Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 224, Issue 1-2, Pages 8-12Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2010.05.019
Keywords
Chemokines; Chemokine receptors; Glioma; Invasion; Tumor-infiltrating leukocytes
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Funding
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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Increasing pieces of evidence indicate that the chemokine system influences several aspects of brain physiology and pathology. A deregulated chemokine expression pattern is observed during neurological diseases, including multiple sclerosis and brain tumor. Gliomas are the most common primary tumors affecting human central nervous system (CNS). Chemokines expressed by stromal cells or endogenously produced by glioma cells may influence tumor cell migration, invasion, proliferation, angiogenesis and immune cell infiltration in the tumor mass. Herein we focus on chemokines and chemokine receptors expressed by glioma cells and their role in the regulation of glioma cell functional behaviour, including its ability to attract immune cells. (C) 2010 Elsevier B.V. All rights reserved.
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