Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 260, Issue 1-2, Pages 47-54Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2013.04.006
Keywords
Glioma; Astrocytoma; Chemokine; Receptor; Tumor stem cell
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Funding
- Interdisciplinary Centre of Clinical Research (IZKF) Aachen, Germany
- Deutsche Forschungsgemeinschaft [HE3400/5-1, ME 758/10-1]
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Since chemokines and their receptors play a pivotal role in tumors, we investigated the CXCL16-CXCR6-axis in human astroglial tumors. The transmembrane chemokine CXCL16 is heavily expressed by tumor, microglial and endothelial cells in situ and in vitro. In contrast, the receptor CXCR6 is restricted in glioblastomas to a small subset of proliferating cells positive for the stem-cell markers Musashi, Nanog, Sox2 and Oct4. In particular, the vast majority (about 90%) of Musashi-positive cells stained also for CXCR6. Thus, CXCL16 is highly expressed by glial tumor and stroma cells whereas CXCR6 defines a subset of cells with stem cell character. (C) 2013 Elsevier B.V. All rights reserved.
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