Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 118, Issue 6, Pages 899-903Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-011-0587-8
Keywords
Parkinson's disease; PARK8; Biopterin; Cerebrospinal fluid; Dopamine; Leucine-rich repeat kinase 2
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Funding
- Ministry of Health, Labor and Welfare of Japan
- Research Committee of CNS Degenerative Diseases, the Ministry of Health, Labor and Welfare of Japan
- Japan Society for the Promotion of Science [20009634]
- Grants-in-Aid for Scientific Research [21500305] Funding Source: KAKEN
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PARK8 is the most common form of familial Parkinson's disease (PD). We measured biopterin and monoamine metabolite levels in the cerebrospinal fluids of 7 PARK8 patients (I2020T mutation in leucine-rich repeat kinase 2), 2 asymptomatic mutation carriers, and 21 sporadic PD patients. The biopterin levels in PARK8 patients were significantly higher than those in sporadic PD patients, although the symptoms were comparable in both groups, suggesting that PARK8 patients exhibit parkinsonian symptoms with higher biopterin levels than sporadic PD patients.
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