A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

(2011) Darragh B. Freir et al.   Nature Communications

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

Blood-Borne Amyloid-  Dimer Correlates with Clinical Markers of Alzheimer's Disease

(2010) V. L. Villemagne et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils

(2010) B. O'Nuallain et al.   JOURNAL OF NEUROSCIENCE

Generation and Therapeutic Efficacy of Highly Oligomer-Specific  -Amyloid Antibodies

(2010) H. Hillen et al.   JOURNAL OF NEUROSCIENCE

Testing the amyloid hypothesis of Alzheimer's disease in vivo

(2010) Sam Gandy   LANCET NEUROLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stabilization of neurotoxic Alzheimer amyloid-  oligomers by protein engineering

(2010) A. Sandberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

(2009) W. Mei Kok et al.   CHEMICAL COMMUNICATIONS

Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

(2009) Akihiko Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inherent Anti-amyloidogenic Activity of Human Immunoglobulin γ Heavy Chains

(2009) Sharad P. Adekar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: synaptic dysfunction and Aβ

(2009) Ganesh M Shankar et al.   Molecular Neurodegeneration

Human Plasma Contains Cross-Reactive Aβ Conformer-Specific IgG Antibodies†

(2008) Brian O’Nuallain et al.   BIOCHEMISTRY

Soluble amyloid-  peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo

(2008) N.-W. Hu et al.   BRAIN

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Single-domain antibodies recognize selectively small oligomeric forms of amyloid β, prevent Aβ-induced neurotoxicity and inhibit fibril formation

(2008) Pierre Lafaye et al.   MOLECULAR IMMUNOLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Vaccination with soluble Aβ oligomers generates toxicity-neutralizing antibodies

(2003) Mary P. Lambert et al.   JOURNAL OF NEUROCHEMISTRY