Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 218, Issue 1-2, Pages 116-119Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.10.018
Keywords
Guillain-Barre syndrome; TLR4 polymorphism; Campylobacter jejuni; Lipopolysaccharide
Categories
Funding
- Indian Council of Medical Research (ICMR), New Delhi, India [5/3/ 3/24/2006-ECD-1, 80/569/2007-ECD-1, 09/590 (0138)/2007-EMR-1]
- Council for Scientific and Industrial Research, New Delhi, India
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Molecular mimicry between Campylobacter jejuni lipopolysaccharide and host gangliosides induces an immune response leading to axonal damage and Guillain-Barre syndrome (GBS). TLR polymorphisms are associated with many autoimmune diseases. The role of the TLR4 gene in GBS susceptibility largely remains unknown. We investigated TLR4 polymorphism in GBS. One hundred and twenty GBS patients and 150 healthy controls were included. TLR4 (Asp299Gly and Thr399Ile) genes were studied by PCR-RFLP. TLR4 (Asp299Gly) polymorphism was significantly associated with GBS (p, 0.045; OR, 8.75; 95% CI, 1.05-72.88); only acute motor axonal neuropathy (AMAN) was associated with Gly299Gly homozygote (p, 0.027; OR, 12.40; 95% CI, 1.33-115.77) and Thr399Ile (p, 0.019 OR. 3.42; 95% G, 1.22-9.54) heterozygote, and TLR4399Ile allele (p, 0.045; OR, 2.63; 95% CI, 1.02-6.75) compared to controls. In conclusion, TLR4 (Asp299Gly) polymorphism is associated with an increased susceptibility to GBS. Besides Asp299Gly, AMAN subtype is also associated with Thr399Ile polymorphism. (C) 2009 Elsevier B.V. All rights reserved.
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