Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 225, Issue 1-2, Pages 118-122Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.04.020
Keywords
Neural cell adhesion molecule; ELISA; Multiple sclerosis; Cerebrospinal fluid; Validation; Nerve regeneration
Categories
Funding
- National MS Society
Ask authors/readers for more resources
Neural cell adhesion molecule (NCAM) is important for neuronal growth and repair. Here we describe the development and validation of a sensitive ELISA for NCAM using commercially available reagents. The measurable range of NCAM ELISA is 16-500 ng/mL, with a constant coefficient-of variation and good parallelism between the reference standard curve and CSF. CSF NCAM was measured in 36 benign-intracranial hypertension, 51 multiple sclerosis, 27 neuropathy, 37 Alzheimer's disease, 12 cognitive impairment, 15 motoneurone disease, 13 meningitis, 17 encephalitis, and 17 control cases. Significant reductions were found between controls and multiple sclerosis, Alzheimer's disease and meningitis. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available