Article
Health Care Sciences & Services
Sung Chul Lim, Juhee Oh, Bo Young Hong, Seong Hoon Lim
Summary: Temporal lobe epilepsy (TLE) is a network disorder of the brain, characterized by hippocampal dysfunction. This study found significant changes in the volumes of the amygdala, hippocampus, and thalamus in patients with left TLE and hippocampal sclerosis (HS), while no abnormal diffusion properties associated with volume reduction were found in specific brain regions of patients with right TLE and HS.
Article
Pharmacology & Pharmacy
Soumil Dey, Aparna Banerjee Dixit, Manjari Tripathi, Ramesh Sharanappa Doddamani, Mehar Chand Sharma, Sanjeev Lalwani, Poodipedi Sarat Chandra, Jyotirmoy Banerjee
Summary: The study identified that levels of kynurenic acid were reduced and quinolinic acid levels were raised in the hippocampus of patients with MTLE-HS, along with abnormal glutamatergic activities. Altered metabolism of tryptophan-kynurenine pathway metabolites in the hippocampus could contribute to hyperglutamatergic tone in patients with MTLE-HS.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Oliver C. Kiersnowski, Gavin P. Winston, Lorenzo Caciagli, Emma Biondetti, Maha Elbadri, Sarah Buck, John S. Duncan, John S. Thornton, Karin Shmueli, Sjoerd B. Vos
Summary: Using quantitative susceptibility mapping (QSM) and transverse relaxation rate (R2*), we investigated brain alterations in patients with temporal lobe epilepsy (TLE) compared to healthy controls (HC). We found significant changes in susceptibility and R2* in various brain regions, indicating selective loss of neurons and iron redistribution in the hippocampi, increased iron content in the thalamus and putamen, and correlations with disease severity and cognitive test scores.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Shengkun Yu, Yifei Gu, Tianyu Wang, Long Mu, Haiyang Wang, Shi Yan, Aoweng Wang, Jiabin Wang, Li Liu, Hong Shen, Meng Na, Zhiguo Lin
Summary: This study revealed the molecular mechanisms of neuronal apoptosis in hippocampal sclerosis of intractable temporal lobe epilepsy patients through RNA sequencing and ceRNA network analysis, establishing a ceRNA network of lncRNA-mediated neuronal apoptosis in HS-TLE.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Kai Siebenbrodt, Vanessa Schuetz, Lara S. Costard, Valentin Neubert, Daniel Alvarez-Fischer, Kerstin Seidel, Bernd Schmeck, Sven G. Meuth, Felix Rosenow, Sebastian Bauer
Summary: This study quantified the release levels of hippocampal extracellular cytokines and chemokines in a rat model of mesial temporal lobe epilepsy with hippocampal sclerosis using microdialysis. The results showed that IL-1 beta release kinetics are consistent with its pro-epileptogenic properties, while IL-10 release kinetics suggest a counter-regulatory effect.
Article
Behavioral Sciences
Bulent Guven, Asli Ece Cilliler
Summary: Approximately half of patients with HS-MTLE had headaches, with about one third reporting migraine type headaches. This highlights the potential pathogenetic role of HS in the development of headaches, especially migraines, in patients with epilepsy. Further studies are necessary to determine if accompanying headaches, particularly migraine attacks, could be determining factors for HS-MTLE, and if they have a lateralizing value for HS.
EPILEPSY & BEHAVIOR
(2021)
Review
Clinical Neurology
Yuming Li, Peiwen Liu, Qiuxing Lin, Dong Zhou, Dongmei An
Summary: This study conducted a systematic review and meta-analysis to evaluate the seizure and memory outcomes of temporal lobe epilepsy with different hippocampal sclerosis subtypes. The results showed no significant difference in seizure freedom and improved outcome between different subtypes, and the long-term seizure outcome and memory impairment remained controversial.
Article
Clinical Neurology
Wenbiao Xiao, Zhiquan Yang, Xiaoxin Yan, Li Feng, Lili Long, Tian Tu, Na Deng, Wenjuan Chen, Bo Xiao, Hongyu Long, Yi Zeng
Summary: This study investigated proteomic alterations in the DG region of TLE-HS patients and found that differentially expressed proteins were enriched in areas such as synaptic vesicle, mitochondrion, and cell-cell adhesion. A key protein module related to oxidative phosphorylation was also identified.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Mengyi Guo, Jing Wang, Zhonghua Xiong, Xiongfei Wang, Yujiao Yang, Yifan Zhang, Chongyang Tang, Jing Zhang, Yuguang Guan, Fan Chen, Kun Yao, Pengfei Teng, Jian Zhou, Feng Zhai, Detlev Boison, Guoming Luan, Tianfu Li
Summary: Mesial temporal lobe epilepsy without hippocampal sclerosis (no-HS MTLE) patients have resistance to antiepileptic drugs, difficulties in precise seizure location, and poor surgical outcomes. This study found maladaptive changes in adenosine metabolism and neuronal pathology in no-HS MTLE patients, suggesting potential new therapeutic targets.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyu Wang, Xiaoting Luo, Haitao Pan, Xiaoyang Wang, Shangwen Xu, Hui Li, Zhiping Lin
Summary: Hippocampal radiomics models based on T2-FLAIR images can aid in the diagnosis of MTLE with HS, serving as biological markers for MTLE diagnosis.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Giulio E. Brancati, Chahinaz Rawas, Antoine Ghestem, Christophe Bernard, Anton I. Ivanov
Summary: The hippocampus in control mice shows spatial and time-dependent differences in energy metabolism along the dorsoventral axis, with changes in metabolic activity between morning and afternoon. In an epilepsy model, this spatiotemporal organization is significantly altered, with enhanced aerobic glycolysis in both dorsal and ventral parts in the afternoon when seizure probability is high. This suggests that energy metabolism is tailored to the functions performed by brain networks and alterations in pathological conditions may contribute to network dysfunctions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Sita Jayalakshmi, Sindhu Vasireddy, Jala Sireesha, Sudhindra Vooturi, Anuja Patil, Sai Sirisha, Rammohan Vadapalli, Y. B. V. K. Chandrasekhar, Manas Panigrahi
Summary: This study compared the long-term outcomes of surgery vs best medical management in patients with drug-resistant temporal lobe epilepsy associated with hippocampal sclerosis. The results showed that surgery was associated with higher rates of seizure freedom, resolution of epilepsy, and improvement in perceived life changes.
Article
Clinical Neurology
Franz Riederer, Rene Seiger, Rupert Lanzenberger, Ekateriana Pataraia, Gregor Kasprian, Lars Michels, Spyros Kollias, Thomas Czech, Johannes A. Hainfellner, Johannes Beiersdorf, Christoph Baumgartner
Summary: Hippocampal sclerosis is a common pathological substrate in drug resistant temporal lobe epilepsy, with different types defined based on patterns of cell loss. Automated volumetry of specific hippocampal subfields using high resolution MRI can predict patterns of cell loss in hippocampal sclerosis, particularly for type 1 HS.
Article
Clinical Neurology
Karl-Heinz Nenning, Olivia Fosleitner, Ernst Schwartz, Michelle Schwarz, Victor Schmidbauer, Gudrun Geisl, Christian Widmann, Susanne Pirker, Christoph Baumgartner, Daniela Prayer, Ekaterina Pataraia, Lisa Bartha-Doering, Georg Langs, Gregor Kasprian, Silvia B. Bonelli
Summary: The study found significant differences in connectivity between left and right TLE patients compared to healthy controls. Left TLE showed widespread impairment of task-positive language networks, while right TLE showed less pronounced alterations. Particularly, right TLE exhibited altered connectivity for cortical regions associated with the default mode network (DMN).
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Debayan Dasgupta, Roisin Finn, Aswin Chari, Davide Giampiccolo, Jane de Tisi, Aidan G. O'Keeffe, Anna Miserocchi, Andrew W. McEvoy, Sjoerd B. Vos, John S. Duncan
Summary: Recent work challenges the view that maximal posterior hippocampal resection improves seizure outcome. This study aims to assess whether resection of posterior hippocampal atrophy is associated with improved seizure outcome. The results show no statistically significant difference in seizure freedom outcomes in patients with or without complete resection of atrophic posterior hippocampus.
Article
Clinical Neurology
D. A. J. E. Lambrechts, R. J. A. de Kinderen, J. S. H. Vles, A. J. A. de Louw, A. P. Aldenkamp, H. J. M. Majoie
ACTA NEUROLOGICA SCANDINAVICA
(2017)
Article
Clinical Neurology
Danielle A. J. E. Lambrechts, Evelyn Brandt-Wouters, Pauline Verschuure, Hans S. H. Vles, Marian J. M. Majoie
Review
Clinical Neurology
Ben F. M. Wijnen, Ghislaine A. P. G. van Mastrigt, Silvia M. A. A. Evers, Olga Gershuni, Danielle A. J. E. Lambrechts, Marian H. J. M. Majoie, Debby Postulart, Bert A. P. Aldenkamp, Reina J. A. de Kinderen
Article
Behavioral Sciences
Francesca M. Snoeijen-Schouwenaars, Jans S. van Ool, In Y. Tan, Helenius J. Schelhaas, Marian H. J. M. Majoie
EPILEPSY & BEHAVIOR
(2017)
Article
Clinical Neurology
Ben F. M. Wijnen, Reina J. A. de Kinderen, Danielle A. J. E. Lambrechts, Debby Postulart, Albert P. Aldenkamp, Marian H. J. M. Majoie, Silvia M. A. A. Evers
Review
Clinical Neurology
Jo Sourbron, Sylvia Klinkenberg, Alfons Kessels, Helenius Jurgen Schelhaas, Lieuen Lagae, Marian Majoie
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2017)
Article
Clinical Neurology
Jo Sourbron, HoiYau Chan, Elisabeth A. Wammes-van der Heijden, Pim Klarenbeek, B. F. M. Wijnen, Gerrit-Jan de Haan, Hugo van der Kuy, Silvia Evers, Marian Majoie
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2018)
Letter
Clinical Neurology
H. J. M. Majoie, J. van Gaalen, D. M. L. Verstegen, G. A. P. G. van Mastrigt, J. Kleijnen, P. Alonso-Coello, G. Gartlehner, K. Ritchie, D. Service, M. Leone, S. M. A. A. Evers
EUROPEAN JOURNAL OF NEUROLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ellen Boswijk, Renee Franssen, Guy H. E. J. Vijgen, Roel Wierts, Jochem A. J. van Der Pol, Alma M. A. Mingels, Erwin M. J. Cornips, Marian H. J. M. Majoie, Wouter D. van Marken Lichtenbelt, Felix M. Mottaghy, Joachim E. Wildberger, Jan Bucerius
Article
Health Care Sciences & Services
Hoi Yau Chan, Ben F. M. Wijnen, Mickael Hiligsmann, Filip Smit, Loes A. M. Leenen, Marian H. J. M. Majoie, Silvia M. A. A. Evers
Summary: The study found that AQoL-8D has better ability to discriminate between known-groups and does not show a ceiling effect. It is recommended to use AQoL-8D alongside EQ-5D-5L in trials assessing the quality of life in patients with epilepsy or schizophrenia.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2022)
Article
Education, Special
J. J. L. Berkvens, S. Mergler, K. Beerhorst, P. Verschuure, I. Y. Tan, H. J. M. Majoie, J. P. W. van den Bergh
Summary: This study found that 67% of institutionalised children with epilepsy and intellectual disability had low bone mineral density, and 42% had a history of at least one fracture. Despite supplementation of calcium and vitamin D according to Dutch guidelines, the prevalence of bone disorders and fractures remains high in this population.
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2021)
Article
Clinical Neurology
Hoi Yau Chan, Ben F. M. Wijnen, Marian H. J. M. Majoie, Silvia M. A. A. Evers, Mickael Hiligsmann
Summary: This study suggests that, given current limited evidence, VNS and DBS are potentially cost-effective treatment strategies compared to CAU for patients with refractory epilepsy. However, results for DBS were heavily impacted by assumptions made to extrapolate nonresponse from the original trial, indicating a need for further empirical research to reduce uncertainty.
Article
Clinical Neurology
J. J. L. Berkvens, C. E. Wyers, D. Hans, S. Mergler, K. Beerhorst, P. Verschuure, I. Y. Tan, H. J. M. Majoie, J. P. van den Bergh
Summary: This longitudinal study aimed to assess trabecular bone scores (TBS) in institutionalized adults with refractory epilepsy and intellectual disability and study the association between TBS and incident fractures during seven years of follow-up. The results showed a high incidence of fractures and a significant decrease in TBS over the follow-up period, but TBS was not associated with incident fractures.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Review
Clinical Neurology
Hoi Yau Chan, Luca M. M. Janssen, Ben F. M. Wijnen, Mickael Hiligsmann, Marian H. J. M. Majoie, Silvia M. A. A. Evers
Summary: This study systematically identified and evaluated published economic evaluations on nonpharmacological interventions for drug-resistant epilepsy. The researchers applied specific criteria to search for relevant studies and assessed their quality. The study found that epilepsy surgery, vagus nerve stimulation, and responsive neurostimulation are cost-effective treatments for adults, while the cost-effectiveness of epilepsy surgery in children and the use of ketogenic diet were inconclusive.
Article
Clinical Neurology
Jessica Berkvens, Marian Majoie, Sandra Mergler, Kim Beerhorst, Pauline Verschuure, In Tan, Joop van den Bergh
