Article
Nutrition & Dietetics
Can Sun, Ding Ding, Zhouyu Wen, Chengmei Zhang, Juan Kong
Summary: There is a dose-response relationship between plasma zinc (Zn) and risk of Hyperhomocysteinemia (HHcy) in patients in Northeast China, with a threshold level of 83.89 mu mol/L for reducing HHcy risk. Therefore, individuals in this region, especially those with the MTHFR 677TT polymorphism, should pay attention to their plasma Zn and homocysteine levels.
Article
Biochemistry & Molecular Biology
Giovanni Delli Carpini, Luca Giannella, Jacopo Di Giuseppe, Nina Montik, Michele Montanari, Mariasole Fichera, Daniele Crescenzi, Carolina Marzocchini, Maria Liberata Meccariello, Donato Di Biase, Arianna Vignini, Andrea Ciavattini
Summary: This study suggests that the MTHFR C677T homozygous polymorphism may be a risk factor for endometriosis, potentially explaining the association through altered DNA methylation and reduced activity of antioxidant systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Hee Yun Cha, Soo Jin Yang, Sung-Wan Kim
Summary: Inflammation is a risk factor for schizophrenia, and the dietary inflammatory index (DII) is positively associated with schizophrenia, suggesting that patients with schizophrenia tend to have more pro-inflammatory diets.
Article
Medicine, General & Internal
Qiankun Chen, Zhengjiang Wei, Leying Wang, Xizhan Xu, Zhenyu Wei, Panpan Zheng, Kai Cao, Zijun Zhang, Kexin Chen, Qingfeng Liang
Summary: Patients with schizophrenia are more likely to experience asymptomatic dry eye disease, with mild symptoms and obvious signs. The inflammatory cytokines in the tears of schizophrenic patients differed greatly from that of non-schizophrenic patients.
FRONTIERS IN MEDICINE
(2022)
Article
Psychiatry
Xu Zhu, Dachun Chen, Meihong Xiu, Shen Li, Xiang Yang Zhang
Summary: This study compared serum BDNF and glycolipid profiles between patients with deficit schizophrenia (DS) and non-deficit schizophrenia (NDS), and found that BDNF levels were lower in DS patients and triglyceride levels were an independent predictor for DS. Furthermore, serum BDNF levels were negatively associated with the severity of deficit syndrome in schizophrenia patients, and the differences in glycolipid metabolism patterns between DS and NDS patients indicate that deficit syndrome is an independent endophenotype of schizophrenia.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Behnaz Azimi Manavi, Amanda L. Stuart, Julie A. Pasco, Jason M. Hodge, D. Kavindi Weerasinghe, Rasika M. Samarasinghe, Lana J. Williams
Summary: Antipsychotic use is associated with an increased risk of fracture, particularly in men and women. Regular monitoring of bone health is suggested for individuals using antipsychotic medications.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Fawzia A. Saafan, Ayman Z. Elsamanoudy, Dalia Shaalan, Nanees Zeidan, Mohammad A. Gaballah
Summary: This study found that patients with AGA have higher levels of SH, and the C677T polymorphism of MTHFR is associated with an increased risk of CHD. The mutant T allele is correlated with hyperhomocysteinemia and an increased risk of CHD in AGA patients, highlighting the importance of cardiac evaluation and follow-up in this population.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Health Care Sciences & Services
Danis Pertiwi, Muchlis Achsan Udji Sofro, Tri Indah Winarni, Ari Natalia Probandari
Summary: This study aimed to assess the role of the MTHFR C665T gene polymorphism in the risk of macrocytic anemia among HIV-infected individuals receiving zidovudine. The results showed that sex, age, education level, duration of AZT use, and homocysteine levels were predictors of macrocytic anemia, while MTHFR C665T gene polymorphism and MMA levels were not risk factors.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2022)
Article
Pediatrics
Jyotdeep Kour Raina, Rakesh Kumar Panjaliya, Vikas Dogra, Sushil Sharma, Anupriya, Parvinder Kumar
Summary: This study found a significant association between the MTHFR gene's C677T polymorphism and the risk of Congenital Heart Defects (CHD) through case-control association pilot study and meta-analysis. However, no significant association was observed between the MS gene's A2756G polymorphism and CHD risk.
Article
Psychiatry
Mustafa Abdul Karim, Nadeen Al-Baz, Sami Ouanes, Ali Khalil, Ahmed H. Assar, Abdulkarim Alsiddiqi, Zeinab Dabbous, Mahmoud Zirie, Peter Woodruff, Rayaz A. Malik, Peter M. Haddad
Summary: Patients in Qatar with schizophrenia and diabetes receive sub-optimal diabetes care compared to those with diabetes alone.
Article
Psychiatry
Mariko Tsukiji, Tsuyoshi Sasaki, Yusuke Nakata, Kiyomitsu Ota, Tsutomu Aoki, Koichiro Hara, Takashi Mamada, Jun Nakane, Masanobu Kogure, Ryota Seki, Keita Idemoto, Tasuku Hashimoto, Hiraki Koishikawa, Toshihiro Moriyama, Takaaki Suzuki, Nobuhisa Kanahara, Itsuko Ishii, Masaomi Iyo, Tomihisa Niitsu
Summary: The study found that smoking history and low-dose antipsychotic treatment in the past 5 years may lead to discontinuation of clozapine in patients with treatment-resistant schizophrenia in the early phase of introduction. Eosinophilia was identified as a common reason for discontinuation.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Beata R. Godlewska, Amedeo Minichino, Uzay Emir, Ilinca Angelescu, Belinda Lennox, Masa Micunovic, Oliver Howes, Philip J. Cowen
Summary: Abnormalities in glutamate neurotransmission are associated with psychotic symptoms and cognitive dysfunction in schizophrenia. Ultra-high-field MRS provides greater precision in measuring glutamate, particularly in differentiating it from glutamine. Lower concentrations of glutamate and glutamine were found in the anterior cingulate cortex (ACC) of young men with early psychosis, and a strong correlation between ACC glutamate concentration and cognitive performance was observed in these patients. Further studies are needed to replicate these findings and explore the link between ACC glutamate and cognitive function in larger samples.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Computer Science, Interdisciplinary Applications
Bill Qi, Sonia Boscenco, Janani Ramamurthy, Yannis J. Trakadis
Summary: This study evaluates the performance of machine learning in classifying schizophrenia cases and controls based on gene expression microarray data. The results show above-chance performance in classification and suggest that ML analysis of gene expressions can contribute to our understanding of schizophrenia's pathophysiology and aid in identifying novel treatments.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Psychiatry
Fethia Mohammed, Biftu Geda, Tesfaye Assebe Yadeta, Yadeta Dessie
Summary: The study found that genetic risk factors and some modifiable behaviors are associated with schizophrenia in eastern Ethiopia, highlighting the need for special attention to those at risk.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Shen Li, Dachun Chen, Meihong Xiu, Jie Li, Xiang Yang Zhang
Summary: This study revealed that patients with schizophrenia comorbid with type 2 diabetes mellitus have higher serum BDNF levels and better performance in delayed memory, suggesting a potential relationship between BDNF levels and cognitive function in this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
