Journal
JOURNAL OF NEUROCHEMISTRY
Volume 129, Issue 4, Pages 743-752Publisher
WILEY-BLACKWELL
DOI: 10.1111/jnc.12657
Keywords
cerebellar granule neurons; dendrite; NMDA receptor; phosphorylation; PP1; PP2A; transcription factor Sp4
Categories
Funding
- NIH [RO1 HD043364]
- NIH NINDS [T32 NS061764]
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We show that the neuronal transcription factor Sp4, which regulates the developmental patterning of dendrites, is dephosphorylated at S770 in response to NMDA receptor signaling in cerebellar granule neurons and cortical neurons. Dephosphorylation required the activity of the PP1/PP2A phosphatase. A point mutation at S770 to a phosphomimetic aspartic acid residue impaired Sp4-dependent pruning of cerebellar granule neuron primary dendrites.
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