Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 213, Issue 1-2, Pages 12-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.06.007
Keywords
ICAM-5; Chemokines; HSV-1; Neurological disorder; HSE
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Funding
- National Institute of Health/NINDS [NS049556]
- Emory Neuroscience NINDS Core Facilities (ENNCF) [P30 NS055077]
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Chemokines are important in HSE development in the CNS but underlying regulatory events are unknown. Two-hybrid binding assays identified that intercellular adhesion molecule 5 (ICAM-5), an immune modulator in the CNS, interacted with neurovirulence factor, UOL, of HSV-1. Viral load and interleukin levels were similar in UOL deletion virus (Delta UOL), and wild type virus infected mouse brains. However, higher numbers of lymphocytes, but unaltered soluble ICAM-5 and chemokine levels were detected in Delta UOL infected mouse brains. In contrast, lower lymphocyte numbers, reduced soluble ICAM-5, and higher chemokine levels were detected in wild type virus infected brains. Our results suggest that ICAM-5 plays a critical role in modulating chemokine production in the CNS. (C) 2009 Elsevier B.V. All rights reserved.
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