Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 118, Issue 6, Pages 857-864Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-011-0585-x
Keywords
Chlordiazepoxide; NMDA receptor ligands; Anxiety; Elevated plus-maze; Mice
Categories
Funding
- Funds for Statutory Activity of Medical University of Lublin
- Maria Curie-Sklodowska University, Lublin
- Institute of Pharmacology
- Polish Academy of Sciences
- Jagiellonian University Collegium Medicum, Krakow, Poland
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In the present study, we demonstrated that low, ineffective doses of N-methyl-d-aspartic acid (NMDA) receptor antagonists [competitive NMDA antagonist, CGP 37849, at 0.312 mg/kg intraperitoneally (i.p.), antagonist of the glycine(B) sites, L-701,324, at 2 mg/kg i.p., partial agonist of glycine(B) sites, d-cycloserine, at 2.5 mg/kg i.p.] administered jointly with an ineffective dose of the benzodiazepine, chlordiazepoxide (CDP, 2.5 mg/kg i.p.), significantly increased the percentage of time spent in the open arms of the elevated plus-maze (index of anxiolytic effect). Furthermore, CDP-induced anxiolytic-like activity (5 mg/kg i.p.) was antagonized by NMDA (75 mg/kg i.p.) and by an agonist of glycine(B) sites of the NMDA receptor complex, d-serine [100 nmol/mouse intracerebroventricularly (i.c.v.)]. The present study showed a positive interaction between gamma-aminobutyric acid (GABA) and glutamate neurotransmission in the anxiolytic-like activity in the elevated plus-maze test in mice and this activity seems to particularly involve the NMDA receptors.
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