Article
Biochemistry & Molecular Biology
Benjamin Lau, Hossein Fazelinia, Ipsita Mohanty, Serena Raimo, Margarita Tenopoulou, Paschalis-Thomas Doulias, Harry Ischiropoulos
Summary: This study identified and analyzed S-nitrosocysteine residues in mouse heart proteins, with a significant enrichment of these modifications in mitochondrial proteins participating in metabolism. The major functional pathways impacted by protein S-nitrosylation include regulatory proteins in glycolysis, TCA cycle, oxidative phosphorylation, and ATP production. The meta-analysis of the proteomic data supports the hypothesis that nitric oxide signaling via protein S-nitrosylation is a regulator of cardiomyocyte metabolism to ensure optimal cardiac function.
Article
Clinical Neurology
Mattia Fonderico, Tiziana Biagioli, Luisa Lanzilao, Angelo Bellinvia, Roberto Fratangelo, Luisa Pasto, Elio Prestipino, Lorenzo Razzolini, Laura Tudisco, Andrea Ginestroni, Luisa Vuolo, Enrico Fainardi, Clara Ballerini, Emilio Portaccio, Maria Pia Amato
Summary: This study confirms the prognostic role of ITMS in multiple sclerosis, showing that patients with ITMS are more likely to experience a second clinical attack, especially those with relapsing-remitting MS.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Clinical Neurology
Johanna Oechtering, Therese Lincke, Sabine Schaedelin, Bernhard F. Decard, Aleksandra Maceski, Annette Orleth, Stephanie Meier, Eline Willemse, Arabella Buchmann, Michael Khalil, Tobias Derfuss, Pascal Benkert, Ingmar Heijnen, Axel Regeniter, Stefanie Muller, Lutz Achtnichts, Patrice Lalive, Anke Salmen, Caroline Pot, Claudio Gobbi, Ludwig Kappos, Cristina Granziera, David Leppert, Regina Schlaeger, Johanna M. Lieb, Jens Kuhle
Summary: In early multiple sclerosis, intrathecal IgM synthesis is strongly associated with spinal cord manifestation and more pronounced neuroaxonal injury, suggesting a distinct clinical phenotype and pathophysiology.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Enric Monreal, Susana Sainz de la Maza, Lucienne Costa-Frossard, Paulette Walo-Delgado, Javier Zamora, Jose Ignacio Fernandez-Velasco, Noelia Villarrubia, Mercedes Espino, Daniel Lourido, Paloma Lapuente, Inmaculada Toboso, Jose Carlos Alvarez-Cermeno, Jaime Masjuan, Luisa Maria Villar
Summary: The study suggests that measuring lipid-specific IgM oligoclonal bands can predict disease progression in MS patients, especially those with CIS, over a follow-up of at least 2 years.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Kamila Revendova, David Zeman, Pavlina Kusnierova, Radovan Bunganic, Pavla Hanzlikova, Katerina Karasova, Ondrej Volny, Michal Bar
Summary: This prospective cohort study did not demonstrate that intrathecal IgM synthesis is a risk factor for a second relapse or MRI activity, and it was not associated with higher disability in patients after the first demyelinating event.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Review
Neurosciences
Mattia Fonderico, Emilio Portaccio, Lorenzo Razzolini, Luisa Pasto, Angelo Bellinvia, Ilaria Addazio, Matteo Betti, Maria Grazia Aprea, Clara Ballerini, Tiziana Biagioli, Maria Pia Amato
Summary: The presence of intrathecal IgM synthesis (ITMS) is associated with an aggressive clinical course of multiple sclerosis (MS), being higher in relapsing-remitting (RR) patients. The risk of second relapse is higher in OCGBs positive patients, but much higher in ITMS positive patients. This study suggests that the risk of a second relapse may be related to the presence of intrathecal IgM to some extent.
Article
Clinical Neurology
Igal Rosenstein, Markus Axelsson, Lenka Novakova, Clas Malmestroem, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Summary: While KFLC index is a useful diagnostic biomarker in multiple sclerosis (MS), its prognostic properties are less explored. This study found that high baseline KFLC index is predictive of PIRA, evidence of disease activity (EDA-3), and overall worse prognosis in MS.
JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Jessica Castillo-Villalba, Sara Gil-Perotin, Raquel Gasque-Rubio, Laura Cubas-Nunez, Sara Carratala-Bosca, Carmen Alcala, Carlos Quintanilla-Bordas, Francisco Perez-Miralles, Cristina Ferrer, Antonio Canada Martinez, Jordi Tortosa, Luis Solis-Tarazona, Luisa Campos, Alberto Leivas, Begona Laiz Marro, Bonaventura Casanova
Summary: This study analyzed the relationship between cerebrospinal kappa free light chain (KFLC)-index and other multiple sclerosis (MS) biomarkers, and explored its prognostic role. The results showed that KFLC-index correlated with other indexes, and a high KFLC-index was associated with poorer prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Charlotte Hvaring, Noor Alawad, Oyvind Salvesen, Harald Hovdal, Linda R. White, Anne I. Boullerne
Summary: This pilot study examines the role of IgM bands in the cerebrospinal fluid of multiple sclerosis patients, and the results suggest that these bands may have prognostic potential for relapsing-remitting multiple sclerosis. However, further larger studies are needed to validate these findings.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Hsiuying Wang
Summary: Multiple sclerosis (MS) is a chronic disease affecting the central nervous system, with up to 50% of patients experiencing depressive disorders. Major depression (MD) is a serious comorbidity of MS, potentially involving various dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Massimiliano Castellazzi, Caterina Ferri, Ginevra Tecilla, Andre Huss, Paola Crociani, Gaetano Desina, Gianvito Barbella, Alice Piola, Samantha Permunian, Makbule Senel, Maurizio Leone, Hayrettin Tumani, Maura Pugliatti
Summary: The presence of variables affected by sex and age in multiple sclerosis and clinically isolated syndrome patients was assessed. It was found that sex and age influenced the blood-CSF barrier function and CSF protein content, but had no effect on intrathecal IgG synthesis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Bastian Weiss, Alexander Pichler, Anna Damulina, Arabella Buchmann, Sonja Hochmeister, Thomas Seifert-Held, Christian Enzinger, Juan-Jose Archelos, Michael Khalil
Summary: This study evaluated the clinical significance of quantitative kappa free light chains (k-FLC) in patients with an isolated band in the cerebrospinal fluid (CSF). The results showed that positive k-FLC can indicate the possibility of neuroinflammatory diseases in patients with an isolated band in isoelectric focusing (IEF). Therefore, measuring k-FLC can provide support in the diagnosis of neurological diseases.
Article
Immunology
Christina Noll, Michael Hiltensperger, Lilian Aly, Rebecca Wicklein, Ali Maisam Afzali, Christian Mardin, Christiane Gasperi, Achim Berthele, Bernhard Hemmer, Thomas Korn, Benjamin Knier
Summary: This study found that rarefication of the retinal vasculature during RRMS is associated with higher frequencies of activated B cells and higher levels of pro-inflammatory cytokines in the cerebrospinal fluid. Furthermore, vessel loss in the retina is linked to future disability worsening.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Mathematical & Computational Biology
Wang-Ren Qiu, Qian-Kun Wang, Meng-Yue Guan, Jian-Hua Jia, Xuan Xiao
Summary: Two models were proposed for identifying S-nitrosylation proteins and their PTM sites. By extracting features from protein sequences and using synthetic minority oversampling technique to balance data sets, state-of-the-art classifiers and feature fusion strategies were employed, leading to promising results in five-fold cross-validation tests.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Ursula Munoz, Cristina Sebal, Esther Escudero, Maria Isabel Garcia Sanchez, Elena Urcelay, Asier Jayo, Rafael Arroyo, Maria A. Garcia-Martinez, Roberto Alvarez-Lafuente, Maria C. Sadaba
Summary: In this study, a new method for detecting IgA concentration was developed, and it was found that the incidence of IAS in MS patients was higher than previously estimated, and was not related to serum IgA concentration. Patients with clinically isolated syndrome had a particularly high incidence of IAS.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Charlotte Hvaring, Noor Alawad, Oyvind Salvesen, Harald Hovdal, Linda R. White, Anne I. Boullerne
Summary: This pilot study examines the role of IgM bands in the cerebrospinal fluid of multiple sclerosis patients, and the results suggest that these bands may have prognostic potential for relapsing-remitting multiple sclerosis. However, further larger studies are needed to validate these findings.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
