Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 117, Issue 11, Pages 1253-1260Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-010-0468-6
Keywords
Migraine; Serotonin; Tryptophan hydroxylase; Genetic association study
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Funding
- University of Muenster Medical School [IMF MA1 2 06 16]
- Rolf-Dierichs-Fund Muenster
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The serotonergic system plays a major role in the etiology of migraine. The rate-limiting enzyme in serotonin homeostasis and availability is tryptophan hydroxylase (TPH). The TPH2 isoform is responsible for the cerebral serotonin biosynthesis. To investigate the role of genetic variation in TPH2 in the pathogenesis of migraine eight haplotype tagging SNPs covering the whole TPH2 gene where chosen using Haploview and genotyped in 503 migraineurs and 515 healthy controls. Association analysis was performed on a single SNP and haplotype basis using chi (2) and logistic regression analysis. Single SNP analysis revealed a weak association with migraine, which did not remain after correction for multiple testing. Haplotype analyses revealed association of a haplotype with migraine without aura. Stratification by aura and triptan response did not reveal a positive association with the investigated polymorphisms. These results suggest a possible influence of genetic variation in TPH2 in the pathogenesis of migraine.
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