Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 122, Issue 6, Pages 925-928Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-014-1336-6
Keywords
Brain-derived neurotrophic factor; Electroconvulsive therapy; Treatment-resistant depression; DNA methylation; Promoter
Categories
Funding
- University of Erlangen
- Hannover Medical School
Ask authors/readers for more resources
We examined potential changes in brain-derived neurotrophic factor (BDNF) serum levels and promoter methylation of the BDNF gene in 11 patients with treatment-resistant major depressive disorder during a series of electroconvulsive therapy (ECT). Blood samples were taken before, 1 and 24 h after ECT treatment sessions 1, 4, 7 and 10. Patients remitting under ECT had significantly lower mean promoter methylation rates, especially concerning the exon I promoter, compared to non-remitters (both p < 0.002). These findings may point to a depression subtype in which ECT is particularly beneficial.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available