Journal
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
Volume 7, Issue 4, Pages 731-739Publisher
SPRINGER
DOI: 10.1007/s11481-012-9411-y
Keywords
HIV; NeuroAIDS; Astrocytes; Wnt signaling
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Funding
- National Institutes of Health [R01 NS060632, R03 DA 026723, R01 DA 033966, PO1A1082971]
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Considerable studies have evaluated the interaction between Wnt/beta-catenin signaling and numerous cellular processes. Emerging findings now demonstrate that Wnt/beta-catenin signaling interacts with the life cycle of the Human Immunodeficiency Virus type 1 (HIV-1). Wnt/beta-catenin is a restrictive pathway to HIV replication in multiple target cells including peripheral blood mononuclear cells and astrocytes. The molecular interaction between Wnt/beta-catenin signaling and HIV has been evaluated in astrocytes because they express robust level of this pathway. The cross talk that occurs between these two components has significant biologic consequences to HIV-mediated neuropathogenesis. This perspective highlights current knowledge regarding the interaction between Wnt/beta-catenin signaling and HIV, the interplay between these two pathways as it impacts key features of NeuroAIDS, and provides an assessment of knowledge gaps in the field that could propel our understanding of this interaction to inform novel strategies to exploit Wnt signaling for therapeutic intervention in HIV/NeuroAIDS.
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