Article
Chemistry, Inorganic & Nuclear
Arpan Bera, Srishti Gautam, Md Kausar Raza, Apurba Kumar Pal, Paturu Kondaiah, Akhil R. Chakravarty
Summary: This study investigates the synthesis, characterization, and in vitro cytotoxicity of dipicolylamine (dpa) based platinum(ii) complexes. The results demonstrate that these complexes exhibit strong photodynamic therapy (PDT) activity and low chemotherapy activity, inducing apoptosis under red light irradiation and forming adducts with DNA. The complexes preferentially localize in mitochondria and endoplasmic reticulum. These findings provide insights for the development of novel PDT agents.
DALTON TRANSACTIONS
(2022)
Article
Polymer Science
Milena B. Boarini, Natalia S. Gsponer, Maria E. Milanesio, Edgardo N. Durantini
Summary: This study synthesized two novel polymeric conjugates that exhibited significant photodynamic effects and tested their photoinactivation abilities against Staphylococcus aureus and Escherichia coli.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Chemistry, Inorganic & Nuclear
Christopher C. Rennie, Robert M. Edkins
Summary: Phototherapy, using light to selectively ablate cancerous tissue, shows promising prospects. The use of Pc-drug conjugates as targeted anticancer phototherapeutic systems has shown potential in improving treatment specificity and achieving precise, synergistic phototherapy.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Ching-Hua Tsai, Tai-Yu Chiu, Chiung-Tong Chen, Chia-Yu Hsu, Ya-Ru Tsai, Teng-Kuang Yeh, Kuan-Hsun Huang, Lun Kelvin Tsou
Summary: In this study, an efficient Ugi multicomponent reaction and click chemistry approach were used to synthesize a series of bioactive zinc(II) dipicolylamine (ZnDPA)-based SN-38 conjugates. Comparative studies were conducted to identify a potent ZnDPA-based conjugate for pancreatic cancer treatment, which showed an 80% reduction in cytotoxic payload compared to the marketed drug irinotecan.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Irene Paramio, Ainhoa Salazar, Mireia Jorda-Redondo, Santi Nonell, Tomas Torres, Gema de la Torre
Summary: In this study, the authors demonstrated the ability of amphiphilic Phthalocyanine (Pc) photosensitizers (PS) to assemble into cationic nanoparticles in water and effectively kill bacterial strains through photoinactivation. The stability and characteristics of the PS nanoparticles were investigated using various spectroscopic and imaging techniques. Among the synthesized PS, PS1 showed the highest efficacy in killing both gram-positive S. aureus and gram-negative E. coli, potentially due to its lower stability and ability to recover the photophysical properties of the non-aggregated species after binding to the bacteria surface.
ADVANCED THERAPEUTICS
(2023)
Article
Chemistry, Physical
Aoibhin A. Cullen, Ashwene Rajagopal, Katharina Heintz, Andreas Heise, Robert Murphy, Igor Sazanovich, Gregory M. Greetham, Michael Towrie, Conor Long, Deirdre Fitzgerald-Hughes, Mary T. Pryce
Summary: This study reports a neutral BODIPY photosensitizing copolymer with enhanced absorption towards the red and a quantum yield of 0.34 for singlet oxygen generation. The steps leading to the population of the triplet state were studied using time-resolved spectroscopic techniques, showing potential broad-spectrum antimicrobial activity under visible light exposure.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Ana F. Amendoeira, Andre Luz, Ruben Valente, Catarina Roma-Rodrigues, Hasrat Ali, Johan E. van Lier, Fernanda Marques, Pedro V. Baptista, Alexandra R. Fernandes
Summary: This study evaluated the cell uptake of Estradiol-BODIPY, 19-nortestosterone-BODIPY, and testosterone-BODIPY in breast cancer and prostate cancer cells, as well as in normal dermal fibroblasts. The results showed that the highest internalization occurred in cells expressing specific receptors for the compounds. Blocking experiments also revealed differences in non-specific cell uptake between cancer and normal cells, possibly due to differences in lipophilicity. The internalization process was energy-dependent and mediated by clathrin- and caveolae-endocytosis. Co-culture studies demonstrated that the compounds exhibited selectivity towards cancer cells. Furthermore, the compounds showed non-toxicity towards cancer and/or normal cells, and visible light irradiation induced cell death, indicating their potential use as PDT agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Isabel Wen Badon, Jun-Pil Jee, Temmy Pegarro Vales, Chanwoo Kim, Seungbin Lee, Jaesung Yang, Si Kyung Yang, Ho-Joong Kim
Summary: The straightforward synthesis of three cationic boron-dipyrromethene (BODIPY) derivatives and their mitochondria-targeting and photodynamic therapeutic (PDT) capabilities are reported. The halogenated BODIPY dyes exhibit lower fluorescence quantum yields and enable the efficient production of singlet oxygen species. The synthesized dyes displayed good PDT capabilities against cancer cell lines, with low cytotoxicity in the dark, demonstrating the potential of cationic BODIPY-based dyes as therapeutic drugs for anticancer photodynamic therapy.
Article
Chemistry, Applied
Serdal Kaya, Yahya A. Ismaiel, Nahyun Kwon, Gyoungmi Kim, Jose L. Bila, Juyoung Yoon, Ozlem Seven, Engin U. Akkaya
Summary: Singlet oxygen is a cytotoxic reactive species involved in cancer photodynamic therapy. Bodipy-based fluorescent dyes with singlet oxygen reactive modules can signal the intracellular generation of singlet oxygen through photosensitization. Long wavelength probes of singlet oxygen based on this approach are expected to be highly valuable.
Article
Nanoscience & Nanotechnology
Bruno L. Raposo, Sueden Souza, Gleyciane S. Santana, Max T. A. Lima, Jose F. Sarmento-Neto, Julio S. Reboucas, Goreti Pereira, Beate S. Santos, Paulo E. Cabral Filho, Martha S. Ribeiro, Adriana Fontes
Summary: Researchers proposed a novel method of using polyvinylpyrro-lidone (PVP) coated silver nanoparticles (AgNPs) in combination with cationic Zn(II) porphyrins (ZnPs) for photodynamic inactivation (PDI) of Candida albicans infections. The AgNPs-ZnPs system achieved complete eradication of Candida albicans at lower porphyrin concentrations, reducing the risk of antifungal drug resistance.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biophysics
Xiaohong Ruan, Min Wei, Xiaoyu He, Leichen Wang, Dongliang Yang, Yu Cai, Jinjun Shao, Xiaochen Dong
Summary: In this study, an aza-BODIPY-derived photosensitizer NBDP was designed and synthesized for synergistic photothermal therapy (PTT) and photodynamic therapy (PDT). NBDP showed good singlet oxygen generation capacity and high photothermal conversion efficiency. Additionally, NBDP NPs were found to target tumor tissues guided by in vivo photoacoustic imaging. These results suggest the potential of NBDP for PA/photothermal imaging-guided synergistic PTT/PDT.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Diego Navarro-Barreda, Rosa de Llanos, Juan F. Miravet, Francisco Galindo
Summary: Two new brominated BODIPYs containing amino acid-based chains were synthesized and characterized. These compounds showed efficient generation of singlet oxygen in organic solvents but not in aqueous media. However, both compounds exhibited positive antimicrobial activity against gram-positive and gram-negative bacteria. The higher efficiency of compound 2 can be attributed to the presence of a protonatable residue, allowing more effective interaction with the cell walls of microorganisms.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Chemistry, Applied
Muhammad Amir Masood, Yanping Wu, Yuncong Chen, Hao Yuan, Naila Sher, Faisal Faiz, Shankun Yao, Fen Qi, M. Irfan Khan, Mushtaq Ahmed, Nadia Mushtaq, Weijiang He, Zijian Guo
Summary: Cancer initiation and propagation are closely related to bacterial infection, necessitating the simultaneous use of anticancer drugs and antibiotics. To address this, two BODIPY-based cationic photosensitizers, 1BDPC-Py and 1BDPC-TPP, were developed for treating both cancer and bacterial infection. These photosensitizers showed excellent therapeutic effects, high phototoxicity, and promising photodynamic activity against cancer cells and bacterial species.
Article
Biochemistry & Molecular Biology
Mengran Wang, Kedan Gu, Miyang Wan, Lu Gan, Jingtao Chen, Weili Zhao, Hang Shi, Jiyang Li
Summary: This study evaluated the synergistic effect of a new BODIPY derivative and hydrogen peroxide on combating Candida albicans infections. The combination of BDP-4L and H2O2 showed enhanced photokilling efficacy against the yeast. The addition of H2O2 significantly increased the effectiveness of PDI in reducing C. albicans biofilms.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)
Article
Infectious Diseases
Sofia C. Santamarina, Daniel A. Heredia, Andres M. Durantini, Edgardo N. Durantini
Summary: The widespread use of antibiotics has led to an increase in microbial resistance, necessitating the development of new strategies to combat pathogens. Photoactive polymers offer an interesting approach to kill microbes and maintain aseptic surfaces.