Anti-Viral and Anti-Inflammatory Mechanisms of the Innate Immune Transcription Factor Interferon Regulatory Factor 3: Relevance to Human CNS Diseases

Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages

(2014) J. P. Luyendyk et al.   JOURNAL OF IMMUNOLOGY

Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses

(2011) Glen N Barber   CURRENT OPINION IN IMMUNOLOGY

Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*

(2011) Leonid Tarassishin et al.   GLIA

Cytoplasmic DNA innate immune pathways

(2011) Glen N. Barber   IMMUNOLOGICAL REVIEWS

miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

(2011) Ana L. Cardoso et al.   IMMUNOLOGY

Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway

(2011) Leonid Tarassishin et al.   Journal of Neuroinflammation

Varicella-Zoster Virus Immediate-Early Protein ORF61 Abrogates the IRF3-Mediated Innate Immune Response through Degradation of Activated IRF3

(2011) H. Zhu et al.   JOURNAL OF VIROLOGY

STING-dependent signaling

(2011) Glen N Barber   NATURE IMMUNOLOGY

Negative Regulation of Interferon-β Gene Expression during Acute and Persistent Virus Infections

(2011) Junqiang Ye et al.   PLoS One

Host Genetic Risk Factors for West Nile Virus Infection and Disease Progression

(2011) Abigail W. Bigham et al.   PLoS One

IFI16 Protein Mediates the Anti-inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes

(2011) Sudhakar Veeranki et al.   PLoS One

Aberrant expression of interferon regulatory factor 3 in human lung cancer

(2010) Takayuki Tokunaga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-1: Discoveries, controversies and future directions

(2010) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1

(2010) S. M. Joung et al.   JOURNAL OF IMMUNOLOGY

Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation

(2010) Philipp Günzl et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interferon Regulatory Factor 3-Dependent Pathways Are Critical for Control of Herpes Simplex Virus Type 1 Central Nervous System Infection

(2010) V. D. Menachery et al.   JOURNAL OF VIROLOGY

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

(2009) Andreas Junker et al.   BRAIN

The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs

(2009) Ariadne Androulidaki et al.   IMMUNITY

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Systemic Lipopolysaccharide Protects the Brain from Ischemic Injury by Reprogramming the Response of the Brain to Stroke: A Critical Role for IRF3

(2009) B. Marsh et al.   JOURNAL OF NEUROSCIENCE

Human Immunodeficiency Virus Type 1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells

(2009) B. P. Doehle et al.   JOURNAL OF VIROLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Autoinflammatory Disease Due to Homozygous Deletion of theIL1RNLocus

(2009) Sreelatha Reddy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-1β and the Autoinflammatory Diseases

(2009) Charles A. Dinarello   NEW ENGLAND JOURNAL OF MEDICINE

Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1  in human monocytes and multiple sclerosis

(2009) D. Burger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR3 and TLR4 are innate antiviral immune receptors in human microglia: Role of IRF3 in modulating antiviral and inflammatory response in the CNS

(2009) Hyeon-Sook Suh et al.   VIROLOGY

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

(2008) Jean-Martin Beaulieu et al.   Annual Review of Pharmacology and Toxicology

Nuanced roles of cytokines in three major human brain disorders

(2008) Lawrence Steinman   JOURNAL OF CLINICAL INVESTIGATION

Characterization of retinoic acid–inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus

(2008) Samantha R Furr et al.   JOURNAL OF NEUROVIROLOGY

IRF-3 Activation by Sendai Virus Infection Is Required for Cellular Apoptosis and Avoidance of Persistence

(2008) K. Peters et al.   JOURNAL OF VIROLOGY

Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus

(2008) M Akahoshi et al.   LUPUS

MicroRNAs: new regulators of immune cell development and function

(2008) David Baltimore et al.   NATURE IMMUNOLOGY

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

(2008) M. Cosenza-Nashat et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

HIV-1 Activates Macrophages Independent of Toll-Like Receptors

(2008) Joseph N. Brown et al.   PLoS One

Primer: inflammasomes and interleukin 1β in inflammatory disorders

(2008) Leigh D Church et al.   Nature clinical practice. Rheumatology

HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation

(2007) Atsushi Okumura et al.   VIROLOGY