Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 199, Issue 1-2, Pages 94-103Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.05.011
Keywords
chemokines; CREB; MAP kinase pathways; hippocampal neurons; CCR2
Categories
Funding
- NIH [MH63712, P30 MH62261]
- Korea Research Foundation [KRF-2006-531-E00015]
- Plant Diversity Research Center [PF06216-00]
- Ministry of Science and Technology of Korean government
- National Research Foundation of Korea [04-2006-00-013-00, 2006-531-E00015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Emerging evidence indicates that chemokines can regulate both the physiology and biochemistry of CNS neurons and glia. In the current study, Western blot analysis showed that in rat hippocampal neuronal/glial cultures the signal transduction pathway activated by CCL2, a chemokine expressed in the normal brain and at elevated levels during neuroinflammation, involves a G-protein coupled receptor, p38 MAPK as well as its immediate Upstream kinase MKK3/6, and the downstream transcription factor CREB. ERK 1/2 and the transcription factors STAT1 and STAT3 do not play a prominent role. CCL2 also altered Ca2+ influx and synaptic network activity in the hippocampal neurons. These results suggest an important role for p38 MAPK and CREB in hippocampal actions of CCL2. (C) 2008 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available