Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 200, Issue 1-2, Pages 1-10Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.05.017
Keywords
Dendritic cells; Vaccines; Amyloid beta-peptide; Alzheimer's disease; Epitopes; Th1 Cells; Th2 cells; Inflammation
Categories
Funding
- Florida Alzheimer's Disease Research Center [P50AG025711]
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Vaccines using bone marrow-derived dendritic cells (DCs) sensitized to A beta 1-42 peptide and other mutant peptides were tested on BALB/c and APP(sw) transgenic mice. Wild type A beta 1-42-sensitized DC vaccine (DCSV) produced no response, but all peptides with a T-cell epitope mutation induced antibody responses without inflammation. DCSV with A beta 1-25 peptide with mutated T-cell epitope failed to induce antibody response, while DCSV with A beta 1-35 with mutated T-cell epitope produced a strong antibody response. The entire T-cell epitope is required in a DC vaccine to induce antibody response. DCSV with A beta peptide carrying the entire mutant T-cell epitope may be an appropriate vaccine against AD. (c) 2008 Elsevier B.V. All rights reserved.
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