Complement activation contributes to perioperative neurocognitive disorders in mice

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

(2018) Jean-François Ghersi-Egea et al.   ACTA NEUROPATHOLOGICA

Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice

(2018) J. Hu et al.   BRITISH JOURNAL OF ANAESTHESIA

The role of the complement system in traumatic brain injury: a review

(2018) Adnan Hammad et al.   Journal of Neuroinflammation

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

(2018) Chao Xiong et al.   Jove-Journal of Visualized Experiments

Sterile Inflammation of Brain, due to Activation of Innate Immunity, as a Culprit in Psychiatric Disorders

(2018) Mariusz Z. Ratajczak et al.   Frontiers in Psychiatry

Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

(2017) Javier Morán et al.   EXPERIMENTAL NEUROLOGY

Monitoring C3aR Expression Using a Floxed tdTomato-C3aR Reporter Knock-in Mouse

(2017) Katharina M. Quell et al.   JOURNAL OF IMMUNOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

(2017) Rink-Jan Lohman et al.   Nature Communications

NETosis in Alzheimer’s Disease

(2017) Enrica Caterina Pietronigro et al.   Frontiers in Immunology

Tissue plasminogen activator mediates deleterious complement cascade activation in stroke

(2017) Xue-Jun Zhao et al.   PLoS One

Cell-penetrating interactomic inhibition of nuclear factor-kappa B in a mouse model of postoperative cognitive dysfunction

(2017) So Yeong Cheon et al.   Scientific Reports

The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients

(2016) Sharon K. Inouye et al.   Alzheimers & Dementia

Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia

(2016) Anna Stokowska et al.   BRAIN

Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery

(2016) Jan Hirsch et al.   Journal of Neuroinflammation

Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain

(2016) Fengjiao Wu et al.   Journal of Neuroinflammation

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system

(2016) Sandro Dá Mesquita et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Preexisting Cognitive Impairment Is Associated with Postoperative Cognitive Dysfunction after Hip Joint Replacement Surgery

(2015) Brendan Silbert et al.   ANESTHESIOLOGY

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Development and functions of the choroid plexus–cerebrospinal fluid system

(2015) Melody P. Lun et al.   NATURE REVIEWS NEUROSCIENCE

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats

(2014) Hongying Tan et al.   Journal of Neuroinflammation

Peripheral Surgical Wounding and Age-Dependent Neuroinflammation in Mice

(2014) Zhipeng Xu et al.   PLoS One

Depletion of Bone Marrow–derived Macrophages Perturbs the Innate Immune Response to Surgery and Reduces Postoperative Memory Dysfunction

(2013) Vincent Degos et al.   ANESTHESIOLOGY

High-mobility Group Box 1 Protein Initiates Postoperative Cognitive Decline by Engaging Bone Marrow–derived Macrophages

(2013) Susana Vacas et al.   ANESTHESIOLOGY

The Therapeutic Potential of Atorvastatin in a Mouse Model of Postoperative Cognitive Decline

(2013) Marcela P. Vizcaychipi et al.   ANNALS OF SURGERY

Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline

(2013) Niccolò Terrando et al.   FASEB JOURNAL

Intranasal Administration of CNS Therapeutics to Awake Mice

(2013) Leah R. Hanson et al.   Jove-Journal of Visualized Experiments

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Resolving postoperative neuroinflammation and cognitive decline

(2011) Niccolò Terrando et al.   ANNALS OF NEUROLOGY

Role of interleukin-1β in postoperative cognitive dysfunction

(2010) Mario Cibelli et al.   ANNALS OF NEUROLOGY

Tumor necrosis factor-  triggers a cytokine cascade yielding postoperative cognitive decline

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