Levodopa-induced plasticity: a double-edged sword in Parkinson's disease?

Derangement of Ras-Guanine Nucleotide-Releasing Factor 1 (Ras-GRF1) and Extracellular Signal-Regulated Kinase (ERK) Dependent Striatal Plasticity in L-DOPA-Induced Dyskinesia

(2015) Milica Cerovic et al.   BIOLOGICAL PSYCHIATRY

A network centred on the inferior frontal cortex is critically involved in levodopa-induced dyskinesias

(2014) Antonio Cerasa et al.   BRAIN

Genetic impact on cognition and brain function in newly diagnosed Parkinson’s disease: ICICLE-PD study

(2014) Cristina Nombela et al.   BRAIN

Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease

(2014) Hélène Hall et al.   BRAIN

l-DOPA reverses the impairment of Dentate Gyrus LTD in experimental parkinsonism via β-adrenergic receptors

(2014) Valentina Pendolino et al.   EXPERIMENTAL NEUROLOGY

Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model

(2014) Haruo Nishijima et al.   MOVEMENT DISORDERS

Clinical markers for identifying cholinergic deficits in Parkinson's disease

(2014) Martijn L.T.M. Müller et al.   MOVEMENT DISORDERS

Cognitive deficits in Parkinson's disease: A cognitive neuroscience perspective

(2014) Trevor W. Robbins et al.   MOVEMENT DISORDERS

Direct and indirect pathways of basal ganglia: a critical reappraisal

(2014) Paolo Calabresi et al.   NATURE NEUROSCIENCE

Lack of depotentiation at basal ganglia output neurons in PD patients with levodopa-induced dyskinesia

(2014) I.A. Prescott et al.   NEUROBIOLOGY OF DISEASE

Morphological and electrophysiological changes in intratelencephalic-type pyramidal neurons in the motor cortex of a rat model of levodopa-induced dyskinesia

(2014) Tatsuya Ueno et al.   NEUROBIOLOGY OF DISEASE

Selective loss of bi-directional synaptic plasticity in the direct and indirect striatal output pathways accompanies generation of parkinsonism and l-DOPA induced dyskinesia in mouse models

(2014) Sherri L. Thiele et al.   NEUROBIOLOGY OF DISEASE

Course of psychiatric symptoms and global cognition in early Parkinson disease

(2014) P. de la Riva et al.   NEUROLOGY

Multiple Modes of Impulsivity in Parkinson's Disease

(2014) Cristina Nombela et al.   PLoS One

Entacapone Reduces Cortical Activation in Parkinson's Disease with Wearing-Off: A f-MRI Study

(2014) Nicola Tambasco et al.   PLoS One

Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia

(2014) M. Heiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical time window for dopamine actions on the structural plasticity of dendritic spines

(2014) S. Yagishita et al.   SCIENCE

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia

(2014) Tim Fieblinger et al.   Nature Communications

Cerebellum in Levodopa-Induced Dyskinesias: The Unusual Suspect in the Motor Network

(2014) Asha Kishore et al.   Frontiers in Neurology

Drug-evoked synaptic plasticity: beyond metaplasticity

(2013) Meaghan C Creed et al.   CURRENT OPINION IN NEUROBIOLOGY

Dual effects of l-DOPA on nigral dopaminergic neurons

(2013) Ezia Guatteo et al.   EXPERIMENTAL NEUROLOGY

Aberrant Restoration of Spines and their Synapses in L-DOPA-Induced Dyskinesia: Involvement of Corticostriatal but Not Thalamostriatal Synapses

(2013) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

New Insights into the Specificity and Plasticity of Reward and Aversion Encoding in the Mesolimbic System

(2013) S. F. Volman et al.   JOURNAL OF NEUROSCIENCE

New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease

(2013) Paolo Calabresi et al.   LANCET NEUROLOGY

Dopamine overdose hypothesis: Evidence and clinical implications

(2013) David E. Vaillancourt et al.   MOVEMENT DISORDERS

Dopamine restores reward prediction errors in old age

(2013) Rumana Chowdhury et al.   NATURE NEUROSCIENCE

Immediate-early gene expression in structures outside the basal ganglia is associated to l-DOPA-induced dyskinesia

(2013) Matthieu F. Bastide et al.   NEUROBIOLOGY OF DISEASE

Dopamine and extinction: A convergence of theory with fear and reward circuitry

(2013) Antony D. Abraham et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Levodopa reinstates connectivity from prefrontal to premotor cortex during externally paced movement in Parkinson's disease

(2013) Damian M. Herz et al.   NEUROIMAGE

Molecular mechanisms of homeostatic synaptic downscaling

(2013) Benjamin Siddoway et al.   NEUROPHARMACOLOGY

Acute dopamine boost has a negative effect on plasticity of the primary motor cortex in advanced Parkinson's disease

(2012) A. Kishore et al.   BRAIN

Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson’s disease

(2012) Cinzia Costa et al.   BRAIN

Theta-burst stimulation and striatal plasticity in experimental parkinsonism

(2012) Veronica Ghiglieri et al.   EXPERIMENTAL NEUROLOGY

Rebalance of Striatal NMDA/AMPA Receptor Ratio Underlies the Reduced Emergence of Dyskinesia During D2-Like Dopamine Agonist Treatment in Experimental Parkinson's Disease

(2012) V. Bagetta et al.   JOURNAL OF NEUROSCIENCE

Dopamine Modulates Episodic Memory Persistence in Old Age

(2012) R. Chowdhury et al.   JOURNAL OF NEUROSCIENCE

New synaptic and molecular targets for neuroprotection in Parkinson's disease

(2012) Paolo Calabresi et al.   MOVEMENT DISORDERS

Impulse Control and Related Disorders in Parkinson’s Disease

(2012) Daniel Weintraub et al.   Neurodegenerative Diseases

Cognitive Impairment in Parkinson’s Disease: The Dual Syndrome Hypothesis

(2012) Angie A. Kehagia et al.   Neurodegenerative Diseases

The Spike-Timing Dependence of Plasticity

(2012) Daniel E. Feldman   NEURON

Abnormal bidirectional plasticity-like effects in Parkinson's disease

(2011) Y.-Z. Huang et al.   BRAIN

Early, severe and bilateral loss of LTP and LTD-like plasticity in motor cortex (M1) in de novo Parkinson’s disease

(2011) Asha Kishore et al.   CLINICAL NEUROPHYSIOLOGY

Dopamine-Dependent Long-Term Depression Is Expressed in Striatal Spiny Neurons of Both Direct and Indirect Pathways: Implications for Parkinson's Disease

(2011) V. Bagetta et al.   JOURNAL OF NEUROSCIENCE

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias

(2011) Fabrizio Gardoni et al.   NEUROBIOLOGY OF AGING

Deficits in inhibitory control and conflict resolution on cognitive and motor tasks in Parkinson’s disease

(2011) Ignacio Obeso et al.   EXPERIMENTAL BRAIN RESEARCH

Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia

(2010) Daniella Rylander et al.   ANNALS OF NEUROLOGY

Impulse Control Disorders in Parkinson Disease

(2010) Daniel Weintraub et al.   ARCHIVES OF NEUROLOGY

Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia

(2010) Barbara Picconi et al.   BRAIN

Distinct Levels of Dopamine Denervation Differentially Alter Striatal Synaptic Plasticity and NMDA Receptor Subunit Composition

(2010) V. Paille et al.   JOURNAL OF NEUROSCIENCE

Dosage-dependent non-linear effect ofl-dopa on human motor cortex plasticity

(2010) Katia Monte-Silva et al.   JOURNAL OF PHYSIOLOGY-LONDON

Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap

(2010) Paolo Calabresi et al.   LANCET NEUROLOGY

Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease

(2010) Angie A Kehagia et al.   LANCET NEUROLOGY

Aberrant striatal plasticity is specifically associated with dyskinesia following levodopa treatment

(2010) Pauline Belujon et al.   MOVEMENT DISORDERS

Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum

(2010) David M. Lovinger   NEUROPHARMACOLOGY

The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens

(2010) Scott J. Russo et al.   TRENDS IN NEUROSCIENCES

Neurobiological Mechanisms of Placebo Responses

(2009) Jon-Kar Zubieta et al.   Annals of the New York Academy of Sciences

Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: From experimental models to neurodegenerative diseases

(2009) Paolo Gubellini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Levodopa enhances synaptic plasticity in the substantia nigra pars reticulata of Parkinson's disease patients

(2008) I. A. Prescott et al.   BRAIN

The Endocannabinoid System in Parkinsons Disease

(2008) Massimiliano Di Filippo et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular mechanisms of L-DOPA-induced dyskinesia

(2008) Peter Jenner   NATURE REVIEWS NEUROSCIENCE

Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

(2008) W. Shen et al.   SCIENCE

l-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation

(2007) Barbara Picconi et al.   NEUROBIOLOGY OF DISEASE