Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 222, Issue 1-2, Pages 87-89Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.02.015
Keywords
GAD65; Ro52; Depression; Autoimmunity; Psychomotor disturbance
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Funding
- National Institute of Dental and Craniofacial Research, the National Institutes of Health
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Autoimmune disease and/or autoantibodies have been reported in mood disorder patients. We screened for autoantibodies to glutamic acid decarboxylase (GAD65), thyroid peroxidase (TPO), gastric H+/K+ ATPase (ATP4B), and Ro52 in a psychiatric patient cohort. A 24-year-old woman with major depressive disorder (MOD) with reduced psychomotor activity was identified with unusually high serum GAD65 and Ro52 autoantibody titers. Anti-GAD65 and anti-Ro52 autoantibodies were also elevated in the CSF from this patient. Longitudinal examination revealed a four-fold increase in anti-GAD65 serum antibody titers which correlated with exacerbation of psychomotor symptomatology. These results suggest the possibility that CNS autoimmunity may be responsible for the psychomotor impairment in this MOD patient. Published by Elsevier B.V.
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