Article
Endocrinology & Metabolism
Bradley S. Miller, Joanne C. Blair, Michael Hojby Rasmussen, Aristides Maniatis, Jun Mori, Volker Boettcher, Ho-Seong Kim, Rikke Beck Bang, Michel Polak, Reiko Horikawa
Summary: This study evaluated the efficacy and tolerability of somapacitan in children with growth hormone deficiency (GHD) for 2 years and after switching from daily growth hormone treatment. The results showed that somapacitan was effective and well-tolerated during the 2-year period, and patients and caregivers preferred once-weekly somapacitan treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Aristides K. Maniatis, Samuel J. Casella, Ulhas M. Nadgir, Paul L. Hofman, Paul Saenger, Elena D. Chertock, Elena M. Aghajanova, Maria Korpal-Szczyrska, Elpis Vlachopapadopoulou, Oleg Malievskiy, Tetyana Chaychenko, Marco Cappa, Wenjie Song, Meng Mao, Per Holse Mygind, Alden R. Smith, Steven Chessler, Allison S. Komirenko, Michael Beckert, Aimee D. Shu, Paul S. Thornton
Summary: This trial aims to assess the long-term safety and efficacy of lonapegsomatropin in children with growth hormone deficiency. The results show that lonapegsomatropin treatment can continue to improve height without causing excessive advancement of bone age. Patients using the TransCon hGH Auto-Injector reported fewer local tolerability reactions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lars Savendahl, Tadej Battelino, Michael Hojby Rasmussen, Meryl Brod, Paul Saenger, Reiko Horikawa
Summary: This study evaluated the efficacy, safety, and tolerability of once-weekly somapacitan treatment for GH deficiency in children over a three-year period. The results showed sustained efficacy in height-related outcomes with similar safety and tolerability to daily GH treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Bradley S. Miller, Joanne C. Blair, Michael Hojby Rasmussen, Aristides Maniatis, Rasmus Juul Kildemoes, Jun Mori, Michel Polak, Rikke Beck Bang, Volker Boettcher, Stefano Stagi, Reiko Horikawa
Summary: Similar efficacy and safety were demonstrated for Somapacitan compared to daily GH over 52 weeks of treatment in children with GH deficiency.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Ewelina Witkowska-Sedek, Anna Malgorzata Kucharska, Malgorzata Ruminska, Monika Paluchowska, Beata Pyrzak
Summary: The study identified a significant decrease in fT4 levels in children undergoing rhGH therapy, which was observed as early as the first six months of treatment and persisted throughout. Children with greater decreases in fT4 levels were typically older, had higher bone age, and exhibited poorer responses to therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ling Hou, Ke Huang, Chunxiu Gong, Feihong Luo, Haiyan Wei, Liyang Liang, Hongwei Du, Jianping Zhang, Yan Zhong, Ruimin Chen, Xinran Chen, Jiayan Pan, Xianjiang Jin, Ting Zeng, Wei Liao, Deyun Liu, Dan Lan, Shunye Zhu, Zhiya Dong, Huamei Ma, Yu Yang, Feng Xiong, Ping Lu, Shengquan Cheng, Xuefan Gu, Runming Jin, Yu Liu, Jinzhun Wu, Xu Xu, Linqi Chen, Qin Dong, Hui Pan, Zhe Su, Lijun Liu, Xiaoming Luo, Shining Ni, Zhihong Chen, Yuhua Hu, Chunlin Wang, Jing Liu, Li Liu, Biao Lu, Xinli Wang, Yunfeng Wang, Fan Yang, Manyan Zhang, Lizhi Cao, GeLi Liu, Hui Yao, Yaqin Zhan, Mingjuan Dai, Guimei Li, Li Li, Yanjie Liu, Kan Wang, Yanfeng Xiao, Xingxing Zhang, Junhua Dong, Zaiyan Gu, Lirong Ying, Feng Huang, Yanling Liu, Zheng Liu, Jin Ye, Dongmei Zhao, Xu Hu, Zhihong Jiang, Kan Ye, Hong Zhu, Shaoke Chen, Xiaobo Chen, Naijun Wan, Zhuangjian Xu, Qingjin Yin, Hongxiao Zhang, Xiaodong Huang, Jianying Yin, Huifeng Zhang, Pin Li, Ping Yin, Junfen Fu, XiaoPing Luo
Summary: This study examined the effectiveness and safety of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric growth hormone deficiency (GHD). The results showed that PEG-rhGH had favorable outcomes and was safe for treating children with GHD. The high-dose subgroup had better treatment outcomes compared to the low-dose subgroup, and a weekly dose of 0.2 mg/kg might have additional benefits.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Oncology
Coline Puvilland, Carine Villanueva, Anaelle Hemmendinger, Laure Kornreich, Iva Gueorguieva, Melodie-Anne Karnoub, Pierre Aurelien Beuriat, Pierre Leblond
Summary: Growth hormone replacement therapy does not increase the risk of relapse in children with midline low-grade gliomas, and it is safe to use growth hormone in this population.
Article
Endocrinology & Metabolism
Cheri Deal, Joel Steelman, Elpis Vlachopapadopoulou, Renata Stawerska, Lawrence A. Silverman, Moshe Phillip, Ho-Seong Kim, Cheol Woo Ko, Oleg Malievskiy, Jose F. Cara, Carl L. Roland, Carrie Turich Taylor, Srinivas Rao Valluri, Michael P. Wajnrajch, Aleksandra Pastrak, Bradley S. Miller
Summary: This study compared the efficacy and safety of once-weekly somatrogon with once-daily somatropin in prepubertal children with growth hormone deficiency. The results showed that once-weekly somatrogon was noninferior to once-daily somatropin in terms of height velocity and change in height standard deviation score. Both treatments were well tolerated.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Margaret C. S. Boguszewski
Summary: Growth hormone deficiency is a rare but treatable cause of short stature, requiring careful evaluation of clinical history and physical examination for diagnosis. Treatment with daily growth hormone injections for many years is effective but may affect patient adherence.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Multidisciplinary Sciences
Yingying Li, Xinying Chen, Zhengduo Liu, Jinghua Yang
Summary: The systematic review and meta-analysis on the efficacy of Chinese herbal medicine (CHM) for idiopathic short stature (ISS) indicated that CHM treatment is associated with increased height, growth velocity, IGF-1 level, and growth hormone peak level, suggesting its potential effectiveness in treating ISS. Further high-quality studies are needed to confirm these conclusions due to the limited quality and quantity of current research.
Article
Multidisciplinary Sciences
Yingying Li, Xinying Chen, Zhengduo Liu, Jinghua Yang
Summary: According to the current research, Chinese herbal medicine appears to be effective for children with idiopathic short stature (ISS). More high-quality studies are needed to confirm the above conclusions due to the limited number and quality of studies included.
Article
Endocrinology & Metabolism
Aristides K. Maniatis, Ulhas Nadgir, Paul Saenger, Kent L. Reifschneider, Jennifer Abuzzahab, Larry Deeb, Larry A. Fox, Katie A. Woods, Wenjie Song, Meng Mao, Steven D. Chessler, Allison S. Komirenko, Aimee D. Shu, Samuel J. Casella, Paul S. Thornton
Summary: The phase 3 fliGHt Trial assessed the safety and tolerability of a long-acting prodrug lonapegsomatropin in children with growth hormone deficiency who switched from daily somatropin therapy. The outcomes showed that lonapegsomatropin treatment had expected results across different age groups and treatment experiences, with a similar adverse event profile to daily somatropin therapy.
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Editorial Material
Endocrinology & Metabolism
Gudmundur Johannsson, John J. Kopchick
Summary: This thematic review provides short reviews on growth hormone deficiency and insensitivity in children and adults, covering from basic science to clinical significance.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Pharmacology & Pharmacy
Chiara Mameli, Massimiliano Orso, Valeria Calcaterra, Malgorzata Gabriela Wasniewska, Tommaso Aversa, Simona Granato, Pietro Bruschini, Liliana Guadagni, Daniela d'Angela, Federico Spandonaro, Barbara Polistena, Gianvincenzo Zuccotti
Summary: This study evaluated the effectiveness, safety, adherence, quality of life, and cost-effectiveness of long-acting growth hormone (LAGH) compared to daily growth hormone (GH) in the treatment of growth hormone deficiency (GHD) in children. The results showed that all LAGH formulations were similar to daily GH in terms of efficacy, safety, adherence, and quality of life. However, more high-quality studies are needed to confirm these findings, and further research on adherence, quality of life, and cost-effectiveness is also necessary.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Silvia Ricci Bitti, Marta Franco, Manuela Albertelli, Federico Gatto, Lara Vera, Diego Ferone, Mara Boschetti
Summary: Growth hormone continues to play a role in regulating metabolism in adults and the elderly, with deficiencies leading to decreased quality of life and physical strength. GH replacement therapy may improve these conditions, but more research is needed to confirm its long-term effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Allergy
Linnea Reinert-Hartwall, Heli Siljander, Taina Harkonen, Tommi Vatanen, Jorma Ilonen, Onni Niemela, Kristiina Luopajarvi, Natalya Dorshakova, Sergei Mokurov, Aleksandr Peet, Vallo Tillmann, Raivo Uibo, Mikael Knip, Outi Vaarala, Jarno Honkanen
Summary: The study revealed that T helper cell signature cytokines are upregulated during the first 12 months of life, reflecting the natural development of adaptive immune responses; under normal circumstances, children have higher circulating levels of epidermal growth factor (EGF), which may play a protective role for children without IgE sensitization responses.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Ophthalmology
Lucinda J. Teoh, Ameenat Lola Solebo, Jugnoo S. Rahi
Summary: This study investigates the changing epidemiology of severe visual impairment (SVI) and blindness (BL) in children in the UK in the 21st century. The overall incidence rates remained stable, with higher rates in infancy. Mortality among children diagnosed in infancy declined, despite an increase in the overall proportion with non-ophthalmic impairments/disorders. The relative contribution of different groups of disorders changed over time, with an increase in cerebral visual impairment and hereditary conditions. The study highlights the increasing complexity and heterogeneity of childhood visual disability.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Endocrinology & Metabolism
Inna Starskaia, Essi Laajala, Toni Gronroos, Taina Harkonen, Sini Junttila, Roosa Kattelus, Henna Kallionpaa, Asta Laiho, Veronika Suni, Vallo Tillmann, Riikka Lund, Laura L. Elo, Harri Lahdesmaki, Mikael Knip, Ubaid Ullah Kalim, Riitta Lahesmaa
Summary: This study used RRBS technology to investigate early-stage DNA methylation changes in type 1 diabetes, identifying differentially methylated regions associated with the disease and confirming some of the results. These preliminary results provide novel insights into the cell type-specific epigenetic regulation of genes, contributing to our understanding of type 1 diabetes pathogenesis at an early stage.
Article
Endocrinology & Metabolism
Mohamad Maghnie, Michael B. Ranke, Mitchell E. Geffner, Elpis Vlachopapadopoulou, Lourdes Ibanez, Martin Carlsson, Wayne Cutfield, Raoul Rooman, Roy Gomez, Michael P. Wajnrajch, Agnes Linglart, Renata Stawerska, Peter E. Clayton, Feyza Darendeliler, Anita C. S. Hokken-Koelega, Reiko Horikawa, Toshiaki Tanaka, Helmuth Gunther Dorr, Kerstin Albertsson-Wikland, Michel Polak, Adda Grimberg
Summary: The KIGS database, which includes data from children treated with rhGH, demonstrates that rhGH is safe and effective in promoting height gain in children.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Reena Perchard, Philip George Murray, Peter Ellis Clayton
Summary: The evaluation of short children involves determining whether growth parameters are abnormal and conducting system and hormonal tests, as well as more targeted testing. Genetic analysis may be necessary for children whose diagnosis remains unclear. New genetic causes for short stature are continuously being discovered, expanding the clinical spectrum for known genes. The establishment of an international repository for short stature conditions is recommended for dissemination of knowledge and defining clinical spectrum.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Eva Mengel, Reeli Tamme, Liina Remmel, Priit Purge, Evelin Maestu, Jaak Jurimae, Vallo Tillmann
Summary: Increased insulin resistance during puberty may have a negative effect on the accumulation of lumbar spine bone mineral density independently of body composition parameters, potentially challenging adult bone quality.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Education & Educational Research
Patricia Gooding, Rebecca Crook, Melissa Westwood, Claire Faichnie, Sarah Peters
Summary: This study aims to examine the mental health and well-being of post-graduate research students over a six-month period, as well as the effects of academic pressures on depression, anxiety, and well-being. It was found that well-being significantly worsened over the six months, while levels of depression and anxiety remained relatively stable. Negative perceptions of academic challenges at baseline predicted anxiety, and social support resilience buffered the relationship between perceived academic challenges and anxiety.
STUDIES IN GRADUATE AND POSTDOCTORAL EDUCATION
(2023)
Article
Obstetrics & Gynecology
Fiskani J. M. Kondowe, Peter Clayton, Matthew Gittins, Stephen W. D'Souza, Daniel R. Brison, Stephen A. Roberts
Summary: Assessments at 6-8 weeks old and at school entry show that ART twins conceived from frozen embryo transfer (FET) grow faster than both NC twins and ART twins conceived from fresh embryo transfer (ET).
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Katie Duckett, Alice Williamson, John W. R. Kincaid, Kara Rainbow, Laura J. Corbin, Hilary C. Martin, Ruth Y. Eberhardt, Qin Qin Huang, Matthew E. Hurles, Wen He, Raja Brauner, Angela Delaney, Leo Dunkel, Romina P. Grinspon, Janet E. Hall, Joel N. Hirschhorn, Sasha R. Howard, Ana C. Latronico, Alexander A. L. Jorge, Ken McElreavey, Veronica Mericq, Paulina M. Merino, Mark R. Palmert, Lacey Plummer, Rodolfo A. Rey, Raissa C. Rezende, Stephanie B. Seminara, Kathryn Salnikov, Indraneel Banerjee, Brian Y. H. Lam, John R. B. Perry, Nicholas J. Timpson, Peter Clayton, Yee-Ming Chan, Ken K. Ong, Stephen O'Rahilly
Summary: Deleterious variants in MC3R are more frequently found in patients with constitutional delay of growth and puberty (CDGP) compared to normosmic idiopathic hypogonadotropic hypogonadism (nIHH). However, these variants are not a common cause of CDGP.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Terence Garner, Ivan Wangsaputra, Andrew Whatmore, Peter Ellis Clayton, Adam Stevens, Philip George Murray
Summary: This study demonstrates highly accurate diagnosis of childhood growth hormone deficiency using a combination of gene expression data and random forest analysis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Marit Salus, Vallo Tillmann, Liina Remmel, Eve Unt, Evelin Mäestu, Ulle Parm, Agnes Mägi, Maie Tali, Jaak Jürimäe
Summary: The aim of this study was to investigate the effects of supervised cycling sprint interval training on serum osteocalcin, lipocalin-2 and sclerostin levels, and bone mineral characteristics among obese adolescent boys. After a 12-week intervention, there were significant improvements in bone mineral content and density in the SIT group. However, no significant differences were found in osteocalcin, lipocalin-2, and sclerostin levels between the two groups.
Article
Environmental Sciences
Daniel M. Ripley, Terence Garner, Samantha A. Hook, Ana Verissimo, Bianka Grunow, Timo Moritz, Peter Clayton, Holly A. Shiels, Adam Stevens
Summary: Exposure to elevated temperatures during embryogenesis can alter the transcriptomic organization in later life, increasing the entropy of gene interaction networks and potentially impacting an individual's responsiveness to future temperature challenges.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Meeting Abstract
Endocrinology & Metabolism
Mari Lukka, Vallo Tillmann, Aleksandr Peet
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Eva Mengel, Reeli Tamme, Liina Remmel, Priit Purge, Evelin Maestu, Jaak Jurimae, Vallo Tillmann
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Reeli Tamme, Jaak Jurimae, Evelin Maestu, Liina Remmel, Priit Purge, Eva Mengel, Vallo Tillmann
Summary: The study found a negative association between leptin to adiponectin ratio (LAR) in puberty and lumbar spine bone mineral density (BMD) and bone mineral apparent density (BMAD) at the age of 18.