Article
Biochemistry & Molecular Biology
Xiaokun Zhou, Danping Lu, Wenxiang Yi, Dan Xu
Summary: The study investigated the role of CDC25C in neural progenitor cell division and differentiation by knocking down the gene in developing rat brains. The results showed that CDC25C is essential for maintaining the proliferative state of neural progenitor cells during cortical development. Knockdown of CDC25C resulted in early cell cycle exit and premature differentiation of neural progenitor cells, revealing a novel role for CDC25C in NPC division and cell fate determination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Cheng-Yi Chang, Chih-Cheng Wu, Jiaan-Der Wang, Jian-Ri Li, Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Su-Lan Liao, Chun-Jung Chen
Summary: The study demonstrated that DHA exhibits anti-inflammatory, neuroprotective, and antiviral effects against JEV infection by modulating the immune response of microglia and neurons. This suggests that DHA may be a potential candidate for treating neuroinflammation associated with viral infections such as Japanese Encephalitis.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Cell Biology
Huimin Zhao, Jie Wei, Yanan Du, Peipei Chen, Xiaoquan Liu, Haochen Liu
Summary: Alzheimer's disease (AD) is an age-related neurological dysfunction and current treatments have limited clinical benefits. A study showed that DMP1 can induce cell-cycle arrest in neural progenitor cells and may affect cognitive function in Alzheimer-like mice. Silencing DMP1 increased the number of neural progenitor cells and improved cognitive function in Alzheimer-like mice.
Review
Virology
Baldeep Khare, Richard J. Kuhn
Summary: In the past three decades, multiple flaviviruses from different antigenic groups have spread geographically, leading to the co-circulation of multiple viruses within regions. The morphological heterogeneity of flaviviruses affects antibody recognition, virus neutralization, and infection control. Cross-reactivity among flaviviruses may result in either cross-protection or disease enhancement, although the molecular determinants and mechanisms driving these outcomes are still unclear.
Article
Immunology
Shuo Zhu, Mengying Tao, Yunchuan Li, Xugang Wang, Zikai Zhao, Yixin Liu, Qi Li, Qiuyan Li, Yanbo Lu, Youhui Si, Shengbo Cao, Jing Ye
Summary: This study found that infection with Japanese encephalitis virus (JEV) leads to an increase in H3K27me3 modification in microglial cells and mouse brain. Inhibiting H3K27me3 modification significantly reduces pro-inflammatory cytokine production during JEV infection, indicating its crucial role in the neuroinflammatory response. The increased H3K27me3 modification of E3 ubiquitin ligases following JEV infection leads to downregulation of Rnf19a expression and negative regulation of the neuroinflammatory response.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Immunology
Weijia Zhang, Qikai Yin, Huanyu Wang, Guodong Liang
Summary: The Japanese encephalitis virus (JEV) has five genotypes, with genotypes 1 and 3 historically being more active. Genotypes 4 and 5 have remained silent in low-latitude tropical regions. However, in recent years, genotype 5 emerged in mosquitoes from Tibet and South Korea, leading to cases of viral encephalitis. Similarly, genotype 4 emerged in Australia, causing a local outbreak. These new genotypes present challenges for the prevention and control of Japanese encephalitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Oncology
Ming-Min Chang, Han-Yu Weng, Meng-Shao Lai, Li-Wen Wang, Shang-Hsun Yang, Chia-Ching Wu, Chia-Yih Wang, Bu-Miin Huang
Summary: This study found that FGF9 can promote cell proliferation and tumorigenesis in TM3 cells through multiple signaling pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Microbiology
Qi Wang, Shuqing Yang, Ke Yang, Xinran Li, Yu Dai, Yi Zheng, Sanjie Cao, Qigui Yan, Xiaobo Huang, Yiping Wen, Qin Zhao, Senyan Du, Yifei Lang, Shan Zhao, Rui Wu
Summary: This study confirms that porcine CD4 protein is a receptor protein that impacts JEV entry into PK15 cells and subsequent viral replication. The interaction between CD4 and JEV E protein has been identified, and CD4 deficiency affects virus attachment and internalization, as well as viral replication.
VETERINARY MICROBIOLOGY
(2023)
Article
Immunology
Muhammad Naveed Anwar, Chunying Jiang, Di Di, Junjie Zhang, Shuang Guo, Xin Wang, Muddassar Hameed, Abdul Wahaab, Donghua Shao, Zongjie Li, Ke Liu, Beibei Li, Yafeng Qiu, Zhiyong Ma, Jianchao Wei
Summary: VLP-JEVe was constructed by inserting six JEV envelope protein epitopes into PPV VP2 and demonstrated high efficacy in protecting mice and guinea pigs against JEV challenge, inducing neutralizing antibodies and providing 100% protection. The vaccine also induced protective immunity against PPV challenge in guinea pigs, suggesting its potential as a candidate for vaccine development.
Article
Immunology
Chongxiao Xu, Weijia Zhang, Yuefeng Pan, Guowei Wang, Qikai Yin, Shihong Fu, Fan Li, Ying He, Songtao Xu, Zhenhai Wang, Guodong Liang, Kai Nie, Huanyu Wang
Summary: Japanese encephalitis (JE) is a mosquito-borne disease caused by the Japanese encephalitis virus (JEV). The research on JE has been ongoing for nearly 90 years, mainly in Asia. The analysis of English publications shows an increasing number of studies on JE, with a focus on the pathogenic mechanism of the virus, outbreak control, and immunization.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Kumar Saurabh Srivastava, Vandana Jeswani, Nabanita Pal, Babita Bohra, Vaishali Vishwakarma, Atharva Ashish Bapat, Yamini Prashanti Patnaik, Navin Khanna, Rahul Shukla
Summary: Japanese encephalitis virus (JEV) is a potentially severe brain infection that spreads through mosquito bites. Currently, there is no licensed anti-JEV drug available, although there are a few licensed vaccines with limited global use. With over 67,000 cases of JE annually, there is an urgent need to find suitable antiviral drugs for treatment.
Article
Neurosciences
Reshma Bhagat, Prateek Rajpara, Guneet Kaur, Karnika Gupta, Pankaj Seth
Summary: Zika virus affects fetal development by impairing the proliferation and differentiation abilities of neural stem cells. The miR204-5p/WNT2 axis plays a key role in this process.
BRAIN RESEARCH BULLETIN
(2021)
Article
Multidisciplinary Sciences
Panetha Pansri, Phetcharat Phanthong, Nopparat Suthprasertporn, Yindee Kitiyanant, Alisa Tubsuwan, Andras Dinnyes, Julianna Kobolak, Narisorn Kitiyanant
Summary: The study found that BDNF can promote cell proliferation of AD-derived hNPCs, but does not have a promoting effect on neurite outgrowth. The JAK2 inhibitor AG490 partially decreased BDNF-induced cell proliferation.
Article
Biochemistry & Molecular Biology
Tong Zheng, Donna F. Bielinski, Derek R. Fisher, Jianyi Zhang, Barbara Shukitt-Hale
Summary: Blueberry extract has a positive effect on the viability and proliferation rates of adult hippocampal progenitor cells, potentially reversing decreases caused by dopamine, possibly due to its anti-inflammatory, antioxidant, and calcium-buffering properties.
Article
Oncology
Yingji Chen, Ying Ji, Suo Liu, Yicai Liu, Wei Feng, Longyu Jin
Summary: PTBP3 is overexpressed in LUSC tissues and its high expression is significantly correlated with poor prognosis. PTBP3 knockdown results in decreased cell proliferation rate. Bioinformatics analysis reveals that PTBP3 is involved in cell cycle regulation in LUSC.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Sourish Ghosh, Sriparna Mukherjee, Anirban Basu
JOURNAL OF NEUROCHEMISTRY
(2015)
Article
Immunology
Sayantika Mahanti, Arnab Majhi, Kiran Kundu, Anirban Basu, Biswadev Bishayi
JOURNAL OF NEUROIMMUNOLOGY
(2015)
Article
Immunology
Nikhil Sharma, Ruhi Verma, Kanhaiya Lal Kumawat, Anirban Basu, Sunit K. Singh
JOURNAL OF NEUROINFLAMMATION
(2015)
Article
Multidisciplinary Sciences
Sulagna Das, Taofei Yin, Qingfen Yang, Jingqiao Zhang, Yi I. Wu, Ji Yu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Neurosciences
Suhas V. Vasaikar, Sourish Ghosh, Priyam Narain, Anirban Basu, James Gomes
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Article
Multidisciplinary Sciences
Sourish Ghosh, G. Vinodh Kumar, Anirban Basu, Arpan Banerjee
SCIENTIFIC REPORTS
(2015)
Article
Multidisciplinary Sciences
Young J. Yoon, Bin Wu, Adina R. Buxbaum, Sulagna Das, Albert Tsai, Brian P. English, Jonathan B. Grimm, Luke D. Lavis, Robert H. Singer
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Cell Biology
Olena O. Marchenko, Sulagna Das, Ji Yu, Igor L. Novak, Vladimir I. Rodionov, Nadia Efimova, Tatyana Svitkina, Charles W. Wolgemuth, Leslie M. Loew
MOLECULAR BIOLOGY OF THE CELL
(2017)
Article
Multidisciplinary Sciences
Sulagna Das, Hyungseok C. Moon, Robert H. Singer, Hye Yoon Park
Article
Cell Biology
Sriparna Mukherjee, Sourish Ghosh, Arshed Nazmi, Anirban Basu
CELL BIOLOGY INTERNATIONAL
(2015)
Article
Cell Biology
Deepak Kumar Kaushik, Menaka Chanu Thounaojam, Arinjay Mitra, Anirban Basu
INFLAMMATION RESEARCH
(2014)
Article
Neurosciences
Sulagna Das, Robert H. Singer, Young J. Yoon
CURRENT OPINION IN NEUROBIOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Hanae Sato, Sulagna Das, Robert H. Singer, Maria Vera
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89
(2020)
Review
Cell Biology
Sulagna Das, Maria Vera, Valentina Gandin, Robert H. Singer, Evelina Tutucci
Summary: High-resolution imaging technologies have revealed that all living organisms localize mRNAs in subcellular compartments, creating translation hotspots for locally tuning gene expression. Understanding the mechanisms of mRNA transport and local translation is crucial for precise temporal and spatial control of gene expression in response to intracellular and environmental cues. The technological developments in detecting mRNA localization and local translation provide valuable tools for studying gene expression regulation.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Review
Cell Biology
Shivani C. Kharod, Dong-Woo Hwang, Sulagna Das, Young J. Yoon
Summary: Neurons exhibit spatial compartmentalization of gene expression, allowing for site-specific distribution of proteins through local translation. Recent reports have shown coordination between mRNA transport and vesicular and organellar trafficking. High-resolution imaging studies have provided insights into RNA-organelle interactions within subcellular compartments of neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)