Article
Psychology, Multidisciplinary
Thiemo Knaust, Matthias B. D. Siebler, Dagmar Tarnogorski, Philipp Skiberowski, Helge Hoellmer, Christian Moritz, Holger Schulz
Summary: This study compared hippocampal subfield volumes among soldiers with PTSD, MDD, and AdjD using routine clinical data. The results showed no significant volume differences between these stress-related mental disorders.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychiatry
Ifat Israel-Elgali, Hope Pan, Keren Oved, Nir Pillar, Gilad Levy, Boaz Barak, Ana Carneiro, David Gurwitz, Noam Shomron
Summary: Major depressive disorder (MDD) is a common mental disorder that is commonly treated with selective serotonin reuptake inhibitors (SSRIs). However, the mechanism of how SSRIs lead to remission from MDD is still under debate. This study suggests that deficits in myelination and white matter abnormalities may play a role in the delayed remission following SSRI treatment. The researchers found evidence of changes in miRNA expression and related genes, indicating a potential involvement of miRNAs in myelination processes in response to chronic stress and SSRI treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Fabio L. S. Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl, Cynthia H. Y. Fu, Beata R. Godlewska, Ian H. Gotlib, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Geoffrey B. Hall, Ben J. Harrison, Sean N. Hatton, Marco Hermesdorf, Ian B. Hickie, Tiffany C. Ho, Norbert Hosten, Andreas Jansen, Claas Kaehler, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kraemer, Axel Krug, Jim Lagopoulos, Ramona Leenings, Frank P. MacMaster, Glenda MacQueen, Andrew McIntosh, Quinn McLellan, Katie L. McMahon, Sarah E. Medland, Bryon A. Mueller, Benson Mwangi, Evgeny Osipov, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Jonathan Repple, Pedro G. P. Rosa, Matthew D. Sacchet, Philipp G. Saemann, Knut Schnell, Anouk Schrantee, Egle Simulionyte, Jair C. Soares, Jens Sommer, Dan J. Stein, Olaf Steinstraeter, Lachlan T. Strike, Sophia I. Thomopoulos, Marie-Jose van Tol, Ilya M. Veer, Robert R. J. M. Vermeiren, Henrik Walter, Nic J. A. van der Wee, Steven J. A. van der Werff, Heather Whalley, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Henry Voelzke, Tony T. Yang, Vasileios Zannias, Greig I. de Zubicaray, Giovana B. Zunta-Soares, Christoph Abe, Martin Alda, Ole A. Andreassen, Erlend Boen, Caterina M. Bonnin, Erick J. Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany M. Chaim-Avancini, Torbjorn Elvsashagen, Pauline Favre, Sonya F. Foley, Janice M. Fullerton, Jose M. Goikolea, Bartholomeus C. M. Haarman, Tomas Hajek, Chantal Henry, Josselin Houenou, Fleur M. Howells, Martin Ingvar, Rayus Kuplicki, Beny Lafer, Mikael Landen, Rodrigo Machado-Vieira, Ulrik F. Malt, Colm McDonald, Philip B. Mitchell, Leila Nabulsi, Maria Concepcion Garcia Otaduy, Bronwyn J. Overs, Mircea Polosan, Edith Pomarol-Clotet, Joaquim Radua, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Jonathan Savitz, Aart H. Schene, Peter R. Schofield, Mauricio H. Serpa, Kang Sim, Marcio Gerhardt Soeiro-de-Souza, Ashley N. Sutherland, Henk S. Temmingh, Garrett M. Timmons, Anne Uhlmann, Eduard Vieta, Daniel H. Wolf, Marcus V. Zanetti, Neda Jahanshad, Paul M. Thompson, Dick J. Veltman, Brenda W. J. H. Penninx, Andre F. Marquand, James H. Cole, Lianne Schmaal
Summary: Major depressive disorder is associated with increased risk of brain atrophy, aging-related diseases, and mortality. This study found that MDD patients showed a higher brain-predicted age difference compared to controls, but this difference did not seem to be driven by specific clinical characteristics. Subtle patterns of age-related structural brain abnormalities in MDD were observed, highlighting the need for further longitudinal studies to assess the clinical value of these findings.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: SUMOylation plays a significant role in maintaining neuronal function in the development of major depressive disorder (MDD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medical Laboratory Technology
Masoomeh Dadkhah, Mohsen Jafarzadehgharehziaaddin, Soheila Molaei, Morteza Akbari, Negin Gholizadeh, Farzaneh Fathi
Summary: Depressive disorders, characterized by loss of interest in previously enjoyed activities and a depressed mood, are highly heterogeneous psychiatric diseases. Diagnosis and treatment of major depressive disorder (MDD) remain challenging due to significant clinical presentation heterogeneity and lack of applicable biomarkers. Identification of relevant biomarkers would enhance disease classification and personalized treatment strategies. In this review, we discuss the current state of these biomarkers and diagnostic techniques specifically targeting these analytes using state-of-the-art biosensor technology.
CLINICA CHIMICA ACTA
(2023)
Article
Clinical Neurology
Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu, Ross J. Baldessarini
Summary: The study compared patients diagnosed with DSM-5 type II bipolar disorder (BD2) and major depressive disorder (MDD). The results showed significant differences between BD2 and MDD patients in terms of symptoms, morbidity, and treatment, which can contribute to better differentiation and treatment planning for the two disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neuroimaging
Laura Finlayson-Short, Ben J. Harrison, Christopher Davey
Summary: Young people with SAD, MDD, and comorbid SAD-MDD showed deficits in social processing, which were not specifically related to self-other referential processing. Dimensional social anxiety symptoms were correlated with reward system activation.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Tiffany C. Ho, Boris Gutman, Elena Pozzi, Hans J. Grabe, Norbert Hosten, Katharina Wittfeld, Henry Voelzke, Bernhard Baune, Udo Dannlowski, Katharina Foerster, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Tilo Kircher, Axel Krug, Susanne Meinert, Igor Nenadic, Nils Opel, Richard Dinga, Dick J. Veltman, Knut Schnell, Ilya Veer, Henrik Walter, Ian H. Gotlib, Matthew D. Sacchet, Andre Aleman, Nynke A. Groenewold, Dan J. Stein, Meng Li, Martin Walter, Christopher R. K. Ching, Neda Jahanshad, Anjanibhargavi Ragothaman, Dmitry Isaev, Artemis Zavaliangos-Petropulu, Paul M. Thompson, Philipp G. Saemann, Lianne Schmaal
Summary: This study investigated the differences in subcortical shape between patients with major depressive disorder (MDD) and healthy controls. The results showed that both adolescent-onset MDD and recurrent MDD patients had lower thickness and surface area in certain subcortical regions compared to healthy controls.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Keane Lim, Zixu Yang, Nur Amirah Abdul Rashid, Bhing Leet Tan, Justin Dauwels, Jimmy Lee
Summary: The study found that individuals with schizophrenia performed poorer in emotion recognition and theory of mind tasks compared to those with major depressive disorder and healthy controls. There was no statistically significant difference in social cognitive performance between individuals with major depressive disorder and healthy controls.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Joseigla Pinto de Oliveira, Karen Jansen, Taiane de Azevedo Cardoso, Thaise Campos Mondin, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira
Summary: The study aimed to assess the role of childhood trauma in differentiating MDD and BD, as well as to describe the conversion rate from MDD to BD and its predictors. Findings indicated that predictors of conversion to BD included lower education, substance abuse, younger age of onset, and family history, while childhood trauma was not a significant risk factor for conversion.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: Using the DRePS method, common and specific alterations in local functional connectivity patterns were found in patients with BDD and MDD. Patients with both disorders showed decreased DRePS values in multiple brain regions, with MDD patients exhibiting specific decreases in the left caudate. Voxel signals in these regions also contributed to the classification of the two diagnoses.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: This study characterized the common and specific alterations in the dynamic local functional connectivity pattern in patients with bipolar depressive disorder (BDD) and major depressive disorder (MDD) using a newly developed method called dynamic regional phase synchrony (DRePS). The findings provided new insight into the neural mechanism of BDD and MDD patients and could potentially inform the diagnosis and treatment of these disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
J. Lumikukka Socada, John J. Soderholm, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: This study investigated the prevalence, severity, co-occurrence, and overlap of manic symptoms and borderline personality features in unipolar and bipolar major depressive episodes. The results showed that the presence of mixed and borderline features in MDEs is common, with differences in diagnosis-specific features among different subcohorts. The study highlighted the impact of hypomania on perceived BPD features and the correlation between manic symptoms and borderline features.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Rubai Zhou, Jun Chen, Guoqing Zhao, Zuowei Wang, Daihui Peng, Weiping Xia, Ruizhi Mao, Jingjing Xu, Fan Wang, Chen Zhang, Yong Wang, Chengmei Yuan, Yousong Su, Jia Huang, Tao Yang, Chenglei Wang, Lvchun Cui, Jijun Wang, Lena Palaniyappan, Yiru Fang
Summary: The study identified a link between greater GM volume in the right parahippocampal gyrus and higher social function in patients with MDD. Even with improved overall social function over 12 weeks, there were continued differences in social function between high and low-functioning subgroups.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Simone Grimm, Christian Keicher, Christian Paret, Inga Niedtfeld, Christian Beckmann, Maarten Mennes, Stefan Just, Vikas Sharma, Rene Fuertig, Lena Herich, Salome Mack, Claus Thamer, Christian Schultheis, Anne Weigand, Christian Schmahl, Andreas Wunder
Summary: The study investigated the effects of BI 1358894 on the activity of negative stimuli areas in the brains of patients with major depressive disorder (MDD). The results showed that BI 1358894 can attenuate activity in the bilateral amygdala and left anterior insula, and significantly reduce signals in the bilateral amygdala, anterior insula, anterior cingulate cortex, and left dorsolateral prefrontal cortex in response to negative scenes. In comparison, citalopram did not induce significant reductions in BOLD signals.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Manish K. Jha, Cherise Chin Fatt, Abu Minhajuddin, Taryn L. Mayes, Madhukar H. Trivedi
Summary: This study evaluated the association between major depressive disorder (MDD) and accelerated brain aging, and found that brain age can serve as a clinically useful biomarker. The results showed that brain age is associated with the severity of depressive symptoms and antidepressant treatment outcomes.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Neurosciences
Kevin P. Nguyen, Vyom Raval, Abu Minhajuddin, Thomas Carmody, Madhukar H. Trivedi, Richard B. Dewey, Albert A. Montillo
Summary: This study proposes a new data augmentation method called BLENDS, which generates new nonlinear warp fields for synthesizing augmented images from existing 4D fMRI data. The results show that using BLENDS significantly improves the predictive performance of deep learning models in neuroimaging.
BRAIN CONNECTIVITY
(2023)
Article
Clinical Neurology
Manish K. Jha, David J. Williamson, Ghazal Magharehabed, Ibrahim Turkoz, Ella J. Daly, Madhukar H. Trivedi
Summary: This post hoc analysis evaluated the impact of baseline irritability on the clinical outcomes of adults with treatment-resistant depression treated with oral antidepressants and esketamine nasal spray. The results showed that regardless of baseline irritability, the treatment group had better improvement in reducing depression severity and increasing treatment response.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Correction
Psychiatry
Katherine Sanchez, Brittany H. H. Eghaneyan, Michael O. O. Killian, Leopoldo J. J. Cabassa, Madhukar H. H. Trivedi
Article
Clinical Neurology
M. Ishrat Husain, Jane. A. A. Foster, Brittany. L. L. Mason, Sheng Chen, Haoyu Zhao, Wei Wang, Susan Rotzinger, Sakina Rizvi, Keith Ho, Raymond Lam, Glenda MacQueen, Roumen Milev, Benicio. N. N. Frey, Daniel Mueller, Gustavo Turecki, Manish Jha, Madhukar Trivedi, Sidney. H. H. Kennedy
Summary: This study investigates the association between inflammatory tone and response to sequential pharmacotherapies in major depressive disorder. The findings suggest that higher pre-treatment levels of IFN-Gamma and CCL-2 are associated with non-response to escitalopram, and increasing levels of these pro-inflammatory markers may be associated with non-response to adjunctive aripiprazole.
Article
Psychiatry
Ibrahim Turkoz, Craig Nelson, Samuel T. Wilkinson, Stephane Borentain, Matthew Macaluso, Madhukar H. Trivedi, David Williamson, John J. Sheehan, Giacomo Salvadore, Jaskaran Singh, Ella Daly
Summary: This study found that certain baseline characteristics of patients can be used as predictors of treatment response and remission in patients with treatment-resistant depression. Comparing with placebo, the treatment of esketamine nasal spray plus a newly initiated oral antidepressant showed a better reduction of symptoms. In this treatment group, patients who were employed, had no significant anxiety at baseline, and experienced a reduction in CGI-S score at day 8 were more likely to achieve treatment response and remission.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Taryn L. Mayes, Thomas Carmody, A. John Rush, Karabi Nandy, Graham J. Emslie, Beth D. Kennard, Kathryn Forbes, Manish K. Jha, Jennifer L. Hughes, Jessica K. Heerschap, Madhukar H. Trivedi
Summary: This study examined the predictive capabilities of two scales for assessing suicidality in high-risk adolescents. The charts of severely suicidal adolescents in an intensive outpatient program were reviewed, and data from self-report and clinician-completed scales were analyzed. The results showed that both the 9-item Concise Health Risk Tracking Self-Report (CHRT-SR9) and the Columbia Suicide Severity Risk Scale (C-SSRS) were able to predict suicidal events and attempts to some extent. The CHRT-SR9 had a higher sensitivity while the C-SSRS had a higher specificity. These scales provide important parameters for assessing suicidal risk in adolescents.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Kimberlyn Maravet Baig-Ward, Manish Kumar Jha, Madhukar H. Trivedi
PSYCHIATRIC CLINICS OF NORTH AMERICA
(2023)
Article
Psychiatry
Jacqueline R. Anderson, Karabi Nandy, Anne K. Fuller, Taryn L. Mayes, Stevie Spinelli, Suzanne Brann, Felicia Padilla, Jennifer L. Hughes, Madhukar H. Trivedi
Summary: Youth exposure to mental illness in family or friends is a known risk factor for internalizing disorders. This study examines the relationship between mental illness exposure and adolescents' mental health and well-being using self-report measures. The results indicate that there are significant associations between mental illness exposure (through parents, friends, or both) and higher levels of depression and anxiety, as well as lower levels of well-being and quality of life.
PSYCHIATRIC ANNALS
(2023)
Article
Psychiatry
Roger S. Mcintyre, Mohammad Alsuwaidan, Bernhard T. Baune, Michael Berk, Koen Demyttenaere, Joseph F. Goldberg, Philip Gorwood, Roger Ho, Siegfried Kasper, Sidney H. Kennedy, Josefina Ly-Uson, Rodrigo B. Mansur, R. Hamish McAllister-Williams, James W. Murrough, Charles B. Nemeroff, Andrew A. Nierenberg, Joshua D. Rosenblat, Gerard Sanacora, Alan F. Schatzberg, Richard Shelton, Stephen M. Stahl, Madhukar H. Trivedi, Eduard Vieta, Maj Vinberg, Nolan Williams, Allan H. Young, Mario Maj
Summary: Treatment-resistant depression is common and has serious public health implications. The lack of a consensus definition hampers accurate estimates of its prevalence and efforts to identify effective interventions, leading to heterogeneity in treatment decision-making and potentially compromising quality of care.
Article
Psychiatry
Beth D. Kennard, Jennifer L. Hughes, Abu Minhajuddin, Holli Slater, Joseph C. Blader, Taryn L. Mayes, Claire Kirk, Sarah M. Wakefield, Madhukar H. Trivedi
Summary: The Texas Youth Depression and Suicide Research Network (TX-YDSRN) established a research registry in 2020 for youth with depression and/or suicidality in Texas. This report presents the baseline characteristics of the first 1000 participants, focusing on suicidal thoughts and behaviors.
SUICIDE AND LIFE-THREATENING BEHAVIOR
(2023)
Article
Clinical Neurology
Joseph M. Trombello, Alexandra Kulikova, Taryn L. Mayes, Karabi Nandy, Thomas Carmody, Gavin Bart, Edward Nunes, Joy Schmitz, Mariah Kalmin, Steven Shoptaw, Madhukar H. Trivedi
Summary: The study examines the psychometric properties of a scale to measure suicidality among individuals with methamphetamine use disorder. The scale showed strong internal consistency, test-retest reliability, and convergent validity.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Psychology, Clinical
Hoa T. Vo, Alexandra Kulikova, Taryn L. Mayes, Thomas Carmody, Steve Shoptaw, Walter Ling, Joseph M. Trombello, Madhukar H. Trivedi
Summary: This study examined the reliability and validity of the Treatment Effectiveness Assessment (TEA) in individuals with severe methamphetamine use disorder. The results revealed strong correlations among TEA items and with the total score, indicating good internal consistency. The construct validity was acceptable, with the strongest correlation observed between the TEA Health item and the general health status item.
JOURNAL OF SUBSTANCE USE & ADDICTION TREATMENT
(2023)
Article
Psychology, Clinical
Joy M. Schmitz, Angela L. Stotts, Jin H. Yoon, Thomas F. Northrup, Yolanda R. Villarreal, Luba Yammine, Michael F. Weaver, Thomas Carmody, Steven Shoptaw, Madhukar H. Trivedi
Summary: Combining naltrexone and oral bupropion (NTX-BUP) significantly reduces self-reported cigarette smoking while treating methamphetamine (MA) use disorder.
JOURNAL OF SUBSTANCE USE & ADDICTION TREATMENT
(2023)
Article
Clinical Neurology
Charlotte L. Haley, Betsy D. Kennard, David W. Morris, Ira H. Bernstein, Thomas Carmody, Graham J. Emslie, Taryn L. Mayes, A. John Rush
Summary: This study evaluated the psychometric features of the Quick Inventory of Depressive Symptomatology, Adolescent version (QIDS-A17) and the clinician-rated Children's Depression Rating Scale-Revised (CDRS-R). The results demonstrated high total score correlations, internal consistency, and discriminant diagnostic validity for both measures.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
