Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 263, Issue 1-2, Pages 43-54Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2013.07.019
Keywords
Central nervous system; Neuroimmunology; CD4(+) and CD8(+) T cells; Inflammation; Interleukin
Categories
Funding
- U.S. National Institutes of Health [NS064932, AI 47249, AI49360, AI082966]
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Acute coronavirus encephalomyelitis is controlled by T cells while humoral responses suppress virus persistence. This study defines the contribution of interleukin (IL)-21, a regulator of T and B cell function, to central nervous system (CNS) immunity. IL-21 receptor deficiency did not affect peripheral T cell activation or trafficking, but dampened granzyme B, gamma interferon and IL-10 expression by CNS T cells and reduced serum and intrathecal humoral responses. Viral control was already lost prior to humoral CNS responses, but demyelination remained comparable. These data demonstrate a critical role of IL-21 in regulating CNS immunity, sustaining viral persistence and preventing mortality. (C) 2013 Elsevier B.V. All rights reserved.
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