Journal
JOURNAL OF NEURO-ONCOLOGY
Volume 105, Issue 3, Pages 451-466Publisher
SPRINGER
DOI: 10.1007/s11060-011-0658-6
Keywords
Gliomas; Brain tumors; Viruses; Herpesviruses; Retroviruses; Oncomodulation; Progenitors; Stem cells
Categories
Funding
- NIH [RO1 NS045209, R01 CA134843]
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While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.
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