Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 115, Issue 6, Pages 829-830Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-008-0023-x
Keywords
PKA activator; 8-Br-cAMP; FST
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The PKA activator, 8-Br-cAMP, dose-dependently reduced the immobility time in the forced swim test in rats. This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator.
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