Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 245, Issue 1-2, Pages 98-101Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2012.02.005
Keywords
Interleukin-28 receptor alpha; Interferon-lambda; Multiple sclerosis; Polymorphism
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Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis. (C) 2012 Elsevier B.V. All rights reserved.
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