Article
Biotechnology & Applied Microbiology
Lin Liu, Lu-Guang Jiang, Jin-Hong Luo, Ai-Ai Xia, Li-Qun Chen, Yan He
Summary: This study investigated the phenotypic diversity and genetic basis of root hair length in maize using a diverse association panel. Through GWAS analysis, candidate genes related to cellular signaling, polar growth, disease resistance, and metabolic pathways were identified, shedding light on the genetic mechanisms underlying root hair growth in maize.
Article
Biochemistry & Molecular Biology
Francesca Maselli, Salvatore D'Antona, Mattia Utichi, Matteo Arnaudi, Isabella Castiglioni, Danilo Porro, Elena Papaleo, Paolo Gandellini, Claudia Cava
Summary: This study used a computational approach to investigate the shared genetic factors and specific gene loci of multiple neurodegenerative diseases. The results revealed genetic correlations between certain SNPs and the diseases, and identified differentially expressed miRNAs that may be involved in the regulation of genes associated with selected SNPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Plant Sciences
Jung Min Kim, Jae Il Lyu, Dong-Gun Kim, Nguyen Ngoc Hung, Ji Su Seo, Joon-Woo Ahn, You Jin Lim, Seok Hyun Eom, Bo-Keun Ha, Soon-Jae Kwon
Summary: This study used genome-wide association mapping to identify and validate quantitative trait nucleotides (QTNs) related to isoflavone contents in soybean seeds. Several QTNs related to isoflavone contents were detected, and significant differences in the transcript levels of core genes in the isoflavone biosynthetic pathway were found between the original cultivar and its mutant. These findings are important for breeding soybean lines with high and stable concentrations of isoflavones.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Reproductive Biology
Rongrong Ding, Yibin Qiu, Zhanwei Zhuang, Donglin Ruan, Jie Wu, Shenping Zhou, Jian Ye, Lu Cao, Linjun Hong, Zheng Xu, Enqin Zheng, Zicong Li, Zhenfang Wu, Jie Yang
Summary: This study aimed to investigate the genetic basis of litter traits in pigs, identifying valuable genes and genetic markers for pig breeding. Through a genome-wide association study, 76 significantly related SNPs and 10 potential candidate genes were detected, including 13 pleiotropic SNPs that affected multiple litter traits. Functional enrichment analysis indicated that significant pathways were associated with hormone secretion and embryo and organ development, providing new insights into improving litter quality in pigs.
Article
Plant Sciences
Guanglian Liao, Min Zhong, Zhiqiang Jiang, Junjie Tao, Dongfeng Jia, Xueyan Qu, Chunhui Huang, Qing Liu, Xiaobiao Xu
Summary: The study revealed the complex biological characteristics of kiwifruit flowers and leaves through GWAS, identifying key genes associated with these traits. An analysis of 946,337 SNP markers also uncovered the genetic structure of A. eriantha and drew conclusions from it.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Genetics & Heredity
Yongyi Du, Ning Kong, Jibin Zhang
Summary: A study identified 65 new genes associated with AMD using methods such as random walk and support vector machine, and found 45 genes related to AMD, with an overlap of 37 genes. Further research revealed the genetic pathogenic factors and related mechanisms of AMD.
FRONTIERS IN GENETICS
(2021)
Article
Fisheries
Liyuan Lv, Chenxin Hu, Hongqiang Xu, Jianfen Ren, Biao Wu, Yinghui Dong, Zhihua Lin
Summary: With the development of high-density integrated farming, the razor clam Sinonovacula constricta is facing pressure from environmental factors, especially ammonia nitrogen, which threatens the growth and survival of aquatic animals. To cultivate new strains with ammonia tolerance, the genetic basis underlying ammonia tolerance of S. constricta needs to be comprehensively dissected. In this study, a genome wide association study (GWAS) was performed to identify the single nucleotide polymorphisms (SNPs) and genes associated with ammonia tolerance. The results provide valuable markers for selective breeding of ammonia-tolerant strains in S. constricta.
Article
Marine & Freshwater Biology
Zujing Yang, Fanhua Sun, Huan Liao, Zhengrui Zhang, Zheng Dou, Qiang Xing, Jingjie Hu, Xiaoting Huang, Zhenmin Bao
Summary: The study identified 21 significant single nucleotide polymorphisms associated with the resilience of Patinopecten yessoensis to ocean acidification, involving neural signal transmission, energy metabolism, and redox reaction. These candidate genes were expressed during larval development and in adult tissues, with significant changes in mantle expression under low pH stress. The genetic variations indicate molecular resilience in P. yessoensis populations, potentially enabling adaptation to future acidification stress.
AQUATIC TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chenxue Mao, Juan Chen, Ting Zou, Yuankang Zhou, Junyan Liu, Xi Li, Xiangping Li, Min Li, Pinhua Pan, Wei Zhuo, Yang Gao, Shuo Hu, Desheng Xiao, Lin Wu, Zhan Wang, Heng Xu, Wen Yang, Yingjie Xu, Haihua Xiao, Kazuhiko Hanada, Wei Zhang, Honghao Zhou, Jiye Yin, Zhaoqian Liu
Summary: This study investigated the pharmacogenomic markers associated with platinum-based chemotherapy response in NSCLC patients through genome-wide association studies and validated the findings in independent cohorts. The results identified two genetic variations (rs2280496 and rs189178649) in the ADCY1 gene that were associated with the sensitivity of platinum-based chemotherapy in NSCLC patients.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Genetics & Heredity
Seyed Mehdi Esmaeili-Fard, Mohsen Gholizadeh, Seyed Hasan Hafezian, Rostam Abdollahi-Arpanahi
Summary: In this study, alternative genome-wide association study (GWAS) approaches were used on the genome of Baluchi sheep to identify genes affecting pregnancy outcomes and lamb growth. The results revealed that calcium ion transport during pregnancy and feeding lambs by milk after parturition have the greatest impact on weight gain.
FRONTIERS IN GENETICS
(2021)
Article
Plant Sciences
Nayoung Ro, Mesfin Haile, Onsook Hur, Ho-Cheol Ko, Jung-Yoon Yi, Hee-Jong Woo, Yu-Mi Choi, Juhee Rhee, Yong-Jik Lee, Dong-Am Kim, Jae-Wang Do, Geon Woo Kim, Jin-Kyung Kwon, Byoung-Cheorl Kang
Summary: This study evaluated the resistance of 197 pepper resources to anthracnose and selected six resistant pepper resources. The study also identified single nucleotide polymorphisms (SNPs) associated with disease resistance, including genes coding for protein kinase receptors and other known genes involved in disease resistance.
Article
Microbiology
Hongjiao Liu, Wodan Ling, Xing Hua, Jee-Young Moon, Jessica S. S. Williams-Nguyen, Xiang Zhan, Anna M. M. Plantinga, Ni Zhao, Angela Zhang, Rob Knight, Qibin Qi, Robert D. D. Burk, Robert C. C. Kaplan, Michael C. C. Wu
Summary: This study proposes a novel approach called the covariate-adjusted KRV framework to map genetic variants associated with microbiome beta-diversity. The framework evaluates the association between genetics and microbes by comparing similarity in genetic profiles to similarity in microbiome profiles across individuals. The study identifies an immunity-related gene IL23R and three other novel genes involved in immune functions or autoimmune disorders. Simulation studies show that the covariate-adjusted KRV has a greater power than other microbiome GWAS methods.
Article
Biotechnology & Applied Microbiology
Xiurong Zhao, Changsheng Nie, Jinxin Zhang, Xinghua Li, Tao Zhu, Zi Guan, Yu Chen, Liang Wang, Xue Ze Lv, Weifang Yang, Yaxiong Jia, Zhonghua Ning, Haiying Li, Changqing Qu, Huie Wang, Lujiang Qu
Summary: This study utilized genome-wide association study to identify 148 SNPs associated with egg number traits and 32 candidate genes related to hormone regulation, follicle development, and reproductive system development. The study also highlighted a genomic region on GGA5 as a potential candidate region underlying egg number traits.
Article
Plant Sciences
Arvind Kumar Yadav, Chandan Kumar Singh, Rajwant K. Kalia, Shikha Mittal, Dhammaprakash P. Wankhede, Rajesh K. Kakani, Shraddha Ujjainwal, Aakash, Ankit Saroha, N. S. Nathawat, Reena Rani, Pooja Panchariya, Manoj Choudhary, Kantilal Solanki, K. K. Chaturvedi, Sunil Archak, Kuldeep Singh, Gyanendra Pratap Singh, Amit Kumar Singh
Summary: This study focused on the genetic diversity, population structure, and marker-trait association of moth bean using genotyping by sequencing (GBS) approach. The Northwestern region of India was identified as the center of diversity for moth bean, and 29 genomic regions associated with flowering trait were discovered. These findings are important for further research and breeding programs of moth bean.
Article
Agronomy
Xukai Li, Zhiyong Shi, Jianhua Gao, Xingchun Wang, Kai Guo
Summary: Haplotype blocks reduce genotyping effort and assist in mapping candidate genes. The CandiHap software allows rapid and robust haplotype analysis and candidate identification from sequencing data. It can be used on various operating systems and any species.
MOLECULAR BREEDING
(2023)
Article
Psychology, Clinical
Chiara Fabbri, Julian Mutz, Cathryn M. Lewis, Alessandro Serretti
Summary: This study was the first to comprehensively evaluate the predictors of wellbeing in relation to the history of MDD. The identified variables are important to identify individuals at risk and promote wellbeing.
PSYCHOLOGICAL MEDICINE
(2023)
Editorial Material
Neurosciences
Dekel Taliaz, Alessandro Serretti
Summary: The validity of clinical trials in psychiatry has been under discussion in the past two decades. The commonly used method of randomized controlled trials (RCTs) faces challenges when applied in the psychiatric field due to strict participant criteria and inconsistency in endpoint parameters. This has led to problematic clinical practice in psychiatry.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Psychiatry
Helle Nystrup Lund, Inge Nygaard Pedersen, Agnieszka M. Heymann-Szlachcinska, Maryla Tuszewska, Gustav Bizik, Jens Ivar Larsen, Antonio Drago, Eszter Kulhay, Anelia Larsen, Helle Ostermark Sorensen, Bettina Gronbech, Lars Rye Bertelsen, Jan Brink Valentin, Jan Mainz, Soren Paaske Johnsen
Summary: This study examined the efficacy of music intervention in depression-related insomnia. The results showed that music intervention can significantly improve sleep quality and well-being. However, the effects of music intervention decreased after the intervention was terminated.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Raimondo Maria Pavarin, Chiara Fabbri, Elsa Turino, Silvia Marani, Samantha Sanchini, Diana De Ronchi
Summary: Suicide is a major global health issue, and alcohol use disorders (AUDs) are an important risk factor for suicide attempts. This study utilized electronic health records to identify individuals diagnosed with AUD in the Metropolitan area of Bologna. The results showed a higher rate of suicide attempts in this population, particularly in females, within one year of AUD diagnosis, and among patients with psychiatric comorbidities or concurrent abuse of cannabis or benzodiazepines. Additionally, the risk of suicide attempts was significantly higher in females in 2020 compared to 2019, possibly due to the COVID-19 pandemic.
JOURNAL OF PSYCHOACTIVE DRUGS
(2023)
Article
Pharmacology & Pharmacy
Vincenzo Oliva, Giuseppe Fanelli, Manuel Zamparini, Cristina Zarbo, Matteo Rocchetti, Letizia Casiraghi, Fabrizio Starace, Alessandra Martinelli, Alessandro Serretti, Giovanni de Girolamo, DiAPASon Consortium
Summary: Antipsychotic polypharmacy (APP) is commonly used in patients with schizophrenia spectrum disorders (SSDs) despite recommendations against it. This study found high rates of APP and lower levels of physical activity in both residential and outpatient patients. However, patients on APP showed trends of reduced sedentariness and higher levels of light physical activity compared to those on monopharmacy.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Review
Psychiatry
Kristina Mozuraityte, Agne Stanyte, Naomi A. Fineberg, Alessandro Serretti, Julija Gecaite-Stonciene, Julius Burkauskas
Summary: This study conducted a scoping review of published literature to examine the relationship between mental fatigue and various psychiatric disorders. The findings suggest that mental fatigue is studied in mood disorders, anxiety disorders, obsessive-compulsive disorder, and obsessive-compulsive personality disorder. Cognitive factors such as unhelpful beliefs about sleep and symptom-focussed rumination, as well as personality risk factors, were found to be relevant in predicting mental fatigue symptoms. Further investigation is needed to explore mental fatigue in adult psychiatric samples.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Psychiatry
Fabio Panariello, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Alessandro Serretti, Chiara Fabbri
Summary: This study aimed to identify factors associated with side effects of psychotropic drugs in a real-world setting enriched with treatment-resistant depression (TRD) patients. Results showed that the severity of depressive symptoms was associated with total, psychic, and neurological side effects, while autonomic side effects were higher in patients with somatic comorbidities and lower in patients receiving trazodone. Multivariate analyses revealed that depressive symptom severity was associated with psychic and total side effects, generalized anxiety disorder (GAD) with neurological side effects, and somatic comorbidities remained associated with autonomic side effects. Trazodone was associated with lower side effects and with augmentation treatments. Augmentation therapies showed opposite effects depending on response status, i.e. increased or decreased the risk of side effects in responders and non-responders/resistant patients, respectively.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Laura Mandelli, Yuri Milaneschi, Sarah Hiles, Alessandro Serretti, Brenda W. Penninx
Summary: An unhealthy lifestyle plays a crucial role in the development and progression of chronic disorders, and it may also affect biological systems involved in stress response. Using data from the Netherlands Study of Depression and Anxiety, researchers calculated a global index of unhealthy lifestyle based on five self-reported habits. They found that the index was associated with hyperactivity of the hypothalamus-pituitary-adrenal axis and increased inflammation, indicating that unhealthy habits increase biological stress. The use of drugs also impacted the autonomic nervous system activity.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Paolo Olgiati, Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Jaime Millan-Santiago, Rosalba Vitagliano, Fortunata Mondella, Roberto Mandrioli, Roccaldo Sardella, Rafael Lucena, Tomaz Vovk, Soledad Cardenas, Federico Boaron, Alessandro Serretti, Carmine Petio, Michele Protti, Laura Mercolini
Summary: In this study, a bioanalytical method using volumetric absorptive microsampling (VAMS) was developed and validated for therapeutic drug monitoring (TDM) of psychiatric patients under cariprazine treatment. The VAMS-UHPLC-MS methodology showed satisfactory results and was proven to be a useful alternative to cariprazine plasma analysis in clinical practice.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Psychiatry
Alexander Kautzky, Lucie Bartova, Gernot Fugger, Markus Dold, Daniel Souery, Stuart Montgomery, Joseph Zohar, Julien Mendlewicz, Chiara Fabbri, Alessandro Serretti, Dan Rujescu, Siegfried Kasper
Summary: This study investigates the differences in presentation and treatment outcomes of treatment-resistant depression (TRD) among different age groups. It finds that age has an impact on depressive symptoms and treatment outcomes. In TRD patients, symptom load and hospitalization time increase with age, while treatment responders do not show this trend. Older patients are more likely to have symptoms such as inner tension, reduced appetite, concentration difficulties, and lassitude.
EUROPEAN PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
H. N. Lund, I. N. Pedersen, A. Heymann-Szlachcinska, M. Tuszewska, G. Bizik, J. I. Larsen, A. Drago, E. Kulhay, A. Larsen, H. O. Sorensen, B. Gronbech, L. R. Bertelsen, J. B. Valentin, J. Mainz, S. P. Johnsen, N. Hannibal, R. MacDonald
EUROPEAN PSYCHIATRY
(2023)
