Article
Multidisciplinary Sciences
Jung-Jae Kim, Hyeondong Yang, Yong Bae Kim, Je Hoon Oh, Kwang-Chun Cho
Summary: This study investigated the relationship between hemodynamic parameters and aneurysm formation through analyzing the distances between high wall shear stress and high strain locations. Results showed that high strain is an important factor related to cerebral aneurysm formation, with the proximity of high strain locations to the aneurysm site being smaller than high wall shear stress locations.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Jose Barahona, Alvaro Valencia, Maria Torres
Summary: This study investigated the effects of different shapes of pulsatile pressure on hemodynamics in models of cerebral aneurysms. It found that an isolated systolic hypertension condition may have a greater impact on arterial wall remodeling and rupture risk compared to a normal or hypertensive condition.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Biomedical
Seyedeh Fatemeh Salimi Ashkezari, Fernando Mut, Bong Jae Chung, Anne M. Robertson, Juhana Frosen, Juan R. Cebral
Summary: This study analyzed changes in the hemodynamic environment of cerebral aneurysms from initial development to later stages of enlargement. The flow characteristics differed between aneurysms with fixed necks and growing necks, with fixed neck aneurysms potentially evolving towards stable environments faster than aneurysms with growing necks. The findings suggest that the evolution of aneurysm flow characteristics is influenced by neck growth patterns.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Jian Zhang, Pui Man Rosalind Lai, Anil Can, Srinivasan Mukundan, Victor M. Castro, Dmitriy Dligach, Sean Finan, Vivian S. Gainer, Nancy A. Shadick, Guergana Savova, Shawn N. Murphy, Tianxi Cai, Scott T. Weiss, Rose Du
Summary: This study investigated morphological features and clinical factors associated with ruptured ACoA aneurysms. Morphologic features such as the presence of a daughter dome, smaller neck diameter, larger aspect ratio, larger flow angle, and smaller ipsilateral A2-ACoA angle were associated with rupture. Tobacco use was predominantly associated with intrinsic morphological factors while younger age was associated with extrinsic morphological features related to rupture.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Radoslav Raychev, Stanimir Sirakov, Alexander Sirakov, Hamidreza Saber, Fernando Vinuela, Reza Jahan, May Nour, Viktor Szeder, Geoffrey Colby, Gary Duckwiler, Satoshi Tateshima
Summary: This study aimed to investigate the hemodynamic changes in intracranial aneurysms and parent vessels after flow diversion (FD) treatment, as well as the occurrence of silent emboli. The results showed that the early and sustained visibility of the eclipse sign was the most reliable predictor of permanent aneurysm occlusion at 12 months. Additionally, none of the patients experienced silent emboli.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Soichiro Fujimura, Kazutoshi Tanaka, Hiroyuki Takao, Takuma Okudaira, Hirokazu Koseki, Akiko Hasebe, Takashi Suzuki, Yuya Uchiyama, Toshihiro Ishibashi, Katharina Otani, Kostadin Karagiozov, Koji Fukudome, Motoharu Hayakawa, Makoto Yamamoto, Yuichi Murayama
Summary: This study investigates the relationship between aneurysm initiation and hemodynamic factors using angiographic images of patients with cerebral aneurysms taken before and after an aneurysm formation. The findings suggest that aneurysm initiation is more likely to occur in areas with high tensile forces acting on the vessel wall and high total pressure loss.
JOURNAL OF NEUROSURGERY
(2022)
Article
Health Care Sciences & Services
Ui Yun Lee, Hyo Sung Kwak
Summary: This study evaluated morphological and hemodynamic factors in assessing the risk of rupture in cerebral aneurysms with a size of >= 7 mm, finding significant correlations between factors like high aspect ratio and low TVR with aneurysm rupture risk.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Pasquale Marco Abbate, A. T. M. Hasibul Hasan, Alice Venier, Vincent Vauclin, Silvia Pizzuto, Alessandro Sgreccia, Federico Di Maria, Oguzhan Coskun, Katsuhiro Mizutani, Georges Rodesch, Arturo Consoli
Summary: Aneurysms are a focal or segmental disease of the arterial wall. Their formation and growth are influenced by genetic/environmental factors, altered structural and pathologic events, as well as interaction with the surrounding environment and luminal flow dynamics.
APPLIED SCIENCES-BASEL
(2022)
Article
Clinical Neurology
Qingyuan Liu, Yisen Zhang, Junhua Yang, Yi Yang, Maogui Li, Shanwen Chen, Pengjun Jiang, Nuochuan Wang, Yanan Zhang, Jia Liu, Jun Wu, Shuo Wang
Summary: The study focused on the important pathological characteristic of aneurysm wall remodeling (AWR) in intracranial aneurysms (IAs) and identified key factors related to AWR, inflammation levels, and atherosclerosis in IA tissues. Biomechanical stress and inflammation in aneurysm wall were found to be correlated, providing potential pathological evidence for IA development.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mingzhu Fu, Fei Peng, Hao Niu, Xiaoxin He, Shuo Chen, Miaoqi Zhang, Jiaxiang Xia, Yishi Wang, Boya Xu, Aihua Liu, Rui Li
Summary: This study investigated the association between inflow angle and morphology, hemodynamic, and inflammation of intracranial side-wall and bifurcation aneurysms. The results showed a significant correlation between inflow angle and aneurysm size, wall shear stress, and aneurysmal wall enhancement in side-wall aneurysms, while no significant associations were found in bifurcation aneurysms.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Multidisciplinary Sciences
Sricharan S. Veeturi, Hamidreza Rajabzadeh-Oghaz, Nandor K. Pinter, Muhammad Waqas, David M. Hasan, Kenneth Snyder, Adnan H. Siddiqui, Vincent M. Tutino
Summary: Vessel wall enhancement (VWE) in unruptured intracranial aneurysms has been found to be associated with aneurysm risk, with strong correlations between CRstalk and size, and moderate correlation with rupture resemblance score (RRS). Additionally, CRstalk showed weak negative correlation with normalized wall shear stress (WSS) and weak positive correlation with size ratio (SR). Local voxel-based analysis revealed a weak negative correlation between WSS and contrast-enhanced MRI signal intensity, suggesting potential non-localized effects of low-normalized WSS on enhancement-associated pathobiology.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Clinical Neurology
Yajie Wang, Jie Sun, Rui Li, Peng Liu, Xian Liu, Jiansong Ji, Chunmiao Chen, Yu Chen, Haikun Qi, Yunduo Li, Longhui Zhang, Luqiong Jia, Fei Peng, Mingzhu Fu, Yishi Wang, Min Xu, Chunli Kong, Shuiwei Xia, Xiaole Wang, Le He, Qiang Zhang, Zhensen Chen, Aihua Liu, Youxiang Li, Ming Lv, Huijun Chen
Summary: In this study, the spatial relationship between hemodynamic forces and aneurysm wall permeability in unruptured saccular intracranial aneurysms was investigated. It was found that aneurysm wall permeability varied between aneurysms and within the same aneurysm, showing spatial heterogeneity. Higher permeability was associated with lower wall shear stress, indicating a potential link between aneurysm wall remodeling and hemodynamic factors.
JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Ashrita Raghuram, Alberto Varon, Jorge A. Roa, Daizo Ishii, Yongjun Lu, Madhavan L. Raghavan, Chaorong Wu, Vincent A. Magnotta, David M. Hasan, Timothy R. Koscik, Edgar A. Samaniego
Summary: Aneurysm wall enhancement (AWE) can be a potential biomarker of unstable intracranial aneurysms, and using a semi-automated method for quantifying AWE in 3D imaging was found to be more reliable. General aneurysm wall enhancement (GAWE) was accurate in detecting known morphological determinants of aneurysm instability, while specific aneurysm wall enhancement (SAWE) and focal aneurysm wall enhancement (FAWE) were used to characterize enhancement patterns within the aneurysm wall. Three-dimensional AWE mapping proved to be a powerful objective tool in characterizing different biological processes of the aneurysm wall.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Xinyu Liang, Fei Peng, Yunchu Yao, Yuting Yang, Aihua Liu, Duanduan Chen
Summary: This study investigated the pathophysiological mechanisms of intracranial fusiform aneurysms (IFAs) based on the characteristics of aneurysm wall enhancement (AWE), hemodynamics, and morphology. The results showed significant associations between AWE and aneurysm size as well as hemodynamic parameters. Further research is needed to understand the underlying pathological mechanisms of different types of fusiform aneurysms.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Lorenzo Pescatori, Giovanni Grasso, Maria Pia Tropeano, Fabio Torregrossa, Giorgio Santoro, Pasquale Ciappetta
Summary: A retrospective study of 170 cases of complex intracranial aneurysms treated at the institution between 1990 and 2020 showed that endovascular treatment should be the treatment of choice. Surgical clipping and revascularization are alternative methods, and the correct identification of the therapeutic process ensures good clinical outcomes.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Naoki Kaneko, Mahsa Ghovvati, Yutaro Komuro, Lea Guo, Kasra Khatibi, Lucido L. Ponce Mejia, Hamidreza Saber, Nasim Annabi, Satoshi Tateshima
Summary: The study found that clot stiffness had an impact on the success of endovascular thrombectomy using different devices. The Neurostar catheter with hydro-separator showed better recanalization rates compared to a commercially available aspiration catheter and stent retriever in experimental models.
INTERVENTIONAL NEURORADIOLOGY
(2022)
Article
Neuroimaging
Kasra Khatibi, Hamidreza Saber, Ramin Javahery, Naoki Kaneko, Lucido Luciano Ponce Mejia, Satoshi Tateshima
Summary: A teenager with a history of acute myeloid leukemia presented with symptoms such as headache, nausea and blurry vision. MRI findings revealed a myeloid sarcoma within the right sigmoid sinus. A biopsy confirmed the recurrence of leukemia, guiding targeted oncologic treatment.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Neuroimaging
Ivan Lylyk, Carlos Bleise, Pedro N. Lylyk, Nicolas Perez, Javier Lundquist, Esteban Scrivano, Anibal A. Francone, Martin Charles, Tamara Zompa, Pedro Lylyk
Summary: The study aims to investigate the correlation between AMD and compromised blood flow in the eye, as well as to demonstrate the potential of OA angioplasty as a treatment for late-stage AMD. Results showed the feasibility and safety of OA angioplasty, with perceived benefits in patients with profound vision loss. Further clinical trials are needed to confirm these findings.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Neuroimaging
Pedro Lylyk, Ivan Lylyk, Carlos Bleise, Esteban Scrivano, Pedro Nicolas Lylyk, Brandon Beneduce, Carl B. Heilman, Adel M. Malek
Summary: The novel minimally invasive endovascular cerebrospinal fluid shunt described in the text successfully treated intractable hydrocephalus in an octogenarian, rapidly reducing intracranial pressure and resolving ventriculomegaly. This first successful development of percutaneous transluminal venous access to the central nervous system provides a new pathway for non-invasive treatment of hydrocephalus and potential intervention against neurological disorders.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Editorial Material
Neuroimaging
Charles Beaman, Hamidreza Saber, Satoshi Tateshima
Summary: Robotic catheter angiography is an emerging technology that can improve procedural precision and reduce occupational hazards. This study presents initial experiences with the CorPath GRX Robotic System, including technical considerations and operational challenges.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Reprint
Neuroimaging
Satoshi Tateshima, Hamidreza Saber, Geoffrey P. Colby, Dieter Enzmann, Gary Duckwiler
Summary: Robotic-assisted technology has shown promise in coronary and peripheral vascular interventions and has been demonstrated to be effective in neuro-interventions. This report demonstrates the feasibility of using the robotic-assisted platform for spinal angiography.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Naoki Kaneko, Ariel Takayanagi, Hamidreza Saber, Lea Guo, Satoshi Tateshima
Summary: The study evaluated the efficacy of the Stabilizer for navigation in challenging vascular models and found that it significantly improved success rates in handling giant aneurysms, severe tortuosity, and M1 stenosis models compared to conventional wires.
INTERVENTIONAL NEURORADIOLOGY
(2022)
Article
Medicine, General & Internal
Marta Aguilar Perez, Hans Henkes, Wiebke Kurre, Carlos Bleise, Pedro Nicolas Lylyk, Javier Lundquist, Francis Turjman, Hanan Alhazmi, Christian Loehr, Stephan Felber, Hannes Deutschmann, Stephan Lowens, Luigi Delehaye, Markus Moehlenbruch, Joerg Hattingen, Pedro Lylyk
Summary: Coil embolization is a well-established treatment for intracranial aneurysms, but wide-neck bifurcation aneurysms (WNBAs) remain challenging. The pCONUS, a stent-like implant, has shown to be a safe and effective option for the treatment of WNBAs, with acceptable rates of aneurysm occlusion and low risks of adverse neurologic events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Neuroimaging
Ivan Lylyk, Carlos Bleise, Pedro N. Lylyk, Nicolas Perez, Javier Lundquist, Esteban Scrivano, Anibal A. Francone, Martin Charles, Tamara Zompa, Pedro Lylyk
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Neuroimaging
Hamidreza Saber, Charles Beaman, Satoshi Tateshima
Summary: In this study, we demonstrate the feasibility of robot-assisted neurointervention technology in a patient with acute epistaxis complicated by severe COVID-19.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Biochemical Research Methods
Alfonso Santiago, Constantine Butakoff, Beatriz Eguzkitza, Richard A. Gray, Karen May-Newman, Pras Pathmanathan, Vi Vu, Mariano Vazquez
Summary: This study presents a model of the LV-LVAD system and a VVUQ plan based on ASME standards to ensure credible predictions. The simulation was validated using the SDSU cardiac simulator, and the numerical model was based on Alya. The VVUQ plan included risk analysis, verification stage, sensitivity analysis, and uncertainty quantification. The results showed correctness of the solution procedure and identified the most impactful inputs for the analysed quantities of interest. The simulations were computationally expensive but demonstrated the feasibility of stringent VVUQ according to ASME standards.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hadrien Calmet, Damien Dosimont, David Oks, Guillaume Houzeaux, Brenda Vara Almirall, Kiao Inthavong
Summary: Targeted nasal drug delivery can be improved by adjusting spray parameters. This study investigated the effects of different values of six spray parameters on particle deposition. Sensitivity analysis showed that particle size significantly affected deposition in the olfactory and posterior regions, while spray device insertion angle had a significant impact on deposition in the anterior and middle regions. Machine learning models based on 384 cases provided accurate predictions despite the small sample dataset.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Clinical Neurology
Brian Tsui, Iris E. Chen, May Nour, Shingo Kihira, Elham Tavakkol, Jennifer Polson, Haoyue Zhang, Joe Qiao, Mersedeh Bahr-Hosseini, Corey Arnold, Satoshi Tateshima, Noriko Salamon, J. Pablo Villablanca, Geoffrey P. Colby, Reza Jahan, Gary Duckwiler, Jeffrey L. Saver, David S. Liebeskind, Kambiz Nael
Summary: This study compares the diagnostic performance and predictive impact of perfusion collateral index and hypoperfusion intensity ratio in collateral assessment. The results show that the perfusion collateral index outperforms the hypoperfusion intensity ratio in evaluating collateral status, infarct growth, and functional outcomes.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Mechanics
J. C. Cajas, I. Rodriguez, E. Salcedo, O. Lehmkuhl, G. Houzeaux, C. Trevino
Summary: The effect of aspect ratio on vortex induced vibrations (VIV) of a pivoted circular cylinder with different length-to-diameter ratios was studied. The study found that the aspect ratio influenced the oscillation amplitudes, synchronization region, and wake structures. At lower reduced velocities, steady symmetrical flow was obtained for cylinders with small aspect ratios, but became unstable at higher velocities.
Article
Computer Science, Interdisciplinary Applications
David Oks, Guillaume Houzeaux, Mariano Vazquez, Michael Neidlin, Cristobal Samaniego
Summary: This study evaluates the effect of TAVR commissural alignment on coronary perfusion and device performance using a computational fluid-structure interaction model.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)