Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Neurosciences
Marina Botello-Marabotto, M. Carmen Martinez-Bisbal, Miguel Calero, Andrea Bernardos, Ana B. Pastor, Miguel Medina, Ramon Martinez-Manez
Summary: This study employed 1H NMR spectroscopy to conduct a metabolomic study in serum samples from patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls (HC). The aim was to search for potential metabolite biomarkers. The results highlight the potential of 1H NMR metabolomics to support the diagnosis of dementia in a less invasive way, and provide a starting point for the study of potential biomarkers to identify MCI or HC subjects at risk of developing AD in the future.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Allan I. Levey, Deqiang Qiu, Liping Zhao, William T. Hu, Duc M. Duong, Lenora Higginbotham, Eric B. Dammer, Nicholas T. Seyfried, Thomas S. Wingo, Chadwick M. Hales, Malu Gamez Tansey, David S. Goldstein, Anees Abrol, Vince D. Calhoun, Felicia C. Goldstein, Ihab Hajjar, Anne M. Fagan, Doug Galasko, Steven D. Edland, John Hanfelt, James J. Lah, David Weinshenker
Summary: The study demonstrated that atomoxetine, a clinically approved noradrenaline reuptake inhibitor, improved multiple Alzheimer's disease biomarkers in individuals with mild cognitive impairment. Treatment with atomoxetine significantly reduced CSF levels of Tau and pTau, normalized CSF protein biomarker panels linked to synaptic function, brain metabolism, and glial immunity, and increased brain activity and metabolism in key temporal lobe circuits.
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Yorito Hattori, Satoshi Saito, Yuriko Nakaoku, Soshiro Ogata, Masashi Hattori, Mio Nakatsuji, Kunihiro Nishimura, Masafumi Ihara
Summary: This retrospective study investigated the association between TAX intake and cognitive changes. The results showed that TAX intake was significantly associated with changes in visuospatial/executive function, verbal fluency, and total score of MoCA, but not with ADAS-Cog. These findings provide a basis for TAX as a novel strategy for maintaining brain health.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
David L. Sultzer, Aaron C. Lim, Hailey L. Gordon, Brandon C. Yarns, Rebecca J. Melrose
Summary: This study found lower nicotinic cholinergic receptor binding in specific limbic and subcortical regions in MCI and AD dementia patients compared to CU older adults, which is related to cognitive deficits.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Computer Science, Artificial Intelligence
Sunghong Park, Chang Hyung Hong, Dong-gi Lee, Kanghee Park, Hyunjung Shin
Summary: With the rapid aging of the population, Alzheimer's disease (AD) is becoming a serious problem, and early detection of the disease is crucial. By learning brain atrophy patterns, machine learning algorithms can predict the conversion from mild cognitive impairment (MCI) to AD. However, it is challenging to distinguish between the conversion group and the non-conversion group due to small differences and large within-group variability in brain images. To address this issue, a method called prospective classification, which projects brain images into the future for classification, is proposed.
Article
Biochemistry & Molecular Biology
Bruna De Felice, Cinzia Coppola, Simona Bonavita, Elisabetta Signoriello, Concetta Montanino, Federica Farinella, Carmela Matrone
Summary: Mild cognitive impairment (MCI) is a transitional stage before dementia with a high risk of progression to Alzheimer's disease. Non-coding RNAs, including long non-coding RNAs (lncRNAs), play a crucial role in gene expression regulation and can improve understanding of the genetic factors and pathophysiology of MCI. This study identified the expression patterns and relevant lncRNA-associated miRNA regulatory axes in the blood of MCI patients, proposing RNA targets involved in the pathogenesis of MCI.
Review
Food Science & Technology
Guangsu Zhu, Jianxin Zhao, Hao Zhang, Wei Chen, Gang Wang
Summary: Analysis of randomized controlled trials suggests that dietary supplementation with probiotics may improve cognitive function, particularly in individuals with mild cognitive impairment.
Article
Clinical Neurology
Egle Audronyte, Vaiva Sutnikiene, Gyte Pakulaite-Kazliene, Gintaras Kaubrys
Summary: This study investigated olfactory memory and its relationship with verbal memory and other clinical features in patients with early-stage Alzheimer's disease (AD). The results showed that olfactory memory was significantly impaired in patients with AD compared to individuals with mild cognitive impairment due to AD and cognitively normal older participants. Furthermore, the duration of AD symptoms was a strong predictor of olfactory recognition memory scores.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Mingrui Liu, Baohu Liu, Zelin Ye, Dongyu Wu
Summary: This study used a bibliometric approach to analyze the application of electroencephalogram (EEG) in mild cognitive impairment (MCI) from 2005 to 2022. The research emphasis has shifted from examining local brain lesions with EEG to neural network mechanisms. The use of big data and intelligent analysis methods in EEG research is becoming more important, and linking MCI to other neurological disorders and evaluating new targets for diagnosis and treatment has become a new research trend.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O'Brien, Abhay Moghekar, Michael W. Lutz
Summary: This study measured 3072 proteins in the CSF samples of AD-biomarker positive MCI patients and controls, and found an upregulation of neuroinflammatory pathways, particularly chemotactic and granulocyte recruitment pathways, in the CSF of early AD patients.
Article
Neurosciences
Jasmin E. Guevara, Natalie E. Kurniadi, Kevin Duff
Summary: This study quantifies cognitive change in patients with mild cognitive impairment (MCI) using standardized regression-based (SRB) z-scores. The findings show a significant decline in cognitive function over time, especially in learning and memory. Patients who progressed to dementia (MCI-Decline) showed more decline compared to those who remained stable (MCI-Stable). The study highlights the value of SRB in quantifying cognitive decline and identifying individuals at higher risk for MCI progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
