Article
Multidisciplinary Sciences
Joshua Orvis, Caroline B. Albertin, Pragya Shrestha, Shuangshuang Chen, Melanie Zheng, Cheyenne J. Rodriguez, Luke J. Tallon, Anup Mahurkar, Aleksey Zimin, Michelle Kim, Kelvin Liu, Eric R. Kandel, Claire M. Fraser, Wayne Sossin, Thomas W. Abrams
Summary: The gastropod mollusk Aplysia is an important model organism used in cellular and molecular neurobiological studies. By studying the improved transcriptome of the Aplysia nervous system, researchers can explore the evolution of cognitive capacity at the molecular level. Comparing Aplysia with the octopus, it was found that both have a similar complement of genes linked to neuronal function, but vertebrates have more isoforms of certain scaffold proteins. This analysis provides insights into the evolution of the synaptic proteome and suggests that synaptic proteins and plasticity evolved gradually.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Ning Liu, Shiqiang Sun, Pengjie Wang, Yanan Sun, Qingjuan Hu, Xiaoyu Wang
Summary: Serotonin, also known as 5-hydroxytryptamine (5-HT), is a crucial neurotransmitter synthesized and secreted by enterochromaffin (EC) cells in the gastrointestinal tract. Gut microbiota, nutrients, and hormones play key roles in regulating 5-HT secretion. Understanding the regulatory mechanisms of 5-HT in the immune system can potentially provide therapeutic strategies for treating intestinal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Jianzhi Zeng, Xuelin Li, Renzimo Zhang, Mingyue Lv, Yipan Wang, Ke Tan, Xiju Xia, Jinxia Wan, Miao Jing, Xiuning Zhang, Yu Li, Yang Yang, Liang Wang, Jun Chu, Yan Li, Yulong Li
Summary: This study found that dopamine bi-directionally regulates the temporal window of olfactory learning in Drosophila and affects the synaptic plasticity of Kenyon cells in the mushroom body. The release of acetylcholine by KCs activates the serotonergic DPM neuron, which provides inhibitory feedback to KCs. The study also discovered that 5-HT signals have spatial heterogeneity in the mushroom body and can proportionally gate the coincidence time windows of different compartments.
Article
Multidisciplinary Sciences
Maxemiliano V. Vargas, Lee E. Dunlap, Chunyang Dong, Samuel J. Carter, Robert J. Tombari, Shekib A. Jami, Lindsay P. Cameron, Seona D. Patel, Joseph J. Hennessey, Hannah N. Saeger, John D. McCorvy, John A. Gray, Lin Tian, David E. Olson
Summary: Decreased dendritic spine density in the cortex is a common feature of neuropsychiatric diseases, and psychedelics have been found to promote cortical neuron growth. This study shows that intracellular 5-HT2A receptors mediate the plasticity-promoting effects of psychedelics, providing insight into the mechanisms behind their therapeutic effects. The findings suggest that targeting intracellular 5-HT2A receptors could be a potential therapeutic approach.
Review
Biochemistry & Molecular Biology
Candice M. Roux, Marianne Leger, Thomas Freret
Summary: The hippocampus plays a crucial role in memory disorders, with 5-HT(4)Rs receptors emerging as potential new therapeutic targets. Activation of 5-HT(4)Rs may help in restoring or limiting hippocampal alterations associated with neurological diseases, though further research is needed to fully understand the mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Rashid Giniatullin
Summary: 5-hydroxytryptamine (5-HT) is considered a key mediator in migraine, but the role of 5-HT3 receptors in pain transmission remains controversial. The applicability of currently available 5-HT3 antagonists in migraine treatment is not clearly supported by clinical data.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuan Tu, Shengping Yao, Qiong Chen, Wenqin Li, Yinghui Song, Pei Zhang
Summary: 5-HT signaling plays a crucial role in the development of non-small cell lung cancer (NSCLC), and inhibitors of 5-HT uptake have potential therapeutic value in the treatment of NSCLC patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Biochemistry & Molecular Biology
Jing Yi Zheng, Ting Kang, Chao Jiang, Li Ke Lin, Lu Gao, Li Hua Jin, Yu Shu, Jing Jing Zhang, Cong Li, Bang Chen, Ye Hua Shen
Summary: Walnut oil improves cognitive impairment by influencing the secretion of neurotransmitters through the regulation of gut microbiota.
Article
Biochemistry & Molecular Biology
Jing Yi Zheng, Ting Kang, Chao Jiang, Li Ke Lin, Lu Gao, Li Hua Jin, Yu Shu, Jing Jing Zhang, Cong Li, Bang Chen, Ye Hua Shen
Summary: Walnut oil supplementation can improve cognitive impairment by influencing the secretion of neurotransmitters through the regulation of gut microbiota.
Article
Cell Biology
Anurag Pandey, Neil Hardingham, Kevin Fox
Summary: This study explores the synaptic plasticity properties of RS and IB cells in the mouse visual cortex during the critical period for ocular dominance plasticity. It reveals that RS neurons show synaptic depression in response to both dark exposure and monocular deprivation, while IB cells exhibit opposite responses. The potentiation in IB cells depends on CaMKII-autophosphorylation, while RS cells mature during the critical period.
Article
Neurosciences
Federica Campanelli, Gioia Marino, Noemi Barsotti, Giuseppina Natale, Valeria Calabrese, Antonella Cardinale, Veronica Ghiglieri, Giacomo Maddaloni, Alessandro Usiello, Paolo Calabresi, Massimo Pasqualetti, Barbara Picconi
Summary: The study reveals that sex-specific neural modulation may result in abnormalities in corticostriatal plasticity in mice. Furthermore, the interaction between dopaminergic and serotonergic systems plays a crucial role in controlling striatal synaptic plasticity.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Cell Biology
Supriya Swarnkar, Yosef Avchalumov, Isabel Espadas, Eddie Grinman, Xin-An Liu, Bindu L. Raveendra, Aya Zucca, Sonia Mediouni, Abhishek Sadhu, Susana Valente, Damon Page, Kyle Miller, Sathyanarayanan Puthanveettil
Summary: The study reveals the roles of KIF5C and KIF3A in synaptic structural plasticity and memory storage. KIF5C is a key component of local translation, associated with numerous RNAs, and its loss of function affects spatial and contextual fear memory.
Article
Behavioral Sciences
Guoyi Tang, Yuan Guo, Li Zhang, Tao Wang, Ruotong Li, Jie Yang, Yixuan Wang, Jian Liu
Summary: This study found that the BLA's 5-HT1B receptors regulate anxiety-like behavior, but the effects on PD-related anxiety are unclear. The results showed that the 5-HT1B receptor agonist induced anxiety-like effects, while the antagonist produced anxiolytic-like responses. Further investigation revealed the involvement of the AC-PKA signaling pathway in this process.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Christine L. West, Karen-Anne Mcvey Neufeld, Yu-Kang Mao, Andrew M. Stanisz, Paul Forsythe, John Bienenstock, Denise Barbut, Michael Zasloff, Wolfgang A. Kunze
Summary: The vagus nerve plays a crucial role in relaying mood-altering signals from the gut to the brain, affecting the behavioral effects of both antidepressants and prodepressants in mice. Through ex vivo experiments, it was found that single vagal fibers have a unique neural firing pattern code in response to vagus-dependent antidepressant stimuli, whether from chemicals or bacteria.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Yujie Xiao, Haozhe Chen, Liang Nie, Meina He, Qi Peng, Wenjing Zhu, Hailing Nie, Wenli Chen, Qiaoyun Huang
Summary: The study found that c-di-GMP/FleQ can promote the plankton-to-biofilm lifestyle transition of Pseudomonas species at the transcriptional level and identified new target genes directly regulated by c-di-GMP/FleQ. Additionally, it revealed the role of c-di-GMP/FleQ in LapA secretion and cAMP synthesis regulation.
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)