Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 221, Issue 1-2, Pages 73-80Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.02.005
Keywords
T-cells; MS; Neuroimmunology; T-cell receptors; Homeostasis
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We investigated naive CD4 T-cell homeostasis in relapsing-remitting multiple sclerosis (RRMS). Quantification of signal joint T-cell receptor excision circles in FACS-isolated CD31 hi cells, which correspond closely to CD4 recent thymic emigrants (RTEs), indicates that young patients have reduced generation of CD4 RTEs compared to age-matched controls. In RRMS, compared to controls, CXCR4 analyses indicate age-associated thymic output of progressively immature CD4 RTEs, and Ki-67 data demonstrate altered T-cell proliferative responses that fail to maintain naive CD4 T-cell numbers with age. Thus. RRMS patients have early thymic involution with compensatory homeostatic peripheral T-cell proliferative responses that may predispose patients to autoreactivity. (C) 2010 Elsevier B.V. All rights reserved.
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