Article
Immunology
Cinta Lleixa, Lorena Martin-Aguilar, Elba Pascual-Goni, Teresa Franco, Marta Caballero, Noemi de Luna, Eduard Gallardo, Xavier Suarez-Calvet, Laura Martinez-Martinez, Jordi Diaz-Manera, Ricard Rojas-Garcia, Elena Cortes-Vicente, Joana Turon, Carlos Casasnovas, Christian Homedes, Gerardo Gutierrez-Gutierrez, Maria Concepcion Jimeno-Montero, Jose Berciano, Maria Jose Sedano-Tous, Tania Garcia-Sobrino, Julio Pardo-Fernandez, Celedonio Marquez-Infante, Inigo Rojas-Marcos, Ivonne Jerico-Pascual, Eugenia Martinez-Hernandez, German Moris de la Tassa, Cristina Dominguez-Gonzalez, Candido Juarez, Isabel Illa, Luis Querol
Summary: This study found that GBS patients have a heterogeneous repertoire of autoantibodies targeting nerve cells and structures. Gangliosides are the most frequent antigens in GBS patients and have prognostic value. Further antigen-discovery experiments may elucidate other potential antigens in GBS.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Johanna I. Hamel, Eric L. Logigian
Summary: This study retrospectively reviewed cases from 1999 to 2020 to describe the clinical, micronutrient, and electrophysiologic spectra and prognosis of acute nutritional axonal neuropathy (ANAN). The results showed that ANAN has a wide spectrum of manifestations and specific micronutrient deficiencies or risk factors do not predict neuropathy subtype. The prognosis of ANAN is guarded due to slow recovery of independent ambulation and residual neuropathic pain.
Editorial Material
Clinical Neurology
Sina Marzoughi, Laura Marulanda, Dian Ngo, Tychicus Chen
Summary: This case presents an atypical motor axonal neuropathy with asymmetric paralysis, initially preserved reflexes, rapid progression, and cardiac dysfunction independent of dysautonomia.
Editorial Material
Clinical Neurology
Jonah P. Zuflacht, Aimee K. Boegle
Summary: CIDP may present acutely, resembling GBS.
Article
Clinical Neurology
Jiting Zhu, Yuanyuan Zhang, Runyun Li, Yi Lin, Ying Fu, Yaping Yan, Wenli Zhu, Ning Wang, Zaiqiang Zhang, Guorong Xu
Summary: This study investigated the diagnostic efficiency of a novel immunoblotting detection assay for anti-ganglioside antibodies (AGAs) in Guillain-Barre syndrome (GBS). The results showed a high detection rate of AGAs in GBS patients, with specific assistance in diagnosing the AMAN subtype.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Haihui Luan, Peng Zhang, Mingqing Zhen, Mei Li, Xiaowei Wang, Jianghua Xu
Summary: This study reports a rare case of recurrent GBS with different phenotypes and three species of ganglioside antibodies.
Article
Medicine, General & Internal
Mateus Santana do Rosario, Pedro Antonio Pereira de Jesus, Daniel Santana Farias, Marco Antonio Caires Novaes, Marcos Vinicius Lima Oliveira Francisco, Cleiton Silva Santos, Daniel Moura, Fernanda Washington de M. Lima, Luiz Carlos Junior Alcantara, Isadora Cristina de Siqueira
Summary: This study reports on GBS and MFS cases associated with arboviruses during the Zika virus outbreak in Salvador, Brazil. The presence of multiple arboviral infections was found to be associated with GBS and MFS, highlighting the importance of diagnosis.
FRONTIERS IN MEDICINE
(2022)
Article
Neurosciences
Qing Zeng, Juan Li, Shu-Xing Feng, Pei-Yao Xiao, Yi-Fan Zheng, Cheng Zhang, Song-Jie Liao
Summary: This study describes the clinical characteristics of anti-GQ1b antibody syndrome with visual impairment, expanding the clinical spectrum of this syndrome. It emphasizes the importance of physical and ophthalmological examination in exploring the pathogenesis and treatment of anti-GQ1b antibody syndrome.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Immunology
Margherita Bellucci, Francesco Germano, Stefano Grisanti, Chiara Castellano, Francesco Tazza, Emanuela Maria Mobilia, Davide Visigalli, Giovanni Novi, Federico Massa, Silvia Rossi, Paolo Durando, Corrado Cabona, Angelo Schenone, Diego Franciotta, Luana Benedetti
Summary: This article reports a case in which a patient developed GBS symptoms after COVID-19 infection, recovered after treatment, but experienced a recurrence of GBS after receiving the COVID-19 vaccine. Based on this case and previous observations, there may be a possible causal link between SARS-CoV-2 and GBS.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Clinical Neurology
Jeffrey A. Allen
Summary: With every influenza vaccination, the question of previous Guillain-Barre syndrome (GBS) history is asked, and vaccination is typically advised against for those with GBS. The topic is widely discussed with strong opinions for or against vaccination within patient and physician networks. The COVID-19 pandemic has heightened concerns among the inflammatory neuropathy community and clinicians caring for GBS and CIDP patients, given the global scale of SARS-CoV-2 vaccinations.
Review
Immunology
Miao Yu, Shuang Nie, Yue Qiao, Ying Ma
Summary: This study retrospectively analyzed reported Guillain-Barre syndrome (GBS) cases occurring after COVID-19 vaccination. The analysis revealed that GBS mostly occurred after the first dose of the vaccination (90%), particularly with DNA vaccines (63%). It was more common in middle-aged and elderly individuals (mean age: 54.5 years) and in men (60%). The mean time from vaccination to onset was 12.3 days. Monitoring for GBS following vaccination is recommended to establish the true incidence and association between GBS and COVID-19 vaccination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Alisa Corrado, Grace Yoshiba, Megan Buranosky, Zakary Woods, Julie Wohrley, Lubov Romantseva, Ashley Wolf
Summary: A 43-day-old male infant presented with decreased activity and oral intake, initially diagnosed with bronchiolitis. However, as his condition worsened, he developed neurological deficits and underwent an extensive workup, leading to a surprising diagnosis.
Article
Immunology
Weiqian Yan, Cheng Zhao, Hainan Zhang, Zhiping Hu, Chunyu Wang
Summary: This case report highlights the association of mGluR5 antibody with Guillain-Barre syndrome and severe headache, expanding the spectrum of mGluR5-associated disorders beyond limbic encephalitis and Hodgkin's lymphoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Xintong Li, Berta Raventos, Elena Roel, Andrea Pistillo, Eugenia Martinez-Hernandez, Antonella Delmestri, Carlen Reyes, Victoria Strauss, Daniel Prieto-Alhambra, Edward Burn, Talita Duarte-Salles
Summary: The study found no safety signal between COVID-19 vaccines and immune mediated neurological events such as Bell's palsy, encephalomyelitis, Guillain-Barre syndrome, and transverse myelitis. However, an increased risk of these events was observed for individuals with SARS-CoV-2 infection.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Review
Medicine, General & Internal
Ahsun Rizwan Siddiqi, Tehrim Khan, Muhammad Junaid Tahir, Muhammad Sohaib Asghar, Md. Saiful Islam, Zohaib Yousaf
Summary: This case report describes a rare case of Miller Fisher syndrome (MFS) occurring after COVID-19 vaccination and highlights the need for further research to establish a temporal association.