Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 255, Issue 1-2, Pages 81-84Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2012.10.009
Keywords
Multiple sclerosis; IL-17; IL-23; IL-26; IL-17R; IL-23R
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Funding
- Merck Serono
- Hacettepe University [010D02101008]
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Th17-related cytokines (IL-17, IL-23, and IL-26) and receptors (IL-17R and IL-23R) were evaluated in MS patients under immunomodulatory IFN-beta 1 therapy during a 2 year follow-up. Before the initiation of treatment, no significant difference was found in cytokine or receptor expression between controls and MS patients. Of the three cytokines evaluated, IL-26 was the highest in the patients' sera. The amount of IL-17 and CD13(+)IL-17R(+) cells was steadily decreased whereas IL-23 and IL-26 levels were gradually increased with IFN-beta 1 therapy. The patients in progressive phase had very high levels of IL-17. Th17-associated parameters should be considered in the immunomodulatory IFN-beta 1 therapy of MS. (C) 2012 Elsevier B.V. All rights reserved.
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