration, which is the primary cause of irreversible blindness worldwide. Increasing evidence from genetic and other experimental studies suggests that mitophagy-related genes are implicated in the pathogenesis of glaucoma in various populations. The association between polymorphisms in these genes and increased risk of glaucoma is presented.
Article
Ophthalmology
Joel S. Schuman, Maria De los Angeles Ramos Cadena, Rebecca McGee, Lama A. Al-Aswad, Felipe A. Medeiros
Summary: The application of artificial intelligence (AI) in clinical testing for glaucoma has the potential to improve the detection of the disease. This premise was discussed at a recent ophthalmic imaging meeting, which highlighted the importance of using AI technology to increase access to glaucoma diagnosis worldwide, especially in remote areas.
OPHTHALMOLOGY GLAUCOMA
(2022)