CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis

Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1

(2013) Nicole A de Weerd et al.   NATURE IMMUNOLOGY

The impact of interferon-alpha treatment on clinical and immunovirological aspects of HTLV-1-associated myelopathy in northeast of Iran

(2012) Houshang Rafatpanah et al.   JOURNAL OF NEUROIMMUNOLOGY

Ascorbic Acid Has Superior Ex Vivo Antiproliferative, Cell Death-Inducing and Immunomodulatory Effects over IFN-α in HTLV-1-Associated Myelopathy

(2012) Britta Moens et al.   PLoS Neglected Tropical Diseases

Systems Biology Approaches Reveal a Specific Interferon-Inducible Signature in HTLV-1 Associated Myelopathy

(2012) Sonja Tattermusch et al.   PLoS Pathogens

Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis

(2011) Henner Morbach et al.   ARTHRITIS AND RHEUMATISM

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility

(2011) N. Couturier et al.   BRAIN

Effect of TNF-α production inhibitors on the production of pro-inflammatory cytokines by peripheral blood mononuclear cells from HTLV-1-infected individuals

(2011) T. Luna et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis

(2011) Elisabeth Calderón-Gómez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Beta-interferon for multiple sclerosis

(2011) Richard A. Rudick et al.   EXPERIMENTAL CELL RESEARCH

B Cells as a Therapeutic Target for IFN-β in Relapsing–Remitting Multiple Sclerosis

(2011) Vinod S. Ramgolam et al.   JOURNAL OF IMMUNOLOGY

Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP

(2011) Maria Fernanda Rios Grassi et al.   JOURNAL OF MEDICAL VIROLOGY

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

(2011) Stephanie Knippenberg et al.   JOURNAL OF NEUROIMMUNOLOGY

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

(2011) Ludwig Kappos et al.   LANCET

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Making Sense out of Antisense Transcription in Human T-Cell Lymphotropic Viruses (HTLVs)

(2011) Benoit Barbeau et al.   Viruses-Basel

B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance

(2010) J.-J. Park et al.   BLOOD

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

(2010) Nicolas Manel et al.   NATURE

Dissecting Interferon-Induced Transcriptional Programs in Human Peripheral Blood Cells

(2010) Simon J. Waddell et al.   PLoS One

Human T cell leukemia virus type 1 infection drives spontaneous proliferation of natural killer cells

(2010) Philip J. Norris et al.   Virulence

Types I and II interferons upregulate the costimulatory CD80 molecule in monocytes via interferon regulatory factor-1

(2009) B. Bauvois et al.   BIOCHEMICAL PHARMACOLOGY

Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells

(2009) R. Colisson et al.   BLOOD

Abnormally High Levels of Virus-Infected IFN-γ+CCR4+CD4+CD25+ T Cells in a Retrovirus-Associated Neuroinflammatory Disorder

(2009) Yoshihisa Yamano et al.   PLoS One

Differential Role for CD80 and CD86 in the Regulation of the Innate Immune Response in Murine Polymicrobial Sepsis

(2009) Anna Nolan et al.   PLoS One

In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

(2009) Mineki Saito et al.   Retrovirology

The Elevated Interferon Gamma Production is an Important Immunological Marker in HAM/TSP Pathogenesis

(2009) P. A. Montanheiro et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF- B

(2008) T. Zhao et al.   BLOOD

Interferon-β-1b

(2008) Kate McKeage   CNS DRUGS

Interferon-β treatment for relapsing multiple sclerosis

(2008) Bianca Weinstock-Guttman et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

(2008) Beichu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells

(2008) Kathryn S Jones et al.   NATURE MEDICINE

Treatment of HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis: Toward Rational Targeted Therapy

(2008) Unsong Oh et al.   NEUROLOGIC CLINICS

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD40 and CD80/86 Act Synergistically to Regulate Inflammation and Mortality in Polymicrobial Sepsis

(2007) Anna Nolan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE