Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Psychiatry
Mariela Rance, Zhiying Zhao, Brian Zaboski, Stephen A. Kichuk, Emma Romaker, William N. Koller, Christopher Walsh, Cheyenne Harris-Starling, Suzanne Wasylink, Thomas Adams Jr, Patricia Gruner, Christopher Pittenger, Michelle Hampson
Summary: This study aimed to use fMRI neurofeedback as a treatment for OCD. The results showed that neurofeedback targeting the aPFC can reduce symptoms in OCD, but did not significantly affect control over the aPFC. Future studies should optimize the training protocol and clarify the mechanism of action.
PSYCHIATRY RESEARCH
(2023)
Article
Psychology, Clinical
Victor M. Tang, Daniel M. Blumberger, Cory R. Weissman, Julia Dimitrova, Alanah Throop, Shawn M. McClintock, Daphne Voineskos, Tarek K. Rajji, Jonathan Downar, Yuliya Knyahnytska, Benoit H. Mulsant, Paul B. Fitzgerald, Zafiris J. Daskalakis
Summary: The study evaluated the efficacy and cognitive effects of Magnetic Seizure Therapy (MST) in patients with treatment-resistant Obsessive-Compulsive Disorder (OCD). MST did not show significant clinical improvement in a small group of patients with treatment-resistant OCD, but also did not result in serious adverse effects.
DEPRESSION AND ANXIETY
(2021)
Article
Clinical Neurology
Mehran Nematizadeh, Hossein Ghorbanzadeh, Hossein Sanjari Moghaddam, Mohammadreza Shalbafan, Mahsa Boroon, Amir-Abbas Keshavarz-Akhlaghi, Shahin Akhondzadeh
Summary: The main aim of this study was to investigate the additional effects of L-theanine on OCD symptoms in combination with fluvoxamine. The results suggest that L-theanine can be a relatively safe and effective adjuvant therapy for moderate to severe OCD.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Review
Psychiatry
Louise Destree, Mary-Ellen E. Brierley, Lucy Albertella, Laura Jobson, Leonardo F. Fontenelle
Summary: This study conducted a systematic review on the relationships between childhood trauma and obsessive-compulsive symptoms (OCS) severity. The results showed a significant relationship between exposure to childhood trauma and OCS severity in both clinical and non-clinical populations. It was also found that a range of childhood trauma types, rather than a single type, was associated with OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Lena Jelinek, Johanna Schroeder, Lara Buecker, Franziska Miegel, Anna Baumeister, Steffen Moritz, Arne Sibilis, Josephine Schultz
Summary: This study aimed to test whether varying the degree of autonomy in which modules are completed could improve adherence and effects of unguided internet-based cognitive-behavioral therapy (iCBT) for obsessive compulsive disorder (OCD). The results showed that both iCBT programs significantly reduced OCD severity. Although there were no differences in utilization time and number of modules completed, the fixed order of modules was associated with greater improvement in OCD severity and quality of life.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Lilach Rachamim, Hila Mualem-Taylor, Osnat Rachamim, Michael Rotstein, Sharon Zimmerman-Brenner
Summary: This study found that in children and adolescents with tic disorders, both the presence of ADHD and the absence of comorbid ADHD were associated with similar reductions in tic symptoms after internet-delivered, self-help comprehensive behavioral intervention for tics (ICBIT). However, the presence of OCD comorbidity was associated with a lesser response to intervention. Furthermore, the intervention also led to significant reductions in parental reports of inattention, hyperactivity, and impulsivity. Larger studies are needed to further optimize the application of ICBIT in children and teens with both tic disorders and comorbid ADHD and OCD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Psychology, Clinical
Behrang Mahjani, Katharina Bey, Julia Boberg, Christie Burton
Summary: Obsessive-compulsive disorder (OCD) is a heritable, polygenic disorder with contributions from both common and rare genetic variants. Genetics play an important role in the susceptibility to OCD, with discrete OCD symptom dimensions having both shared and unique genetic risks. Genome-wide studies show that OCD shares genetic risk with its comorbid conditions.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Prerika Sharma, Maria C. Rosario, Ygor A. Ferrao, Lucy Albertella, Euripedes C. Miguel, Leonardo F. Fontenelle
Summary: This study investigated the characteristics of patients with comorbid generalized anxiety disorder (GAD) and obsessive-compulsive disorder (OCD), and found that comorbid GAD was associated with an increased number of avoidant behaviors and greater severity of anxiety.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Pei Wang, Wenjie Gu, Jian Gao, Changhong Wang, Jianqun Fang, Maorong Hu, Hui Xiang, Bin Li, Na Liu, Wenxin Tang, Xijin Wang, Yanbin Jia, Yi Li, Yuqi Cheng, Zhen Tang, Helen Blair Simpson, Dan J. Stein, Zhen Wang
Summary: This study in China aims to compare the efficacy of different pharmacotherapy options for patients with obsessive-compulsive disorder who do not respond or achieve remission with first-line treatment. By recruiting a large sample of treatment-naive patients, this study will provide important information for clinical practice guidelines.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Antonio Mantovani, Francesco Neri, Giordano D'Urso, Lucia Mencarelli, Elisa Tatti, Davide Momi, Arianna Menardi, Giulia Sprugnoli, Emiliano Santarnecchi, Simone Rossi
Summary: The study demonstrated that personalized double-daily rTMS treatment for OCD patients is safe, feasible, and effective in improving symptoms with long-lasting benefits. The rsFC analysis revealed a significant reduction in connectivity patterns between SMA and subcortical regions, which are correlated with OCD symptom severity.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Faranak Kadivari, Mahmoud Najafi, Vahid Khosravani
Summary: This study found that childhood maltreatment has both direct and indirect effects on obsessive-compulsive symptoms, with the indirect effect mediated by the behavioral inhibition system. The findings highlight the role of the behavioral inhibition system in linking childhood maltreatment to obsessive-compulsive symptomology.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Katherine Parkin, Shanquan Chen, Marjan Biria, James Plaistow, Helen Beckwith, Isaac Jarratt-Barnham, Nuria Segarra, Yulia Worbe, Naomi A. Fineberg, Rudolf N. Cardinal, Trevor W. Robbins, Emilio Fernandez-Egea
Summary: Obsessive-compulsive symptoms (OCS) commonly occur in patients treated with clozapine and can significantly affect subjective wellbeing. This study found that OCS severity had a negative impact on wellbeing scores, independent of depressive and psychotic symptoms. However, OCS did not impair general functioning. Obsessional thinking and hoarding behavior, rather than compulsions, were specifically associated with decreased wellbeing, possibly due to the nature of the compulsions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: This study revealed a bidirectional longitudinal relationship between eating disorders and obsessive-compulsive disorder, particularly in terms of cognitive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: The study found a bidirectional, longitudinal relationship between symptoms of eating disorders (ED) and obsessive-compulsive disorder (OCD), particularly in terms of cognitive symptoms. However, this longitudinal association was only present at certain time points.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
