Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 277, Issue 1-2, Pages 140-144Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2014.09.015
Keywords
RIG-I-like receptors; RLRs; Multiple sclerosis; Association; Combinatorial effect
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Variation in genes encoding retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs) has been implicated in the pathogenesis of autoimmune disorders. We investigated if polymorphisms in the IFIH1, RIG-I, LGP2 and VISA genes influence the risk for multiple sclerosis (MS) in a German case-control cohort comprising 716 patients and 706 controls. Evaluation of 18 single nucleotide polymorphisms (SNPs) in the four genes did not reveal significant single-SNP associations with MS risk, but two VISA polymorphisms were modestly associated with age of onset. Further, we provide initial evidence for combinatorial effects of polymorphic variants in the RIG-I, LGP2 and IFIH1 genes on MS risk. (C) 2014 Elsevier B.V. All rights reserved.
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