Journal
JOURNAL OF NEUROCHEMISTRY
Volume 129, Issue 4, Pages 683-695Publisher
WILEY
DOI: 10.1111/jnc.12661
Keywords
acidification; cAMP; interleukin-1; microglia; protein kinase A; TDAG8
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Funding
- Japan Society for the Promotion of Science [21390016, 24500435]
- Global COE Program from the Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Japan-Korea basic scientific cooperation program
- Grants-in-Aid for Scientific Research [24500435, 21390016, 23591916, 25670617, 25116703] Funding Source: KAKEN
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A number of studies have shown that extracellular acidification in brain is observed in ischemia and neurodegenerative disorders. However, the molecular mechanism by which extracellular acidification regulates the biological activities of microglia remains uncharacterized. Here, we examined the extracellular acidic pH regulation of IL-1 production, especially focusing on TDAG8, a member of OGR1 family receptors. Our results suggest that extracellular acidic pH inhibited lipopolysaccharide -induced IL-1 production at least partly through the TDAG8/cAMP pathway, by inhibiting ERK and JNK activities.
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