Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 215, Issue 1-2, Pages 73-83Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.08.009
Keywords
Myoblasts; Progenitor cells; Neurons; Multiple Sclerosis; Experimental Autoimmune Encephalomyelitis; Glatiramer acetate
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Funding
- Association Francaise coutre les Myophataies (AFM) France
- Teva Pharmaceutical Industries Israel
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This study explores the potential of non-neural progenitor cells for CNS cell therapy. Muscle progenitor cells (MPCs), transplanted either intraventricularly or intraperitonealy, incorporated into the CNS of EAE-induced but not of naive mice. Some of the migrating MPCs expressed the neuronal marker beta-III-Tubulin and gained neuronal morphology. Co-treatment of transplanted mice with the immunomodulatory agent glatiramer acetate (GA, Copaxone) resulted in improved MPCs incorporation and differentiation towards the neuronal pathway. The therapeutic potential of myogenic progenitor cells was demonstrated by amelioration of clinical symptoms and reduced mortality in EAE mice, as well as by expression of IL-10, TGF-beta, and the neurotrophin-BDNF. (C) 2009 Elsevier B.V. All rights reserved.
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