Article
Clinical Neurology
Ignacio Alvarez, Monica Diez-Fairen, Miquel Aguilar, Jose Manuel Gonzalez, Montse Ysamat, Juan Pablo Tartari, Maria Carcel, Alvaro Alonso, Britta Brix, Philipp Arendt, Pau Pastor
Summary: By analyzing the accuracy of cerebrospinal fluid markers for Alzheimer disease (AD) and their impact on disease progression, it was found that combination of emerging/core AD markers can improve AD diagnosis, predict the conversion from mild cognitive impairment (MCI) into AD, and forecast a faster progression of dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Alfonso Delgado-Alvarez, Maria Nieves Cabrera-Martin, Maria Valles-Salgado, Cristina Delgado-Alonso, Maria Jose Gil, Maria Diez-Cirarda, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: This study investigated the visuospatial task performance and neural mechanisms in patients with bvFTD and AD. The results showed that patients with AD performed the worst in visuospatial tasks in mild dementia, while patients with bvFTD showed higher correlations between attention and executive functioning and visuospatial performance. The visuospatial deficits in patients with bvFTD were associated with bilateral frontal regions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Luka Rejc, Vanessa Gomez-Vallejo, Ana Joya, Oscar Moreno, Ander Egimendia, Pilar Castellnou, Xabier Rios-Anglada, Unai Cossio, Zurine Baz, Rossana Passannante, Ignacio Tobalina-Larrea, Pedro Ramos-Cabrer, Albert Giralt, Magdalena Sastre, Estibaliz Capetillo-Zarate, Urban Kosak, Damijan Knez, Stanislav Gobec, Mariel Marder, Abraham Martin, Jordi Llop
Summary: The study investigated the potential of butyrylcholinesterase (BChE) as an early biomarker for Alzheimer's disease (AD) by analyzing its abundance in the brains of AD model animals and controls. The results suggested that BChE accumulation in the brain is associated with amyloid beta deposition, indicating its promising role as an early biomarker for AD.
Article
Clinical Neurology
Luka Rejc, Vanessa Gomez-Vallejo, Ana Joya, Gemma Arsequell, Ander Egimendia, Pilar Castellnou, Xabier Rios-Anglada, Unai Cossio, Zurine Baz, Leyre Iglesias, Estibaliz Capetillo-Zarate, Pedro Ramos-Cabrer, Abraham Martin, Jordi Llop
Summary: In this study, the expression of TSPO and x(c)(-) in an Alzheimer's disease mouse model was longitudinally investigated, and the ability of the novel tracers DPA-714 and FSPG to detect these biomarkers was assessed using PET imaging. The results demonstrated a correlation between the uptake of these tracers and amyloid-beta plaque deposition, suggesting their potential as imaging tools for evaluating disease progression.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Natasha Krishnadas, Vincent Dore, Joanne S. Robertson, Larry Ward, Christopher Fowler, Colin L. Masters, Pierrick Bourgeat, Jurgen Fripp, Victor L. Villemagne, Christopher C. Rowe
Summary: Tau accumulation in Alzheimer's disease (AD) occurs slowly and varies according to brain region and disease stage, plateauing at high levels. The rate of accumulation is best measured in the mesial temporal lobe and inferior temporal cortex in preclinical AD, and in large neocortical areas in mild cognitive impairment (MCI) and AD.
Article
Neurosciences
Arianna Sala, Maura Malpetti, Mohsen Farsad, Francesca Lubian, Giuseppe Magnani, Giulia Frasca Polara, Jean-Benoit Epiney, Jubin Abutalebi, Frederic Assal, Valentina Garibotto, Daniela Perani
Summary: Research suggests that lifelong bilingualism has a protective effect on the brain, delaying the onset of dementia. Bilingual individuals with Alzheimer's disease show more severe cerebral hypometabolism but also stronger connectivity in certain cognitive networks compared to monolinguals, particularly in the left hemisphere.
HUMAN BRAIN MAPPING
(2022)
Review
Clinical Neurology
Christina M. Moloney, Val J. Lowe, Melissa E. Murray
Summary: Neurofibrillary tangles, a hallmark of Alzheimer's disease, undergo a dynamic process of maturity that impacts neuron biology and cognitive function. The levels of maturity include pretangles, mature tangles, and ghost tangles, with distinct characteristics observed through tau protein immunostaining and morphologic changes. Post-translational modifications of tau play a significant role in therapeutic targeting strategies for cognitive dysfunction.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Jiahuan Hao, Yan Tang, Xinghua Liu, Ensheng Yao
Summary: The abnormal neural activity in AD patients could be related to the inhibition of PI3K, which affects tau phosphorylation, cerebral glucose metabolism, and synaptic plasticity.
BRAIN RESEARCH BULLETIN
(2021)
Article
Clinical Neurology
Yulong Xu, Zude Chen, Hsiao-Ying Wey, Yingxia Liang, Rudolph E. Tanzi, Can Zhang, Changning Wang
Summary: The study developed a new tracer to visualize SIRT1 in the brains related to aging and AD, displaying the ability to accurately show SIRT1 in AD transgenic mice for the first time. This tracer can provide insights into the neuroanatomical mechanisms of AD and potential biomarkers for aging-related changes in the brain.
ALZHEIMERS & DEMENTIA
(2021)
Article
Ophthalmology
Kallene Summer Moreira Vidal, Diego Decleva, Mirella Telles Salgueiro Barboni, Balazs Vince Nagy, Paulo Augusto Hidalgo de Menezes, Avinash Aher, Artur Martins Coutinho, Paula Squarzoni, Daniele de Paula Faria, Fabio Luis de Souza Duran, Carlos Alberto Buchpiguel, Jan Kremers, Geraldo Busatto Filho, Dora Fix Ventura
Summary: This study evaluated color vision changes and retinal processing in patients with AD and MCI, finding that both groups showed acquired color vision deficiency, which may be related to impaired brain metabolism.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Medicine, General & Internal
Eleni Rebelos, Juha O. Rinne, Pirjo Nuutila, Laura L. Ekblad
Summary: Using [F-18]-FDG-PET to image brain glucose metabolism has been a valuable tool in diagnosing cognitive disorders like Alzheimer's disease, with recent studies revealing connections between obesity, diabetes, and alterations in brain glucose metabolism. Understanding whether changes in brain glucose metabolism are a key determinant in the pathophysiology of metabolic and neurologic disorders is crucial for advancing research in this field.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
HyunChul Youn, Won Seok William Hyung, Junhyung Kim, Eun Seong Lee, Jae Seon Eo, Cheol E. Han, Changsu Han, Seung-Hyun Kim, Hyun-Ghang Jeong
Summary: This study investigated the 1-year changes in neuropsychological test results in older adults with late-life depression and mild cognitive impairment, based on the presence or absence of brain amyloidopathy. The findings showed differences in the extent of change depending on the severity of depressive symptoms and amyloidopathy status. Clinicians should consider exploring neuropathology when assessing older adults with depression and cognitive impairment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Ruben Smith, Francesca Capotosti, Martin Schain, Tomas Ohlsson, Efthymia Vokali, Jerome Molette, Tanja Touilloux, Valerie Hliva, Ioannis K. Dimitrakopoulos, Andreas Puschmann, Jonas Jogi, Per Svenningsson, Mattias Andreasson, Christine Sandiego, David S. Russell, Patricia Miranda-Azpiazu, Christer Halldin, Erik Stomrud, Sara Hall, Klas Bratteby, Elina Tampio L'Estrade, Ruth Luthi-Carter, Andrea Pfeifer, Marie Kosco-Vilbois, Johannes Streffer, Oskar Hansson
Summary: The PET tracer [18F]ACI-12589 can identify alpha-synuclein pathology in patients with multiple-system atrophy, improving diagnosis and allowing for detection of drug target engagement in novel alpha-synuclein targeting therapies.
NATURE COMMUNICATIONS
(2023)
Article
Neuroimaging
Jiaying Lu, Zhengwei Zhang, Ping Wu, Xiaoniu Liang, Huiwei Zhang, Jimin Hong, Christoph Clement, Tzu-Chen Yen, Saineng Ding, Min Wang, Zhenxu Xiao, Axel Rominger, Kuangyu Shi, Yihui Guan, Chuantao Zuo, Qianhua Zhao
Summary: Asymmetric tau deposition in Alzheimer's disease (AD) patients is associated with earlier age at onset, more severe pathological burden, and a steeper cognitive decline, indicating its potential importance in AD heterogeneity.
NEUROIMAGE-CLINICAL
(2023)
Article
Geriatrics & Gerontology
Fumihiko Yasuno, Hiroyuki Minami
Summary: This study used positron emission tomography to investigate the effects of cholinesterase inhibitors on tau pathology in Alzheimer's disease patients. Results showed that participants taking cholinesterase inhibitors had lower annual changes in tau aggregation in specific brain regions, suggesting a potential neuroprotective effect of these drugs in the early stages of disease progression.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)