Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 117, Issue 4, Pages 505-512Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-010-0377-8
Keywords
Brain-derived neurotrophic factor; Eating disorders; Anorexia nervosa; Bulimia nervosa; Psychopathology; EDI; Interoceptive awareness; Maturity fears; Drive for thinness; Body dissatisfaction
Categories
Funding
- Psychiatry Genetics Network [G03/184]
- Ministry of Education and Science
- Fondo de Investigaciones Sanitarias de la Seguridad Social, FIS [PI40632, PI052307, PI081714]
- Department of Health (Generalitat de Catalunya)
- Department of Education and Universities, Research and Information Society [2005SGR00008, 2009SGR 1554]
- Genoma Espana
- Spanish Ministry of Science and Education [SAF2002-00799]
- Danone Institute fellowship
- CIBEROBN
- Ministerio de Ciencia y Tecnologia
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Association studies and rodent models suggest a major role for BDNF (brain-derived neurotrophic factor) in feeding regulation. Altered BDNF blood levels have been associated with eating disorders (ED) and their related psychopathological traits. Since the influence of BDNF on self-reported eating disorder inventory scores (EDI) has not been tested, we investigated the correlation of EDI scales with BDNF plasma levels. BDNF levels were measured by (ELISA), and the EDI questionnaire was administered in a total of 81 ED patients. The relationship between BDNF levels and EDI scores was calculated using a general linear model. After correcting for multiple testing, BDNF plasma levels negatively correlated with the EDI total score (R-2 = 0.26; p = 4.09 x 10(-4)), interoceptive awareness (R-2 = 0.26; p = 1.96 x 10(-4)), and maturity fears (R-2 = 0.13; p = 6.92 x 10(-4)). When subdividing according to the main diagnoses, interoceptive awareness presented significant correlations with BDNF blood levels in both the anorexia nervosa (R-2 = 0.33, p = 0.0026) and bulimia nervosa groups (R-2 = 0.10; p = 0.008). Our data suggest that BDNF levels may influence the severity of the ED by modulating the associated psychopathology, in particular through the impairment of interoceptive awareness.
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