Review
Biochemistry & Molecular Biology
Danail Minchev, Maria Kazakova, Victoria Sarafian
Summary: Parkinson's disease is a neurodegenerative disorder characterized by neuronal degeneration and the accumulation of alpha-Synuclein aggregates. Neuroinflammation and autophagy are crucial processes implicated in the development of Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Luying Qiu, Yaxuan Wang, Yuye Wang, Fang Liu, Shumin Deng, Weishuang Xue, Yanzhe Wang
Summary: This study used the OGDR model to evaluate ischemic stroke and cerebral ischemia-reperfusion (I/R) injury in vitro. It found that excessively activated microglia can cause neuronal damage by producing pro-inflammatory mediators. The study demonstrated that UA can reduce neuronal damage by reversing the MMP/TIMP imbalance caused by microglia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Sanja Dimic-Janjic, Mir Alireza Hoda, Branislava Milenkovic, Jelena Kotur-Stevuljevic, Mihailo Stjepanovic, Daniela Gompelmann, Jelena Jankovic, Milica Miljkovic, Jelena Milin-Lazovic, Natasa Djurdjevic, Dragana Maric, Ivan Milivojevic, Spasoje Popevic
Summary: Serum levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) are elevated in patients with chronic obstructive pulmonary disease (COPD), indicating an imbalance between proteases and protease inhibitors. MMP-9 and MMP-9/TIMP-1 ratio are associated with lung function, symptom severity scores, and acute exacerbations.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Clinical Neurology
Kevin Connolly, Mikael Lehoux, Ryan O'Rourke, Benedetta Assetta, Guzide Ayse Erdemir, Jack A. Elias, Chun Geun Lee, Yu-Wen Alvin Huang
Summary: CHI3L1 is a biomarker for early detection of neuroinflammation and disease diagnosis of AD. It is primarily provided by astrocytes in the brain and may play a crucial role in neuroinflammation and neurodegenerative diseases. In peripheral tissues, it is also a master regulator for injury and repair events.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Madiha Rasheed, Junhan Liang, Chaolei Wang, Yulin Deng, Zixuan Chen
Summary: Neuroinflammation plays a significant role in the initiation and progression of Parkinson's disease, activating the neuronal immune system and triggering a vicious cycle of inflammation-induced dopaminergic neuron damage. Epigenetic mechanisms are at the forefront of regulating neuroinflammatory factors, offering potential for breaking this cycle. These mechanisms do not work independently but cooperatively, impacting various neuroinflammatory pathways and potentially influencing PD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Arash Heidari, Niloufar Yazdanpanah, Nima Rezaei
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and aggregation of alpha-synuclein. Recent studies suggest that neuroinflammation may contribute to the loss of dopaminergic neurons in PD.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Biochemistry & Molecular Biology
Ahsas Goyal, Aanchal Verma, Anant Agrawal, Nandini Dubey, Abhay Kumar, Tapan Behl
Summary: Parkinson's disease is a common neurodegenerative illness with limited treatment options. It is caused by various pathological events and can worsen with aging population. Crocin, a natural compound, has shown considerable neuroprotective benefits and is considered a safe and effective therapeutic choice for Parkinson's disease.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Medicine, Research & Experimental
Xue Li, Ruijun Deng, Jie Li, Hui Li, Zhe Xu, Lei Zhang, Linyin Feng, Chunying Shu, Mingming Zhen, Chunru Wang
Summary: The study explores the therapeutic potential of oral fullerene for Parkinson's disease (PD) by reducing neuroinflammation through modulating gut microbiome diversity and increasing short chain fatty acids content. This approach effectively prevents dopaminergic neuronal degeneration, significantly improves motor deficits, and reverses dopamine loss in PD mice, demonstrating low toxicity and promising prospects for clinical treatment.
Review
Immunology
Martin Regensburger, Shafqat Rasul Chaudhry, Hammad Yasin, Yining Zhao, Andreas Stadlbauer, Michael Buchfelder, Thomas Kinfe
Summary: An increasing body of experimental evidence suggests a link between immunometabolic deterioration and the progression of Parkinson's disease. In particular, the dysregulation of central and peripheral neuroinflammatory networks mediated by circulating adipokines, such as leptin, may play a role. This article summarizes the existing evidence on the role of adipokines in Parkinson's disease and discusses their potential as therapeutic targets.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Orthopedics
Bohui Shi, Xiong Guo, Aili Iv, Zengtie Zhang, Xiaowei Shi
Summary: This study found that MMP-3 is associated with the susceptibility of KBD, and the imbalance expression of MMPs / TIMPs may play an important role in cartilage degradation and osteoarthritis formation in both KBD and OA.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Yumin Wang, Shuang Wu, Qiang Li, Weihong Lang, Wenjing Li, Xiaodong Jiang, Zhirong Wan, Jichao Chen, Hongquan Wang
Summary: This review summarizes the recent updates and knowledge of the molecular mechanisms underlying the neuroprotective effects of epigallocatechin 3-gallate (EGCG) derived from green tea extract in Parkinson's disease (PD). The review highlights the pleiotropic effects of EGCG, including anti-apoptotic, anti-oxidative stress, anti-inflammatory, modulation of dopamine production, and inhibition of alpha-synuclein aggregation, which make it a promising neuroprotective compound for the treatment of PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ritu Soni, Prashant Delvadia, Amit Joharapurkar, Jigna Shah
Summary: Parkinson's disease (PD) is a common progressive disorder characterized by deposition of inclusion bodies on dopaminergic neurons in the brain. The major component of these inclusion bodies is α-synuclein aggregates, which gradually propagate PD pathology. Underexplored molecular targets could potentially aid in the development of novel therapeutics for PD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Clinical Neurology
Guy C. Brown, Marta Camacho, Caroline H. Williams-Gray
Summary: The endotoxin hypothesis suggests that lipopolysaccharide (LPS) endotoxins contribute to the pathogenesis of Parkinson's disease through gut dysfunction, elevated LPS levels, inflammation, and neurodegeneration. Evidence supporting this hypothesis includes early gut dysfunction, increased LPS levels in some PD patients, and the ability of LPS to induce alpha-synuclein expression and neurotoxicity.
MOVEMENT DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Katja Badanjak, Sonja Fixemer, Semra Smajic, Alexander Skupin, Anne Gruenewald
Summary: With the aging population, the incidence of Parkinson's disease is increasing, with inflammatory processes playing a major role in its pathology. Microglia have been shown to have a significant neuroprotective role in PD, and the progression of PD may be driven by a vicious cycle between dying neurons and microglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Rana E. Kamal, Esther Menze, Amgad Albohy, Hebatalla I. Ahmed, Samar S. Azab
Summary: This study evaluated the potential of carvedilol as an anti-Parkinson's drug and anti-tau protein target through computational simulation and in vivo experiments. The results suggest that carvedilol has neuro-protective effects and may be a candidate for the management of Parkinson's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)