Journal
JOURNAL OF NEUROCHEMISTRY
Volume 108, Issue 5, Pages 1300-1308Publisher
WILEY
DOI: 10.1111/j.1471-4159.2009.05880.x
Keywords
hippocampus; inorganic; neocortex; phosphate; precipitation; zinc
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Funding
- NINDS [NS47508]
- NIEHS through the University of Iowa Environmental Health Sciences Research Center
- NIEHS/NIH [P30 ES0560]
- Center for Biocatalysis Bioprocessing
- NSF [CHE 0320387]
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Inorganic phosphate (Pi) is an important polyanion needed for ATP synthesis and bone formation. As it is found at millimolar levels in plasma, it is usually incorporated as a constituent of artificial CSF formulations for maintaining brain slices. In this paper, we show that Pi limits the extracellular zinc concentration by inducing metal precipitation. We present data suggesting that amino acids like histidine may counteract the Pi-induced zinc precipitation by the formation of soluble zinc complexes. We propose that the interplay between Pi and amino acids in the extracellular space may influence the availability of metals for cellular uptake.
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