Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 213, Issue 1-2, Pages 112-122Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.05.008
Keywords
Mycobacterial infection; CNS; BCG; IL-17; IFN-gamma; Regulatory T cells; Dendritic cells and microglia
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Funding
- U.S. Public Health Service National Institutes of Health Research [NS-37570]
- NMSS [PP 1429]
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To study whether cerebral mycobacterial infection induces granuloma and protective immunity similar to systemic infection, we intracerebrally infected mice with Mycobacterium bovis bacilli Calmette-Guerin. Granuloma and IFN-gamma(+)CD4(+) T cell responses are induced in the central nervous system (CNS) similar to periphery, but the presence of IFN-gamma IL-17 double-positive CD4(+) T cells is unique to the CNS. The major CNS source of TNF-alpha is microglia, with modest production by CD4(+) T cells and macrophage. Protective immunity is accompanied by accumulation of Foxp3(+)CD4(+) T cells and PD-L2(+) dendritic cells, suggesting that both inflammatory and anti-inflammatory responses develop in the CNS following mycobacterial infection. (C) 2009 Elsevier B.V. All rights reserved.
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