Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

(2012) Christian A. von Hehn et al.   NEURON

Spinal P2X7 receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model

(2011) Wen-Juan He et al.   BEHAVIOURAL BRAIN RESEARCH

Neuronal Fc-gamma receptor I mediated excitatory effects of IgG immune complex on rat dorsal root ganglion neurons

(2011) Lintao Qu et al.   BRAIN BEHAVIOR AND IMMUNITY

Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain

(2011) Peter M. Grace et al.   BRAIN BEHAVIOR AND IMMUNITY

Antibody - Fc receptor interactions in protection against intracellular pathogens

(2011) Nicole Joller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhanced Angiotensin II type 1 receptor expression in leukocytes of patients with chronic kidney disease

(2011) Helena Chon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects

(2011) Alice De Corato et al.   JOURNAL OF NEUROIMMUNOLOGY

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Pain-Related Increase of Excitatory Transmission and Decrease of Inhibitory Transmission in the Central Nucleus of the Amygdala are Mediated by mGluR1

(2011) Wenjie Ren et al.   Molecular Pain

Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction

(2011) Jeffrey S Mogil et al.   NATURE NEUROSCIENCE

Emerging molecular biomarkers—blood-based strategies to detect and monitor cancer

(2011) Samir M. Hanash et al.   Nature Reviews Clinical Oncology

Robert Dworkin

(2011)   NATURE REVIEWS DRUG DISCOVERY

Noradrenergic regulation of period1 expression in spinal astrocytes is involved in protein kinase A, c-Jun N-terminal kinase and extracellular signal-regulated kinase activation mediated by α1- and β2-adrenoceptors

(2011) T. Sugimoto et al.   NEUROSCIENCE

Changes in calcineurin message, enzyme activity and protein content in the spinal dorsal horn are associated with chronic constriction injury of the rat sciatic nerve

(2011) G. Miletic et al.   NEUROSCIENCE

Patterns of pain: Meta-analysis of microarray studies of pain

(2011) Michael L. LaCroix-Fralish et al.   PAIN

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN

Osteoprotegerin: A Biomarker With Many Faces

(2010) Kenneth Caidahl et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer's Disease

(2010) Benoit Melchior et al.   ASN Neuro

Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain

(2010) Peter M. Grace et al.   BRAIN BEHAVIOR AND IMMUNITY

Stimulation of β2-adrenergic receptors inhibits calcineurin activity in CD4+ T cells via PKA–AKAP interaction

(2010) Carsten Riether et al.   BRAIN BEHAVIOR AND IMMUNITY

CXCR4 signaling mediates morphine-induced tactile hyperalgesia

(2010) Natalie M. Wilson et al.   BRAIN BEHAVIOR AND IMMUNITY

Angiotensin II Type 1 receptor (AT1) signaling in astrocytes regulates synaptic degeneration-induced leukocyte entry to the central nervous system

(2010) L. Füchtbauer et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)

(2010) Tyler R Simpson et al.   CURRENT OPINION IN IMMUNOLOGY

A novel role of prostaglandin E2 in neuropathic pain

(2010) Shunji Kunori et al.   GLIA

Tmem176B and Tmem176A are associated with the immature state of dendritic cells

(2010) Thomas Condamine et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

(2010) Paul J. Austin et al.   JOURNAL OF NEUROIMMUNOLOGY

A novel animal model of graded neuropathic pain: Utility to investigate mechanisms of population heterogeneity

(2010) Peter M. Grace et al.   JOURNAL OF NEUROSCIENCE METHODS

Nociceptor sensitization in pain pathogenesis

(2010) Michael S Gold et al.   NATURE MEDICINE

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Fcγ receptors contribute to pyramidal cell death in the mouse hippocampus following local kainic acid injection

(2010) S. Suemitsu et al.   NEUROSCIENCE

Preliminary Study of the Plasma and Cerebrospinal Fluid Concentrations of IL-6 and IL-10 in Patients with Chronic Pain Receiving Intrathecal Opioid Infusions by Chronically Implanted Pump for Pain Management

(2010) Che S. Zin et al.   PAIN MEDICINE

Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

(2010) M. Kronlage et al.   Science Signaling

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Blockade of murine T cell activation by antagonists of P2Y6 and P2X7 receptors

(2009) Mitsutoshi Tsukimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

C1q enhances IFN-  production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells

(2009) P. Baruah et al.   BLOOD

Heat shock protein 27 upregulation and phosphorylation in rat experimental autoimmune encephalomyelitis

(2009) Heechul Kim et al.   BRAIN RESEARCH

The Value, Qualification, and Regulatory Use of Surrogate End Points in Drug Development

(2009) CD Lathia et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Chutes and Ladders on the Critical Path:Comparative Effectiveness, Product Value, and the Use of Biomarkers in Drug Development

(2009) J Woodcock   CLINICAL PHARMACOLOGY & THERAPEUTICS

Microvascular Reactivity and Inflammatory Cytokines in Painful and Painless Peripheral Diabetic Neuropathy

(2009) John Doupis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in central nervous system inflammation

(2009) Olaf Hoffmann et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Differential gene expression in LPS/IFNγ activated microglia and macrophages:in vitroversusin vivo

(2009) Christoph D. Schmid et al.   JOURNAL OF NEUROCHEMISTRY

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

(2009) M. Costigan et al.   JOURNAL OF NEUROSCIENCE

Differential Functions of Interferon-Upregulated Sp100 Isoforms: Herpes Simplex Virus Type 1 Promoter-Based Immediate-Early Gene Suppression and PML Protection from ICP0-Mediated Degradation

(2009) D. G. Negorev et al.   JOURNAL OF VIROLOGY

Correlational Analysis for Identifying Genes whose Regulation Contributes to Chronic Neuropathic Pain

(2009) Anna-Karin Persson et al.   Molecular Pain

Differential Regulation of Immune Responses and Macrophage/Neuron Interactions in the Dorsal Root Ganglion in Young and Adult Rats following Nerve Injury

(2009) David Vega-Avelaira et al.   Molecular Pain

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Neuronal and glial cell expression of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in the rat retina

(2009) L.E. Downie et al.   NEUROSCIENCE

DIFFERENTIAL CONTRIBUTION OF β-ADRENERGIC RECEPTORS EXPRESSED ON RADIOSENSITIVE VERSUS RADIORESISTANT CELLS TO PROTECTION AGAINST INFLAMMATION AND MORTALITY IN MURINE ENDOTOXEMIA

(2009) Jill Walker-Brown et al.   SHOCK

IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation

(2008) Yasutaka Okabe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glia in pathological pain: A role for fractalkine

(2008) E.D. Milligan et al.   JOURNAL OF NEUROIMMUNOLOGY

TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation

(2008) Mude Shi et al.   NATURE IMMUNOLOGY

The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain

(2008) L. Cao et al.   NEUROSCIENCE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Identifying biological markers of activity in human nociceptive pathways to facilitate analgesic drug development

(2008) Boris A. Chizh et al.   PAIN

Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2

(2008) Sacha A. Malin et al.   PAIN

Pain Genes

(2008) Tom Foulkes et al.   PLoS Genetics

The Adenosine A2b Receptor: Its Role in Inflammation

(2008) J. Ham et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Activation of the nuclear factor of activated T-cells (NFAT) mediates upregulation of CCR2 chemokine receptors in dorsal root ganglion (DRG) neurons: A possible mechanism for activity-dependent transcription in DRG neurons in association with neuropathic pain

(2007) Hosung Jung et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Selective stimulation of GalR1 and GalR2 in rat substantia gelatinosa reveals a cellular basis for the anti- and pro-nociceptive actions of galanin

(2007) Kwai A. Alier et al.   PAIN

Prevalence of chronic pain with neuropathic characteristics in the general population

(2007) Didier Bouhassira et al.   PAIN

Group I mGlu receptor stimulation inhibits activation-induced cell death of human T lymphocytes

(2006) Annalisa Chiocchetti et al.   BRITISH JOURNAL OF PHARMACOLOGY