Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 267, Issue 1-2, Pages 35-42Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2013.12.005
Keywords
CNS tumor; CpG-ODN; Treg; NK cells
Categories
Funding
- institutional grants from the Inserm
- University of Angers
- Ligue contre le Cancer (Comite departemental du Maine et Loire, Loire atlantique, de Sarthe et de Vendee)
- Canceropole Grand-Ouest
- Association pour la Recherche contre le Cancer
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Using brain lymphoma model, we demonstrate that immunotherapy combining Treg depletion (using anti-CD25 mAb PC61) followed by intracranial CpG-ODN administration induced tumor rejection in all treated mice and led to the establishment of a memory antitumor immune response in 60% of them. This protective effect was associated with a recruitment of NK cells and, to a lesser extent, of dendritic cells, B cells and T lymphocytes. NK cell depletion abolished the protective effect of the treatment, confirming a major role of NK cells in brain tumor elimination. Each treatment used alone failed to protect brain tumor bearing mice, revealing the therapeutic benefit of combining Treg depletion and local CpG-ODN injection. (C) 2014 Elsevier B.V. All rights reserved.
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